Alcohol
Volume 21, Issue 1 , Pages 59-62, May 2000

Development of short-lasting alcohol deprivation effect in Sardinian alcohol-preferring rats

  • Roberta Agabio

      Affiliations

    • Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, I-09124, Italy
    • ,
  • Mauro A.M Carai

      Affiliations

    • Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, I-09124, Italy
    • Neuroscienze S.c.ar.l., Via Palabanda 9, Cagliari, I-09123, Italy
    • ,
  • Carla Lobina

      Affiliations

    • Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, I-09124, Italy
    • Neuroscienze S.c.ar.l., Via Palabanda 9, Cagliari, I-09123, Italy
    • ,
  • Marialaura Pani

      Affiliations

    • Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, I-09124, Italy
    • ,
  • Roberta Reali

      Affiliations

    • Neuroscienze S.c.ar.l., Via Palabanda 9, Cagliari, I-09123, Italy
    • ,
  • Giovanni Vacca

      Affiliations

    • Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, I-09124, Italy
    • Neuroscienze S.c.ar.l., Via Palabanda 9, Cagliari, I-09123, Italy
    • ,
  • Gian Luigi Gessa

      Affiliations

    • Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, I-09124, Italy
    • Neuroscienze S.c.ar.l., Via Palabanda 9, Cagliari, I-09123, Italy
    • CNR Center for Neuropharmacology, University of Cagliari, Via Porcell 4, Cagliari, I-09124, Italy
    • ,
  • Giancarlo Colombo

      Affiliations

    • CNR Center for Neuropharmacology, University of Cagliari, Via Porcell 4, Cagliari, I-09124, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-070-675-8422; fax: +39-070-657-237

Received 27 September 1999; received in revised form 16 December 1999; accepted 27 December 1999.

Abstract 

Alcohol deprivation effect (ADE), defined as a temporary increase in voluntary alcohol intake following a period of alcohol abstinence, was evaluated in selectively bred Sardinian alcohol-preferring (sP) rats. Alcohol was initially offered in free choice with water for 35 consecutive days (predeprivation phase). Subsequently, one group of rats was deprived of alcohol for 1, 3, 7, 15, 30, 90 or 180 consecutive days, while the second group had continuous access to alcohol (deprivation phase). Once alcohol was re-presented, alcohol intake in alcohol-deprived rats was recorded 1 and 24 h after alcohol re-presentation and compared to that monitored in alcohol-nondeprived rats over the same time periods (postdeprivation phase). Alcohol deprivation for 3 to 30 days resulted in a significant increase in voluntary alcohol intake only in the first hour of re-access. These results demonstrate the development of ADE in sP rats. However, the rapid return of alcohol intake to control levels is discussed as evidence in favor of a set-point mechanism capable of regulating alcohol-drinking behavior in sP rats.

Keywords:  Alcohol deprivation effect, Voluntary alcohol intake, Sardinian alcohol-preferring rats, Set-point mechanism for controlling alcohol intake

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PII: S0741-8329(00)00072-0

Alcohol
Volume 21, Issue 1 , Pages 59-62, May 2000

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