Alcohol
Volume 21, Issue 3 , Pages 207-213 , July 2000

Alcohol modulates cytokine secretion and synthesis in human fetus: an in vivo and in vitro study

Received 14 May 1999 ,Revised 24 January 2000 ,Accepted 31 January 2000.

References 

  1. Abel EL, Kruger ML. Hon v. Stroh Brewery: What do we mean by “moderate” and “heavy” drinking?. Alcohol Clin Exp Res. 1995;19:1024–1031
  2. Adams HG, Jordan C. Infections in the alcoholic. Med Clin North Am. 1984;68:179–200
  3. Aggarwal BB, Kohr WJ, Hass PE, Moffat B, Spencer SA, Henzel WJ, et al. Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem. 1985;260:2345–2354
  4. Aggarwal BB, Natarajan K. Tumor necrosis factors: developments during the last decade. Eur Cytokine Netw. 1996;7:93–124
  5. Ahluwalia BS, Westney LS, Rajguru SU. Alcohol inhibits cell mitosis in G2-M phase in cell cycle in a human lymphocytes in vitro study. Alcohol. 1995;12:589–592
  6. Bermudez LE, Young LS. Ethanol augments intracellular survival of Mycobacterium avium complex and impairs macrophage response to cytokines. J Infect Dis. 1991;163:1286–1292
  7. Beutler B, Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature. 1986;320:584–588
  8. Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science. 1986;232:977–980
  9. Bird GL, Sheron N, Goka AK, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med. 1990;112:917–920
  10. Breen EC, Rezai AR, Nakajima K, Beall GN, Mitsuyasu RT, Hirano T, et al. Infection with HIV is associated with elevated IL-6 levels and production. J Immunol. 1990;144:480–484
  11. Cohen MC, Cohen S. Cytokine function: a study in biologic diversity. Am J Clin Pathol. 1996;105:589–598
  12. Cunningham FG, Macdonald PC, Gant NF, Leveno KJ, Gilstrap LC. Williams Obstetrics Normal Labor and Delivery Puerperium. Stanford, CTA: Appleton and Lange Press; 1993;
  13. Danenberg HD, Alpert G, Lustig S, Ben-Nathan D. Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production. Antimicrob Agents Chemother. 1992;36:2275–2279
  14. Deaciuc IV. Alcohol and cytokine networks. Alcohol. 1997;14:421–430
  15. Deaciuc IV, Alappat MJ, D'Souza NB. Effect of acute and chronic alcohol administration to rats on the expression of interleukin-6 cell-surface receptors of hepatic parenchymal and nonparenchymal cells. Alcohol Clin Exp Res. 1994;18:1207–1214
  16. Deaciuc IV, D'Souza NB, Spitzer JJ. Tumor necrosis factor-alpha cell-surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats. Alcohol Clin Exp Res. 1995;19:332–338
  17. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem. 1990;192:245–261
  18. Deviere J, Content J, Denys C, Vandenbussche P, Schandene L, Wybran J, et al. High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. Clin Exp Immunol. 1989;77:221–225
  19. D'Souza NB, Nelson S, Summer WR, Deaciuc IV. Expression of tumor necrosis factor-alpha and interleukin-6 cell-surface receptors of the alveolar macrophage in alcohol-treated rats. Alcohol Clin Exp Res. 1994;18:1430–1435
  20. Gravett MG, Haluska GJ, Cook MJ, Novy MJ. Fetal and maternal endocrine responses to experimental intrauterine infection in rhesus monkeys. Am J Obstet Gynecol. 1996;174:1725–1733
  21. Grossman CJ, Mendenhall CL, Roselle GA. Alcohol and immune regulation. I. In vivo effects of ethanol on concanavalin A sensitive thymic lymphocyte function. Int J Immunopharmacoi. 1988;10:187–195
  22. Grossman CJ, Roselle G, Nienaber M. The effects of alcohol on the cellular immune function in animals. In:  Watson RR editors. Alcohol, Drugs of Abuse and Immune Functions. New York: CRC Press; 1995;p. 17–26
  23. Hill DB, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. J Lab Clin Med. 1992;119:547–552
  24. Jacobson JL, Jacobson SW, Sokol RJ, Martier SS, Ager JW, Kaplan-Estrin MG. Teratogenic effects of alcohol on infant development. Alcohol Clin Exp Res. 1993;17:174–183
  25. Jerrells TR. Effects of ethanol on the immune system. In: Alcoholism: A Molecular Perspective. 206:New York: Plenum Press; 1991;p. 325–330NY NATO ASI series
  26. Jerrells TR, Smith W, Eckardt MJ. Murine model of ethanol-induced immunosuppression. Alcohol Clin Exp Res. 1990;14:546–550
  27. Kern JA, Lamb RJ, Reed JC, Daniel RP, Nowell PC. Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms. J Clin Invest. 1988;81:237–244
  28. Kunkel SL, Wiggins RC, Chensue SW, Larrick J. Regulation of macrophage tumor necrosis factor production by prostaglandin E2. Biochim Biophys Res Commun. 1986;137:404–410
  29. Lee W, Oppenheim JJ, Matsushima K. Analysis of the suppression of IL-1 alpha and IL-1 beta production in human peripheral blood mononuclear adherent cells by a glucocorticoid hormone. J Immunol. 1988;140:1895–1902
  30. Lundy J, Raaf JH, Deakins S, Wanebo HJ, Jacobs DA, Lee T, et al. The acute and chronic effects of alcohol on the human immune system. Surg Gynecol Ob. 1975;141:212–218
  31. Martinez F, Abril ER, Earnest DL, Watson RR. Ethanol and cytokine secretion. Alcohol. 1992;9:455–458
  32. Matsuzaki N, Taniguchi T, Shimoya K, Neki R, Okada T, Saji F, et al. Placental interleukin-6 production is enhanced in intrauterine infection but not in labor. Am J Obstet Gynecol. 1993;168:94–97
  33. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349–351
  34. Miles SA, Rezai AR, Salazar-Gonzalez JF, Vander Meyden M, Stevens RH, Logan DM, et al  AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc Natl Acad Sci USA. 1990;87:4068–4072
  35. Mukherjee AB, Hodgen GD. Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys. Science. 1982;218:700–702
  36. Mutchnick MG, Lee HH. Impaired lymphocyte proliferative response to mitogen in alcoholic patients. Absence of a relation to liver disease activity. Alcohol Clin Exp Res. 1988;12:155–158
  37. Nair MP, Schwartz SA, Kronfol ZA, Hill EM, Sweet AM, Greden JF. Suppression of tumor necrosis factor production by alcohol in lipopolysaccharide-stimulated culture. Alcohol Clin Exp Res. 1994;18:602–607
  38. Nelson S, Bagby GJ, Bainton BG, Summer WR. The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. J Infect Dis. 1989;160:422–429
  39. Rajkovic IA, Yousif-Kadaru AG, Wyke RJ, William SR. Polymorphonuclear leucocyte locomotion and aggregation in patients with alcoholic liver disease. Clin Exp Immunol. 1984;58:654–662
  40. Rodriguez FD, Simonsson P, Alling C. A method for maintaining constant ethanol concentrations in cell culture media. Alcohol Alcohol. 1992;27:309–313
  41. Rubin E, Rottenberg H. Ethanol-induced injury and adaptation in biological membranes. Fed Proc. 1982;41:2465–2471
  42. Seelig LL, Steven WM, Stewart GL. Effects of maternal ethanol consumption on the subsequent development of immunity to trichinella spiralis in rat neonates. Alcohol Clin Exp Res. 1996;20:514–522
  43. Seventh Special Report to U.S. Congress . Effects on the immune system. In: Alcohol and Health. U.S. Department of Health and Human Services; 1990;p. 120–122
  44. Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol. 1985;135:2069–2073
  45. Sheron N, Bird G, Koskinas J, Portmann B, Ceska M, Lindley I, et al. Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis and tissue levels correlates with neutrophil infiltration. Hepatology. 1993;18:41–46
  46. Singh B, Merchant P, Walker CR, Kryworuchko M, Diaz-Mitoma F. Interleukin-6 expression in cord blood of patients with clinical chorioamnionitis. Pediatr Res. 1996;39:976–979
  47. Spinozzi F, Bertotto A, Rondoni F, Gerli R, Scalise F, Grignani F. T-lymphocyte activation pathways in alcoholic liver disease. Immunology. 1991;73:140–146
  48. Straus B, Berenyi MR, Huang JM, Straus E. Delayed hypersensitivity in alcoholic cirrhosis. Am J Dig Dis. 1971;16:509–516
  49. Szabo G, Kodys K, Miller-Graziano CL. Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. II. Downregulation by IL-4. J Clin Immunol. 1991;11:336–344
  50. Szabo G, Mandrekar P, Catalano D. Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha and IL-6 production by acute ethanol treatment. J Leukoc Biol. 1995;58:342–350
  51. Szabo G, Verma B, Catalano D. Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production. J Leukoc Biol. 1993;54:534–544
  52. Takayama TK, Miller C, Szabo G. Elevated tumor necrosis factor alpha production concomitant to elevated prostaglandin E2 production by trauma patients' monocytes. Arch Surg. 1990;125:29–35
  53. Van Voorhis WC, Barrett LK, Sweeney YT, Kuo CC, Patton DL. Analysis of lymphocyte phenotype and cytokine activity in the inflammatory infiltrates of the upper genital tract of female macaques infected with chlamydia trachomati. J Infect Dis. 1996;174:647–650
  54. Verma BK, Fogarasi M, Szabo G. Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes. J Clin Immunol. 1993;13:8–22
  55. Virmani M, Ahluwalia B. Biphasic protein kinase C translocation in PC12 cells in response to short-term and long-term ethanol exposure. Alcohol Alcohol. 1992;27:393–401
  56. Watzl B, Watson RR. Alcohol and cytokines secretion. In:  Yirmiya R,  Taylor AN editor. Alcohol, Immunology, and Cancer. Boca Raton: Boca Raton CRS Press; 1992;p. 88–97

PII: S0741-8329(00)00076-8

Alcohol
Volume 21, Issue 3 , Pages 207-213 , July 2000