Alcohol
Volume 21, Issue 1 , Pages 73-85 , May 2000

Effects of 5-HT3 receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats

  • Zachary A Rodd-Henricks

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    • Corresponding Author InformationCorresponding author. Tel.: +317-278-3003; fax: +317-274-1365
    • ,
  • David L McKinzie

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    • ,
  • Victoria E Edmundson

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    • ,
  • Constance L Dagon

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    • ,
  • James M Murphy

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    • Department of Psychology, Purdue School of Science, Indiana University–Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    • ,
  • William J McBride

      Affiliations

    • Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    • ,
  • Lawrence Lumeng

      Affiliations

    • Departments of Medicine and Biochemistry, VA Medical Center, Indianapolis, IN 46202, USA
    • ,
  • Ting-Kai Li

      Affiliations

    • Departments of Medicine and Biochemistry, VA Medical Center, Indianapolis, IN 46202, USA

Received 15 November 1999 ,Revised 7 February 2000 ,Accepted 9 February 2000.

References 

  1. Beardsley PM, Lopez OT, Gulikson G, Flynn D. Serotonin 5-HT3 antagonist fail to affect ethanol self-administration of rats. Alcohol. 1994;11:389–395
  2. Campbell AD, Kohl RR, McBride WJ. Serotonin-3 receptor and ethanol-stimulated somatodendritic dopamine release. Alcohol. 1996;13:569–574
  3. Campbell AD, McBride WJ. Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens. Pharmacol Biochem Behav. 1995;51:835–842
  4. Carboni E, Acquas E, Fran R, DiChiara G. Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release. Eur J Pharmacol. 1989;164:515–519
  5. Cicero TJ, Snider SR, Perez VJ, Swanson LW. Physical dependence on and tolerance to alcohol in the rat. Physiol Behav. 1971;6:191–198
  6. Fadda F, Garau B, Marchei F, Colombo G, Gessa GL. MDL 72222, a selective 5-HT3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats. Alcohol Alcohol. 1991;26:107–110
  7. Fozard JR. MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxy-tryptamine receptors. Naunyn-Schmeideberg's Arch Pharmacol. 1984;326:36–44
  8. Gebauer A, Merger M, Kilbinger H. Modulation of 5HT3 and 5HT4 receptors of the release of 5-hydroxytryptamine from the guinea pig small intestine. Naunyn-Schmeideberg's Arch Pharmacol. 1993;347:137–140
  9. Grant KA. The role of 5-HT3 receptors in drug dependence. Drug Alcohol Depend. 1995;38:155–171
  10. Grant KA, Barrett JE. Blockade of the discriminative stimulus effects of ethanol with 5-HT3 receptor antagonists. Psychopharmacology. 1991;104:451–456
  11. Heyser CJ, Schulteis G, Koob GF. Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res. 1997;21:784–791
  12. Klein RL, Sanna E, McQuilkin SJ, Whiting PJ, Harris RA. Effects of 5HT3 receptor antagonists on binding and function of mouse and human GABAA receptors. Eur J Pharmacol. 1994;268:237–246
  13. Knapp DJ, Pohorecky LA. Zacopride, a 5-HT3 receptor antagonist, reduces voluntary ethanol consumption in rats. Pharmacol Biochem Behav. 1992;41:847–850
  14. Kostowski W, Dyr W, Krzascik P. The abilities of the 5-HT3 receptor antagonist ICS 205-930 to inhibit alcohol preference and withdrawal seizures in rats. Alcohol. 1993;10:369–373
  15. Koulu M, Lappalainen J, Hietala J, Sjoholm B. Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding. Psychopharmacology. 1990;101:168–171
  16. Meert TF. Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of preferences. Alcohol Alcohol. 1993;28:157–170
  17. McBride WJ, Li T-K. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol. 1998;12:339–369
  18. McKinzie DL, Eha R, Cox R, Stewart RB, Dyr W, Murphy JM, et al. Serotonin-3 receptor antagonism of alcohol intake: effects of drinking conditions. Alcohol. 1998;15:291–298
  19. McKinzie DL, Eha R, McBride WJ, Murphy JM, Lumeng L, Li T-K. Evidence for neuroadaptive changes that occur during abstinence and promote alcohol relapse. Alcohol Clin Exp Res. 1996;20:15A;(Suppl.)
  20. McKinzie DL, Eha R, Murphy JM, McBride WJ, Lumeng L, Li T-K. Effects of taste aversion training on the acquisition of alcohol drinking in adolescent P and HAD rat lines. Alcohol Clin Exp Res. 1996;20:682–687
  21. McKinzie DL, Nowak KL, Yorger L, McBride WJ, Murphy JM, Lumeng L, et al. The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions. Alcohol Clin Exp Res. 1998;22:1170–1176
  22. Rodd-Henricks ZA, McKinzie DL, Shaikh SR, Murphy JM, McBride WJ, Lumeng L, et al. The alcohol deprivation effect is prolonged in the alcohol preferring (P) rat following repeated deprivations. Alcohol Clin Exp Res. 2000;24:8–16
  23. Sellers EM, Toneatto T, Romach MK, Somer GR, Sobell LC, Sobell MB. Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence. Alcohol Clin Exp Res. 1994;18:879–885
  24. Sinclair JD, Li T-K. Long and short alcohol deprivation: effects on AA and P alcohol-preferring rats. Alcohol. 1989;6:505–509
  25. Sinclair JD, Senter RJ. Increased preference for ethanol in rats following deprivation. Psychon Sci. 1967;8:11–12
  26. Spanagel R, Zieglgansberger W. Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci. 1997;18:54–59
  27. Svensson L, Fahlke C, Hard E, Engel JA. Involvement of the serotonergic system in ethanol intake in the rat. Alcohol. 1993;10:219–224
  28. Tomkins DM, Le AD, Sellers EM. Effects of the 5HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure. Psychopharmacology. 1995;117:479–485
  29. Wozniak KM, Pert A, Mele A, Linnoila M. Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study. Brain Res. 1991;540:31–40
  30. Yoshimoto K, McBride WJ, Lumeng L, Li T-K. Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol. 1992;9:17–21

PII: S0741-8329(00)00083-5

Alcohol
Volume 21, Issue 1 , Pages 73-85 , May 2000

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