Alcohol
Volume 21, Issue 1 , Pages 87-95 , May 2000

Mechanisms of suppression of poly I:C-induced activation of NK cells by ethanol

  • Stephanie D Collier

      Affiliations

    • Current address: USDA Poultry Lab, USDA-REE-ARS-MSA-PR, 810 Hwy 12 West, Mississippi State, MS 39762, USA.
    • ,
  • Stephen B Pruett

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: 318-675-4386; fax: 318-675-5889

Received 10 January 2000 ,Revised 28 February 2000 ,Accepted 6 March 2000.

References 

  1. Ben-Eliyahu S, Page GG, Yirmiya R, Taylor AN. Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis. Nat Med. 1996;4:457–460
  2. Black PL, McKinnon KM, Wooden SL, Ussery MA. Antiviral activity of biological response modifiers in a murine model of AIDS. Requirement for augmentation of natural killer cell activity and synergy with oral AZT. Int J Immunopharmacol. 1996;18:633–650
  3. Brenan M, Zinkernagel RM. Influence of one virus infection on a second concurrent primary in vivo antiviral T-cell response. Infect Immun. 1983;41:470–475
  4. Bryant J, Day R, Whiteside TL, Herberman RB. Calculation of lytic units for the expression of cell-mediated cytotoxicity. J Immunol Methods. 1992;146:91–103
  5. Carson E, Pruett SB. Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol: Clin Exp Res. 1996;20:132–138
  6. Chadha KC, Whitney RB, Cummings MK, Norman M, Windle M, Stadler I. Evaluation of interferon system among chronic alcoholics. Prog Clin Biol Res. 1990;325:123–133
  7. Collier , et al.  EtOH suppresses NK cell activation by poly I:C in female B6C3F1 mice: role of endogenous corticosterone. Alcohol: Clin Exp Res. 2000;in press
  8. Cousens LP, Orange JS, Su HC, Biron CA. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc Natl Acad Sci USA. 1997;94:634–639
  9. DeBlaker-Hohe DF, Yamauchi A, Yu C-R, Horvath-Arcidiancono JA, Bloom ET. IL-12 synergizes with IL-2 to induce lymphokine-activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells. Cell Immunol. 1995;165:33–43
  10. Djeu JY, Heinbaugh JA, Holden HT, Herberman RB. Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J Immunol. 1979;122:175–181
  11. Djeu JY, Heinbaugh JA, Vieira WD, Holden HT, Herberman RB. The effect of immunopharmacological agents on mouse natural cell-mediated cytotoxicity and on its augmentation by poly I:C. Immunopharmacology. 1979;1:231–244
  12. Dunn PL, North RJ. Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Infect Immun. 1991;59:2892–2900
  13. Fujisawa J-I, Kawade Y. Properties of nonglycosylated and glycosidase-treated mouse L cell interferon species. Virology. 1981;112:480–487
  14. Gallucci RM, Meadows GG. Ethanol consumption reduces the cytolytic activity of lymphokine-activated killer cells. Alcohol: Clin Exp Res. 1995;19(2):402–409
  15. Gardiner CM, Reen DJ. Differential cytokine regulation of natural killer cell-mediated necrotic and apoptotic cytotoxicity. Immunology. 1998;93(4):511–517
  16. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 1994;369:31–37
  17. Makrigiannis AP, Hoskin DW. Inhibition of CTL induction by rapamycin. J Immunol. 1997;159:4700–4707
  18. Manetti R, Annunziato F, Tomasevic L, Glanno V, Parronchi P, Romagnani S, et al. Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12. Eur J Immunol. 1995;25:2656–2660
  19. Oehler JR, Herberman RB. Natural cell-mediated cytotoxicity in rats: III. Effects of immunopharmacologic treatments on natural reactivity and on reactivity augmented by polyinosinic–polycytidylic acid. Int J Cancer. 1978;21(2):221–229
  20. Ohnishi K, Matsuo S, Matsutani K, Itahashi M, Kakihara K, Suzuki K, et al. Interferon therapy for chronic hepatitis C in habitual drinkers: comparison with chronic hepatitis C in infrequent drinkers. Am J Gastroenterol. 1996;91:1374–1379
  21. Pruett SB, Collier SD, Wu W-J. Ethanol-induced activation of the hypothalamic-pituitary-adrenal axis in a mouse model for binge drinking: role of Ro15-4513-sensitive gamma aminobutyric acid receptors, tolerance, and relevance to humans. Life Sci. 1998;63:1137–1146
  22. Rousseau V, Cremer I, Lauret E, Riviere I, Aguet M, De Maeyer E. Antiviral activity of autocrine interferon-beta requires the presence of a functional interferon type I receptor. J Interferon Cytokine Res. 1995;15:785–789
  23. Salazar AM, Levy HB, Ondra S, Kende M, Scherokman B, Brown D, et al. Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic–polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery. 1996;38:1103–1104
  24. Salazar-Mather TP, Ishikawa R, Biron CA. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. J Immunol. 1996;157:3054–3064
  25. Sayers TJ, Mason LH, Pilaro A, Wiltrout TA, Komschilies K, Munger WL, et al. Substrate-specific proteases (BLT-esterase) are localized predominantly in the natural killer cells of unprimed mice. J Leukocyte Biol. 1993;53:454–461
  26. Selgrade MK, Daniels MJ, Dean JH. Interpreting immunotoxicity testing in terms of enhanced risk of disease: correlation between suppression of natural killer cell activity in mice and susceptibility to cytomegalovirus. J Toxicol Environ Health. 1992;37:123–137
  27. Senik A, Gresser I, Maury C, Gidlund M, Orn A, Wigzell H. Enhancement by interferon of natural killer cell activity in mice. Cell Immunol. 1979;44(1):186–200
  28. Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc Natl Acad Sci USA. 1995;92:5679–5683
  29. Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ. How do cytotoxic lymphocytes kill their targets?. Curr Opin Immunol. 1998;10(5):581–587
  30. Simon MM, Hausmann M, Tran T, Ebnet K, Tschopp J, ThaHla R, et al. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A×B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J Exp Med. 1997;186(10):1781–1786
  31. Sipp TL, Blank SE, Lee EG, Meadows GG. Plasma corticosterone response to chronic ethanol consumption and exercise stress. Proc Soc Exp Biol Med. 1993;204:184–190
  32. Smialowicz RJ, Luebke RW, Rogers RR, Riddle MM, Rowe DG. Manganese chloride enhances natural cell-mediated immune effector cell function: effects on macrophages. Immunopharmacology. 1985;9:1–11
  33. Smialowicz RJ, Rogers RR, Riddle MM, Rowe DG, Luebke RW. In vitro augmentation of natural killer cell activity by manganese chloride. J Toxicol Environ Health. 1986;19:243–254
  34. Snow, R.W. (1996). Characteristics of convicted drinking drivers who attended the Mississippi Alcohol Safety Education Program, 1992–1994: a statistical summary. Report No. 96-3. Social Science Research Center, Mississippi State University.
  35. Spaner D, Raju K, Radvanyi L, Lin Y, Miller RG. A role for perforin in activation-induced cell death. J Immunol. 1998;160:2644–2655
  36. Spitzer JH, Meadows GG. Modulation of perforin, granzyme A, and granzyme B in murine natural killer (NK), IL2 stimulated NK, and lymphokine-activated killer cells by alcohol consumption. Cell Immunol. 1999;194:205–212
  37. Thompson KA, Strayer DR, Salvato PD, Thompson CE, Klimas N, Molavi A, et al. Results of a double-blind placebo-controlled study of the double stranded RNA drug poly I:poly C12U in treatment of HIV infection. Eur J Clin Microbiol Infect Dis. 1996;15:580–587
  38. Trapani JA, Browne KA, Smyth MJ, Jans DA. Localization of granzyme B in the nucleus. J Biol Chem. 1996;271:4127–4133
  39. Whiteside TL, Herberman RB. The role of natural killer cells in immune surveillance of cancer. Curr Opin Immunol. 1995;7:704–710
  40. Wu W-J, Pruett SB. Suppression of splenic natural killer cell activity in a mouse model for binge drinking: I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased NK cell activity. J Pharmacol Exp Ther. 1996;278:1325–1330
  41. Wu W-J, Pruett SB. Suppression of splenic natural killer cell activity in a mouse model for binge drinking: II. Role of the neuroendocrine system. J Pharmacol Exp Ther. 1996;278:1331–1339
  42. Wu W-J, Pruett SB. Involvement of catecholamines and glucocorticoids in ethanol-induced suppression of splenic natural killer cell activity in a mouse model for binge drinking. Alcohol: Clin Exp Res. 1997;21:1030–1036
  43. Wu W-J, Pruett SB. Ethanol decreases host resistance to pulmonary metastases in a mouse model: role of NK cells and the ethanol-induced stress response. Int J Cancer. 1999;in press
  44. Wu W-J, Wolcott RM, Pruett SB. Ethanol decreases the number and activity of splenic natural killer cells in a mouse model for binge drinking. J Pharmacol Exp Ther. 1994;271:722–729
  45. Young JD-E, Hengartner H, Podack ER, Cohn ZA. Purification of a cytolytic pore forming protein from granules of cloned lymphocytes with natural killer activity. Cell. 1986;44:849–859

PII: S0741-8329(00)00087-2

Alcohol
Volume 21, Issue 1 , Pages 87-95 , May 2000

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