Alcohol
Volume 21, Issue 3 , Pages 231-237 , July 2000

Cardiovascular responses to clonidine in alcohol withdrawal: are they related to psychopathology and mental well-being?

  • Claudia Fahlke

      Affiliations

    • Department of Psychology, Göteborg University, P.O. Box 500, SE-405 30, Goteborg, Sweden
  • ,
  • Ulf Berggren

      Affiliations

    • Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgren University Hospital/Mölndal, Goteborg University, SE-431 80, Molndal, Sweden
  • ,
  • Jan Balldin

      Affiliations

    • Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgren University Hospital/Mölndal, Goteborg University, SE-431 80, Molndal, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46-31-343-23-31; fax: +46-31-343-23-48

Received 31 May 1999 ,Revised 8 March 2000 ,Accepted 20 March 2000.

References 

  1. Balldin J, Berggren U, Engel J, Lindstedt G, Sundkler A, Wålinder J. Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal. Biol Psychiatry. 1992;31:712–719
  2. Balldin J, Berggren U, Eriksson E, Lindstedt G, Sundkler A. Guanfacine as an alpha-2-agonist inducer of growth hormone secretion-a comparison with clonidine. Psychoneuroendocrinology. 1993;18:45–55
  3. Berggren U, Fahlke C, Norrby A, Zachrisson O, Balldin J. Subsensitive alpha-2-adrenoceptor function in male alcohol-dependent individuals during six months of abstinence. Drug Alcohol Depend. 1999;57:255–260
  4. Bokström K, Balldin J. A rating scale for assessment of alcohol withdrawal psychopathology (AWIP). Alcohol Clin Exp Res. 1992;16:241–249
  5. Bokström K, Balldin J, Långström G. Alcohol withdrawal and mood. Acta Psychiatr Scand. 1989;80:505–513
  6. Checkley SA, Slade AP, Shur E. Growth hormone and other responses to clonidine in patients with endogenous depression. Br J Psychiatry. 1981;138:51–55
  7. Charney DS, Heninger GR. Abnormal regulation of noradrenergic function in panic disorders: effects of clonidine in healthy subjects and patients with agoraphobia and panic disorder. Arch Gen Psychiatry. 1986;43:1052–1054
  8. Charney DS, Heninger GR, Sternberg DE, Hafstad KM, Giddings S, Landis DH. Adrenergic receptor sensitivity in depression: effects of clonidine in depressed patients and healthy subjects. Arch Gen Psychiatry. 1982;39:290–294
  9. Fahlke C, Berggren U, Lundborg C, Balldin J. Psychopathology in alcohol withdrawal: relationship to alpha-2-adrenoreceptor function. Alcohol Alcohol. 1999;34:750–759
  10. Fahlke C, Berggren U, Balldin J. Mental well-being in alcohol withdrawal: relationship to alpha-2-adrenoreceptor function. Alcohol Alcohol. 1999;34:718–725
  11. Glue P, Sellman JD, Nicholls MG, Abbott R, Joyce PR, Nutt DJ. Studies of alpha-2-adrenoceptor function in abstinent alcoholics. Br J Addiction. 1989;84:97–102
  12. Kähkönen, S. (1997). Pharmacodynamic and pharmacokinetic aspects of propranolol, verapamil and isosorbide dinitrate during alcohol withdrawal. Doctoral Thesis, University of Helsinki, Finland, ISBN, 952-90-8422-6.
  13. Lee MA, Cameron OG, Gurguis GNM, Glitz D, Smith CB, Hariharan M, et al. Alpha-2-adrenoceptor status in obsessive-compulsive disorder. Biol Psychiatry. 1990;27:1083–1093
  14. Linnoila M, Mefford I, Nutt D, Adinoff B. Alcohol withdrawal and noradrenergic function. Ann Intern Med. 1987;107:875–889
  15. Matussek N, Ackenheil M, Herz M. The dependence of the clonidine growth hormone test on alcohol drinking habits and the menstrual cycle. Psychoneuroendocrinology. 1984;9:173–177
  16. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382–389
  17. Müller N, Hoehe M, Klein HE, Nieberle G, Kapfhammer HP, May F, et al. Endocrinological studies in alcoholics during withdrawal and after abstinence. Psychoneuroendocrinology. 1989;14:113–123
  18. Nutt D, Glue P, Molyneux S, Clark C. Alpha-2-adrenoceptor function in alcohol withdrawal: a pilot study of the effects of iv clonidine in alcoholics and normals. Alcohol Clin Exp Res. 1988;12:14–18
  19. Persson, L.O., Sjöberg, L. (1981). Mood and body feelings. Göteborg Psychological Reports No. 7. Göteborg University, Department of Psychology, 1981.
  20. Schuckit MA. Drug and alcohol abuse. In: A Clinical Guide to Diagnosis and Treatment. New York: Plenum; 1989;p. 77–95
  21. Sjöberg L, Svensson E, Persson LO. The measurement of mood. Scand J Psychol. 1979;20:1–18
  22. Snaith RP, Harrop FM, Newby DA, Teale C. Grade scores of the Montgomery–Åsberg depression and the clinical anxiety scales. Br J Psychiatry. 1986;148:599–601
  23. Svensson E, Persson L-0, Sjöberg L. Mood effects of diazepam and caffeine. Psychopharmacology. 1980;67:73–80
  24. Szmigielski A, Szmigielski H, Wejman I. The effect of prolonged ethanol administration on central alpha-2-adrenoceptors sensitivity. Pol J Pharmacol Pharm. 1989;41:263–272
  25. Tulen JHM, van de Wetering BJM, Kruijk MPCW, von Saher RA, Moleman P, Boomsma F, et al. Cardiovascular, neuroendocrine, and sedative responses to four graded doses of clonidine in a placebo-controlled study. Biol Psychiatry. 1992;32:485–500

PII: S0741-8329(00)00088-4

Alcohol
Volume 21, Issue 3 , Pages 231-237 , July 2000