Alcohol
Volume 21, Issue 3 , Pages 215-221 , July 2000

Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats

Received 4 October 1999 ,Revised 24 February 2000 ,Accepted 6 March 2000.

References 

  1. Balldin J, Berglund M, Borg S, Månsson M, Berndtsen P, Franck J, et al. A randomized 6 month double-blind placebo-controlled study of naltrexone and coping skills education programme. Alcohol Alcohol. 1997;32:325
  2. Bohn MJ, Kranzler HR, Beazoglou D, Staehler BA. Naltrexone and brief counseling to reduce heavy drinking. Am J Addictions. 1994;3:91–99
  3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254
  4. Crews ET, Overstreet DH, Kampov-Polevoi AB, Amir H. Chronic naltrexone treatment, alcohol intake, and opiate receptors in P rats. Alcohol Clin Exp Res. 1998;22:177A;(suppl.)
  5. Critcher EC, Lin CI, Patel J, Myers RD. Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone. Pharmacol Biochem Behav. 1983;18:225–229
  6. Hawkins KN, Knapp RJ, Lui GK, Gulya K, Kazmierski W, Wan YP, et al. [3H][H-d-Phe-Cys-Tyr-d-Trp-Orn-Thr-Pen-Thr-NH2]([3H]CTOP). A potent, and highly selective peptide for mu opioid receptors in rat brain. J Pharmacol Exp Ther. 1989;248:73–80
  7. Heinälä P, Alho H, Kuoppasalmi K, Sinclair JD, Kiianmaa K, Lönnqvist J. Use of naltrexone in the treatment of alcohol dependence — a double blind placebo controlled Finnish trial. Alcohol Alcohol. 1999;34:433
  8. Hyytiä P, Ingman K, Soini SL, Laitinen JT, Korpi ER. Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signaling in a genetic model of high alcohol drinking. Naunyn-Schmiedeberg's Arch Pharmacol. 1999;360:391–401
  9. Hyytiä P, Sinclair JD. Responding for oral ethanol after naloxone treatment by alcohol-preferring AA rats. Alcohol Clin Exp Res. 1993;17:631–636
  10. Kogan MJ, Verebey K, Mulé SJ. Estimation of the systemic availability and other pharmacokinetic parameters of naltrexone in man after acute and chronic oral administration. Res Commun Chem Pathol Pharmacol. 1977;18:29–34
  11. Lahti RA, Collins RJ. Chronic naloxone results in prolonged increases in opiate binding sites in brain. Eur J Pharmacol. 1978;51:185–186
  12. Lee MC, Wagner HN, Tanada S, Frost JJ, Bice AN, Dannals RF. Duration of occupancy of opiate receptors by naltrexone. J Nucl Med. 1988;29:1207–1211
  13. Månsson M, Balldin J, Berglund M, Borg S. Six-month follow-up of interaction effect between naltrexone and coping skills therapy in outpatient alcoholism treatment. Alcohol Alcohol. 1999;34:454
  14. Mason BJ, Salvato FR, Williams LD, Ritvo EC, Cutler RB. A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence. Arch Gen Psychiatry. 1999;56(8):719–725
  15. McCaul ME, Wand GS, Sullivan J, Mummford G, Quigley J. Beta-naltrexol level predicts alcohol relapse. Alcohol Clin Exp Res. 1997;21:32A
  16. Misra AL, Bloch R, Vardy J, Mulé SJ, Verebely K. Disposition of [15,16-3H]naltrexone in the central nervous system of the rat. Drug Metab Dispos. 1976;4:276–280
  17. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. Arch Gen Psychiatry. 1992;49:881–887
  18. Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Braun C, Bartus RT, Crews FT. Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding Alcohol. Clin Exp Res. 1999;23:1761–1771
  19. Pert CB, Pasternak G, Snyder SH. Opiate agonists and antagonists discriminated by receptor binding in brain. Science. 1973;182:1359–1361
  20. Reid LD, Hubbell CL. Opioids modulate rats' propensities to take alcoholic beverages. In:  Naranjo CA,  Sellers EM editor. Novel Pharmacological Interventions for Alcoholism. New York: Springer-Verlag; 1992;p. 121–134
  21. Ruffolo RR. Review: important concepts of receptor theory. J Auton Pharmacol. 1982;2:277–295
  22. Sinclair JD. The Rest Principle: A Neurophysiological Theory of Behavior. Hillsdale, NJ: Lawrence Erlbaum Associates; 1981;
  23. Sinclair JD. Drugs to decrease alcohol drinking. Ann Med. 1990;22:357–362
  24. Sinclair JD. Laboratory animal research in the discovery and development of the new alcoholism treatment using opioid antagonists. In:  Nevalainen T,  Hau J,  Sarviharju M editor. Frontiers in laboratory animal science. Scand J Lab Anim Sci. 23:1996;p. 379–390(Suppl. 1)
  25. Sinclair JD. Development in Finland of the extinction treatment for alcoholism with naltrexone. Psychiat Fennica. 1997;28:76–97
  26. Sinclair JD. From optimal complexity to the naltrexone extinction of alcoholism. In:  Hoffman R,  Sherrick MF,  Warm JS editor. Viewing Psychology as a Whole: The Integrative Science of William N. Dember. Washington, DC: Am. Psychol. Association; 1998;p. 491–508
  27. Sinclair JD. New treatment options for substance abuse from a public health viewpoint. Ann Med. 1998;30:406–411
  28. Sinclair JD, Hyytiä P, Nurmi M. Limited access paradigm: description of one method. Alcohol. 1992;9:441–444
  29. Sinclair JD, Kymäläinen O, Hernesniemi M, Shinderman MS, Maxwell S. Treatment of alcohol dependence with naltrexone utilizing an extinction protocol. In: 38th Annual Meeting, National Institute of Mental Health (NIMH)-sponsored New Clinical Drug Evaluation Unit (NCDEU) Program, Boca Raton, FL, June 10–13. 1998;No. 127, Abstracts
  30. Sinclair JD, Stenberg JH. A non-invasive, stress-free self-medication method for acute administration of pharmaceutical agents to rats. Alcohol Clin Exp Res. 1995;19:11A;(suppl.)
  31. Tang AH, Collins RJ. Enhanced analgesic of effects morphine after chronic administration of naloxone in the rat. Eur J Pharmacol. 1978;47:473–474
  32. Tempel A, Gardner EL, Zukin RS. Neurochemical and functional correlates of naltrexone-induced opiate receptor upregulation. J Pharmacol Exp Ther. 1985;232:439–444
  33. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry. 1992;49:876–880
  34. Yoburn BC, Luke MC, Pasternak GW, Inturrisi CE. Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DAFLE. Life Sci. 1988;43:1319–1324
  35. Yoburn BC, Sierra V, Lutfy K. Chronic opioid antagonist treatment: assessment of receptor upregulation. Eur J Pharmacol. 1989;170:193–200
  36. Zukin RS, Sugarman JR, Fitz-Syage ML, Gardner EL, Zukin SR, Gintzler AR. Naltrexone-induced opiate receptor supersensitivity. Brain Res. 1982;245:285–292

PII: S0741-8329(00)00091-4

Alcohol
Volume 21, Issue 3 , Pages 215-221 , July 2000

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