Alcohol
Volume 21, Issue 3 , Pages 239-243 , July 2000

Ethanol exacerbates T cell dysfunction after thermal injury

  • Mashkoor A Choudhry

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Surgery, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Corresponding Author InformationCorresponding author. Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA. Tel.: +1-708-327-2451; fax: +1-708-327-2813
    • ,
  • Kelly A.N Messingham

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • ,
  • Shahla Namak

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • ,
  • Alessandra Colantoni

      Affiliations

    • Department of Medicine, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • ,
  • Christine V Fontanilla

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • ,
  • Lisa A Duffner

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • ,
  • Mohammed M Sayeed

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Surgery, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Physiology, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • ,
  • Elizabeth J Kovacs

      Affiliations

    • Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Surgery, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    • Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA

Received 13 January 2000 ,Revised 23 March 2000 ,Accepted 30 March 2000.

References 

  1. Ahmad S, Choudhry MA, Shankar R, Sayeed MM. Transforming growth factor-β negatively modulates T-cell responses in sepsis. FEBS Lett. 1997;402:213–218
  2. Bone RC. Gram-negative sepsis: a dilemma of modern medicine. Clin Microbiol Rev. 1993;6:57–68
  3. Choudhry MA, Ahmad S, Ahmed Z, Sayeed MM. Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram negative sepsis. Immunol Lett. 1999;67:125–130
  4. Choudhry MA, Ahmad S, Sayeed MM. Role of Ca2+ in prostaglandin E2-induced T lymphocyte proliferative suppression in sepsis. Infect Immun. 1995;63:3101–3105
  5. Choudhry MA, Sayeed MM. Calcium signaling restitution prevents T cell proliferative suppression by PGE2. Shock. 1996;6:101–105
  6. Choudhry MA, Uddin S, Sayeed MM. Prostaglandin E2 modulation of P59fyn tyrosine kinase in T lymphocytes during sepsis. J Immunol. 1998;160:929–935
  7. Conboy K, Welage LS, Walawander CA, Duffy LC, Welliver RC, Zielezny MA, et al. Sepsis syndrome and associated sequelae in patients at high risk for gram-negative sepsis. Pharmacotherapy. 1995;15:66–77
  8. Cook RT. Alcohol abuse, alcoholism, and damage to the immune system — a review. Alcohol: Clin Exp Res. 1998;22:1927–1942
  9. Decker D, Schondorf M, Bidlingmaier F, Hirner A, von Ruecker AA. Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to trauma. Surgery. 1996;119:316–325
  10. Domiati-Saad R, Jerrells TR. The influence of age on blood alcohol levels and ethanol-associated immunosuppression in a murine model of ethanol consumption. Alcohol: Clin Exp Res. 1993;17:382–388
  11. Faist E, Schinkel C, Zimmer S. Update on the mechanisms of immune suppression of injury and immune modulation. World J Surg. 1996;20:454–459
  12. Faunce D, Gregory MS, Kovacs EJ. The effect of acute ethanol exposure on cellular immune responses in a murine model of thermal injury. J Leukocyte Biol. 1997;62:733–740
  13. Faunce D, Gregory MS, Kovacs EJ. Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6. Shock. 1998;10:135–140
  14. Faunce D, Gregory MS, Kovacs EJ. Glucocorticoids protect against suppression of T cell responses in a murine model of acute ethanol exposure and thermal injury by regulating IL-6. J Leukocyte Biol. 1998;64:724–732
  15. Hingson R, Howland J. Alcohol and non-traffic unintended injuries. Addiction. 1993;88:877–883
  16. Hoyt DB, Junger WG, Loomis WH, Liu FC. Effects of trauma on immune cell function: impairment of intracellular calcium signaling. Shock. 1994;2:23–28
  17. Jaysinghe R, Gianutsos G, Hubbard A. Ethanol-induced suppression of cell mediated immunity in mouse. Alcohol: Clin Exp Res. 1992;16:331–335
  18. Jerrells TR. Immunodeficiency associated with ethanol abuse. Adv Exp Med Biol. 1991;288:229–236
  19. Jones JD, Barber B, Engrav L, Heimbach D. Alcohol use and burn injury. J Burn Care Rehabil. 1991;12:148–152
  20. Kawakami M, Switzer BR, Herzog SR, Meyer AA. Immune suppression after acute ethanol ingestion and thermal injury. J Surg Res. 1991;51:210–215
  21. Lazaron V, Barke RA. Gram-negative bacterial sepsis and the sepsis syndrome. Urol Clin North Am. 1999;26:687–699
  22. McGill V, Kowal-Vern A, Fisher SG, Kahn S, Gamelli RL. The impact of substance use on mortality and morbidity from thermal injury. J Trauma. 1995;38:931–934
  23. Nakanishi T, Nishi Y, Sato EF, Ishii M, Hamada T, Inoue M. Thermal injury induces thymocyte apoptosis in the rat. J Trauma. 1998;44:143–148
  24. Napolitano LM, Koruda MJ, Zimmerman K, McCowan K, Chang J, Meyer AA. Chronic ethanol intake and burn injury: evidence for synergistic alteration in gut and immune integrity. J Trauma. 1995;38:198–207
  25. O'Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, Rodrick ML. Major injury leads to predominance of T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg. 1995;222:482–492
  26. Slukvin II, Jerrells TR. Different pathways of in vitro ethanol-induced apoptosis in thymocytes and splenic T and B lymphocytes. Immunopharmacology. 1995;31:43–57
  27. Smith GS, Kraus JF. Alcohol and residential, recreational, and occupational injuries: a review of the epidemiologic evidence. Annu Rev Public Health. 1988;9:99–121
  28. Soderstrom CA, Dischinger PC, Kerns TJ, Kufera JA, McDuff DR, Gorelick DA, et al. Screening trauma patients for alcoholism according to NIAAA guidelines with alcohol disorders identification test questions. Alcohol: Clin Exp Res. 1998;22:1470–1475
  29. Szabo G. Monocytes, alcohol use and altered immunity. Alcohol: Clin Exp Res. 1998;22:216S–219S
  30. Thal E, Bost RO, Anderson RJ. Effects of alcohol and other drugs on traumatized patients. Arch Surg. 1985;120:708–712
  31. Waltenbaugh C, Vasquez K, Peterson JD. Alcohol consumption alters antigen-specific Th1 responses: mechanism of deficit and repair. Alcohol: Clin Exp Res. 1998;22:220S–223S
  32. Wolf SE, Ikeda H, Matin S, Debroy MA, Rajaraman S, Herndon DN, et al. Cutaneous burn increases apoptosis in the gut epithelium of mice. J Am Coll Surg. 1999;188:10–16

PII: S0741-8329(00)00093-8

Alcohol
Volume 21, Issue 3 , Pages 239-243 , July 2000

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