Alcohol
Volume 22, Issue 1 , Pages 19-24 , August 2000

Conditioned place aversion to the “hangover” phase of acute ethanol administration in the rat

  • Andrew C Morse

      Affiliations

    • Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    • Department of Anesthesiology, University of California San Diego and San Diego VA Medical Center, San Diego, CA 92093, USA
    • Corresponding Author InformationCorresponding author. Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, Maildrop CVN-7, La Jolla, CA 92037, USA. Tel.: +1-858-784-7305 ext. 4492; fax: +1-858-784-7405
    • ,
  • Gery Schulteis

      Affiliations

    • Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    • Department of Anesthesiology, University of California San Diego and San Diego VA Medical Center, San Diego, CA 92093, USA
    • ,
  • Frank A Holloway

      Affiliations

    • Psychobiology Research Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    • ,
  • George F Koob

      Affiliations

    • Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA

Received 19 November 1999 ,Revised 15 May 2000 ,Accepted 22 May 2000.

References 

  1. Amit Z, Smith BR. A multidimensional examination of the positive reinforcing properties of acetaldehyde. Alcohol. 1985;1:367–370
  2. Baldwin HA, Britton KT, Koob GF. Behavioral effects of CRF. In:  Pfaff DW,  Ganten D editor. Behavioral Aspects of Neuroendocrinology. New York: Springer-Verlag; 1990;p. 1–14
  3. Baldwin HA, Rassnick S, Rivier J, Koob GF, Britton KT. CRF antagonist reverses the ‘anxiogenic’ response to ethanol withdrawal in the rat. Psychopharmacology. 1991;103:227–232
  4. Bozarth MA. Methods of Assessing the Reinforcing Properties of Abused Drugs. New York: Springer-Verlag; 1987;
  5. Brown ZW, Amit Z, Smith B, Rockman GE. Differential effects on conditioned taste aversion learning with peripherally and centrally administered acetaldehyde. Neuropharmacology. 1978;17:931–935
  6. Ciccocioppo R, Panocka I, Froldi R, Quitadamo E, Massi M. Ethanol induces conditioned place preference in genetically selected alcohol-preferring rats. Psychopharmacology. 1999;141(3):235–241
  7. Cunningham CL. Flavor and location aversions produced by ethanol. Behav Neural Biol. 1979;27:362–367
  8. Cunningham CL. Spatial aversion conditioning with ethanol. Pharmacol Biochem Behav. 1981;14:263–264
  9. Cunningham CL, Niehus JS, Bachtold JF. Ambient temperature effects on taste aversion conditioned by ethanol: contribution of ethanol-induced hypothermia. Alcohol Clin Exp Res. 1992;16(6):1117–1124
  10. Cunningham CL, Niehus JS, Noble D. Species difference in sensitivity to ethanol's hedonic effects. Alcohol. 1993;10:97–102
  11. Dickinson SD, Cunningham CL. Altered ambient temperature and ethanol-induced conditioned place preference in mice. Alcohol. 1998;16:13–18
  12. Freund G. Comparison of alcohol dependence, withdrawal, and hangover in humans and animals. In:  Eriksson K,  Sinclair JD,  Kiianmaa K editor. Animal Models in Alcohol Research. New York: Academic Press; 1980;p. 293–308
  13. Gauvin DV, Briscoe RJ, Baird TJ, Vallett M, Holloway FA. The paradoxical hedonic valence of acute ethanol withdrawal (hangover) states in rats: place and taste conditioning. Alcohol. 1997;14:261–268
  14. Gauvin DV, Briscoe RJ, Goulden KL, Holloway FA. Aversive attributes of ethanol can be attenuated by dyadic social interaction in the rat. Alcohol. 1994;11:247–251
  15. Gauvin DV, Cheng EY, Holloway FA. Recent developments in alcoholism: Biobehavioral correlates. In:  Galanter M editors. Recent Developments in Alcoholism: Ten Years of Progress. New York: Plenum; 1993;p. 281–304
  16. Gauvin DV, Goulden KL, Holloway FA. State-dependent stimulus control: cueing attributes of ethanol “hangover” in rats. Alcohol Clin Exp Res. 1993;17(6):1210–1214
  17. Gauvin DV, Holloway FA. Historical factors in the development of EtOH-conditioned place preference. Alcohol. 1992;9:1–7
  18. Gauvin DV, Youngblood BD, Holloway FA. The discriminative stimulus properties of acute ethanol withdrawal (hangover) in rats. Alcohol Clin Exp Res. 1992;16(2):336–341
  19. Gevaerd MS, Takahashi RN. Interaction of mazindol with alcohol in mice. Addict Biol. 1996;1:303–307
  20. Goldstein DB. Animals studies of alcohol withdrawal reactions. In:  Israel Y,  Glaser FB,  Kalant H editor. Research Advances in Alcohol and Drug Problems. Vol. 4:New York: Plenum; 1978;p. 77–109
  21. Goldstein DB. Pharmacology of Alcohol. New York: Oxford Univ. Press; 1983;
  22. Goodwin DW. In:  Lowinson JH,  Ruiz P,  Millman RB,  Langrod JG editor. Substance Abuse: A Comprehensive Textbook. Baltimore: Williams & Wilkins; 1992;p. 144–151
  23. Holloway FA, King DA, Bedingfield JB, Gauvin DV. The role of context in ethanol tolerance and subsequent hedonic effects. Alcohol. 1992;9:109–116
  24. Idemudia SO, Bhadra S, Lal H. The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxin. Neuropsychopharmacology. 1989;2:115–122
  25. Kissin B, Beglieter H. The Biology of Alcoholism. New York: Plenum; 1971;
  26. Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science. 1988;242:715–723
  27. Koob GF, Markou A, Weiss F, Schulteis G. Opponent process and drug dependence: neurobiological mechanisms. Sem Neurosci. 1993;5:351–358
  28. Koob GF, Stinus L, Le Moal M, Bloom FE. Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. Neurosci Biobehav Rev. 1989;13:135–140
  29. Lal H, Prather PL, Rezazadeh SM, Lal H. Mianserin in the treatment of ethanol withdrawal in the rat: prevention of behaviors indicative of anxiety. Psychopharmacol Bull. 1991;27(3):285–289
  30. Majchrowicz E. Comparison of ethanol withdrawal syndrome in humans and rats. In:  Gross MM editors. Alcohol Intoxication and Withdrawal: III. Studies in Alcohol Dependence. New York: Plenum; 1977;p. 15–23
  31. Majchrowicz E. Reversal in central nervous system function during ethanol withdrawal in humans and experimental animals. Fed Proc. 1981;40:2065–2072
  32. Majchrowicz E, Noble EP. Biochemistry and Pharmacology of Ethanol. New York: Plenum; 1979;
  33. Pinel JPJ, Mucha RF. Increased susceptibility to seizures following brief exposure to alcohol: hangover or artifact. In:  Eriksson K,  Sinclair JD,  Kiianmaa K editor. Animal Models in Alcohol Research. New York: Academic Press; 1980;p. 413
  34. Prather PL, Rezazadeh SM, Lai H. Mianserin in the treatment of ethanol withdrawal in the rat: prevention of behaviors indicative of anxiety. Psychopharmacol Bull. 1991;27(3):285–289
  35. Risinger FO. Fluoxetine's effects on ethanol's rewarding, aversive and stimulus properties. Life Sci. 1997;61:PL235–PL242
  36. Risinger FO, Oakes RA. Dose and conditioning trial-dependent ethanol-induced conditioned place preference in Swiss Webster mice. Pharmacol Biochem Behav. 1996;55:117–123
  37. Sanders B. Withdrawal-like signs induced by a single administration of ethanol in mice that differ in ethanol sensitivity. Psychopharmacology. 1980;68:109–113
  38. Schechter MD. Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats. Alcohol. 1992;9:185–188
  39. Schechter MD, Krimmer EC. Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats. Psychopharmacology (Berlin). 1992;107:564–568
  40. Schull JA. Conditioned opponent theory of Pavlovian conditioning and habituation. In:  Bower GH editors. The Psychology of Learning and Motivation: Advances in Research and Theory. New York: Academic Press; 1979;p. 57–90
  41. Schulteis G, Koob GF. Reinforcement processes in opiate addiction: a homeostatic model. Neurochem Res. 1996;21(11):1437–1454
  42. Sherman J, Rusiniak KW, Garcia J. Alcohol-ingestive habits. The role of flavor and effect. Recent Dev Alcohol. 1984;2:59–79
  43. Smith BR, Amit Z, Splawinsky J. Conditioned place preference induced by intraventricular infusions of acetaldehyde. Alcohol. 1984;1:193–195
  44. Solomon RL. The opponent-process theory of acquired motivation: the costs of pleasure and the benefits of pain. Am Psychol. 1980;35:691–712
  45. Staiger PK, White JM. Conditioned alcohol-like and alcohol-opposite responses in humans. Psychopharmacology. 1988;95:87–91
  46. Stewart RB, Murphy JM, McBride WJ, Lumeng L, Li TK. Place conditioning with alcohol in alcohol-preferring and -nonpreferring rats. Pharmacol Biochem Behav. 1996;53:487–491
  47. Stinus L, Le Moal M, Koob GF. Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience. 1990;37:767–773
  48. Suzdak PD, Paul SM. Ethanol stimulates GABA receptor-mediated chloride ion flux in vitro: possible relationship to the anxiolytic and intoxicating actions of alcohol. 1988;
  49. Suzuki T, Shiozake Y, Moriizumi T, Misawa M. Establishment of the ethanol-induced place preference in rats. Jpn J Alcohol Drug Depend. 1992;27:111–123
  50. Swerdlow NR, Gilbert D, Koob GF. Conditioned drug effects on spatial preference. In:  Boulton AA,  Baker GB,  Greenshaw AJ editor. Psychopharmacology. Neuromethods. Vol. 13:Clifton, NJ: Humana Press; 1989;p. 399–446
  51. Tzschentke TM. Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol. 1998;56(6):613–672
  52. Van der Kooy D, O'Shaughnessy M, Mucha RF, Kalant H. Motivational properties of ethanol in naı̈ve rats as studied by place conditioning. Pharmacol Biochem Behav. 1983;19:441–445
  53. Ylikahri RH, Huttunen MO, Eriksson CJ, Nikkila EA. Metabolic studies on the pathogenesis of hangover. Eur J Clin Invest. 1974;4:93–100

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Alcohol
Volume 22, Issue 1 , Pages 19-24 , August 2000

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