Alcohol
Volume 22, Issue 1 , Pages 7-17 , August 2000

Differential responsiveness to alcohol odor in human neonates: Efects of maternal consumption during gestation

  • Ana E Faas

      Affiliations

    • Servicio de Neonatologı́a, Hospital Universitario de Maternidad y Neonatologı́a, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina
    • Instituto de Investigación Médica Mercedes y Martı́n Ferreyra, 5000 Córdoba, Argentina
    • Corresponding Author InformationCorresponding author. Instituto de Investigación Médica Mercedes y Martı́n Ferreyra, Casilla de Correo 389, 5000 Córdoba, Argentina. Fax: +54-51-69-5163
    • ,
  • Elvio D Spontón

      Affiliations

    • Servicio de Neonatologı́a, Hospital Universitario de Maternidad y Neonatologı́a, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina
    • ,
  • Pedro R Moya

      Affiliations

    • Servicio de Neonatologı́a, Hospital Universitario de Maternidad y Neonatologı́a, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina
    • ,
  • Juan C Molina

      Affiliations

    • Also corresponding author.
    • Instituto de Investigación Médica Mercedes y Martı́n Ferreyra, 5000 Córdoba, Argentina

Received 13 September 1999 ,Revised 14 April 2000 ,Accepted 22 May 2000.

References 

  1. Blass EM, Teicher MH. Suckling. Science. 1980;210:15–22
  2. Brazelton TB. Behavioral competence of the newborn infant. In:  Avery GB editors. Neonatology, Pathophysiology and Management of the Newborn. 3rd edn.. Berlin: Libermed Verlag; 1987;p. 392–412
  3. Caza P, Spear N. Short term exposure to an odor increases its subsequent preference in preweanling rats: a descriptive profile of the phenomenon. Dev Psychobiol. 1984;17:407–422
  4. Chotro MG, Córdoba NE, Molina JC. Acute prenatal experience with ethanol in the amniotic fluid: interactions with aversive and appetitive ethanol orosensory learning in the rat pup. Dev Psychobiol. 1992;24:431–451
  5. Chotro MG, Molina JC. Bradycardiac responses elicited by ethanol odor in rat neonates: influence of in utero experience with ethanol. Psychopharmacology. 1992;106:491–496
  6. Coles CD, Platzman KA, Raskind-Hood CL, Brown RT, Falek A, Smith IE. A comparison of children affected by prenatal alcohol exposure and attention deficit, hyperactivity disorder. Alcohol Clin Exp Res. 1997;21:150–161
  7. Cooper A, Hawthorn S. Modification of flavor preference by olfactory pre-exposure in normal and zinc sulfate treated mice. Bull Psychonomic Soc. 1977;10:369–379
  8. Craig KD, Whitfield MF, Grunau RVE, Linton J, Hadjistavropoulos HD. Pain in the preterm neonate: behavioural and physiological indices. Pain. 1993;52:287–299
  9. Dawson DA, Grant BF, Chow PS. Gender differences in alcohol intake. In:  Hunt WA,  Zakhari S editor. Stress, Gender and Alcohol-Seeking Behavior. Bethesda, MD: The Institute; 1995;p. 3–21National Institute on Alcohol Abuse and Alcoholism Research. Monograph No. 29, NIH Pub. No. 95-3893
  10. Domı́nguez HD, Chotro MG, Molina JC. Alcohol in the amniotic fluid prior to cesarean delivery: effects of subsequent exposure to the drug's odor upon alcohol responsiveness. Behav Neural Biol. 1993;60:129–138
  11. Dufour MC. Assessing alcohol-associated risks bases on alcohol consumption. Alcohol World Health and Research. 1996;20:148–151
  12. Engen T, Lipsitt LP. Decrement and recovery of responses to olfactory stimuli in the human neonate. J Comp Physiol Psychol. 1965;59:312–316
  13. Faas AE, Spontón ED, Moya PR, Molina JC. Nonassociative learning comprising alcohol odor in human neonates. Alcohol Clin Exp Res. 1996;20:107a;Abstract No. 619
  14. Hall WG. The ontogeny of ingestive behavior. Changing control of components in the feeding sequence. In:  Stricker EM editors. Handbook of Behavioral Neurology: Food and Water Intake. New York: Plenum; 1990;p. 77–123
  15. Hepper PG. The behavior of the fetus as an indicator of neural functioning. In:  Lecanuet J,  Fifer W,  Krasnegor N,  Smotherman W editor. Fetal Development: A Psychobiological Perspective. Hillsdale, NJ: Lawrence Erlbaum; 1995;p. 405–417
  16. Leader LR. The potential value of habituation in the prenate. In:  Lecanuet J,  Fifer W,  Krasnegor N,  Smotherman W editor. Fetal Development: A Psychobiological Perspective. Hillsdale, NJ: Lawrence Erlbaum; 1995;p. 383–404
  17. Leon M. Plasticity of olfactory output circuits related to early olfactory learning. Trends Neurosci. 1987;10:434–438
  18. Leon M, Wilson DA, Guthrie KM. Plasticity in the developing olfactory system. In:  Davis JL,  Eichenbaum H editor. Olfaction: A Model System for Computational Neuroscience. Cambridge, MA: The MIT Press; 1991;
  19. Mariategui, J., & Adis Castro, G. (1970). Epidemiologı́a psiquiátrica en América Latina. Servicio Nacional de Salud, Universidad de Chile. Acta-Fondo para la Salud Mental.
  20. Menella JA, Beauchamp GK. The transfer of alcohol to human milk. Effects on flavor and the infant's behavior. New Engl J Med. 1991;352:981–985
  21. Menella JA, Beauchamp GK. Effects of beer on breast-fed infants. JAMA. 1993;269:1635–1636
  22. Menella JA, Beauchamp GK. Infants' suckling responses to the flavor of alcohol in mothers' milk. Alcohol Clin Exp Res. 1997;21:581–585
  23. Menella JA, Beauchamp GK. Infants' exploration of scented toys: effects of prior experiences. Chem Senses. 1998;23:11–17
  24. Molina JC, Chotro MG. Association between chemosensory stimuli and cesarean delivery in rat fetuses: neonatal presentation of similar stimuli increases motor activity. Behav Neural Biol. 1991;55:42–60
  25. Molina J, Chotro C, Domı́nguez MG. Fetal alcohol learning derived from ethanol contamination of the prenatal environment. In:  Lecanuet J,  Fifer W,  Krasnegor N,  Smotherman W editor. Fetal Development: A Psychobiological Perspective. Hillsdale, NJ: Lawrence Erlbaum Associates; 1995;p. 419–438
  26. Molina JC, Domı́nguez HD, López MF, Pepino MY, Faas AE. The role of fetal and infantile experience with alcohol in later recognition and acceptance patterns of the drug. In:  Hannigan JH,  Spear N,  Spear L,  Goodlett C editor. Alcohol and Alcoholism: Brain and Development. Mahwah, NJ: Lawrence Erlbaum Associates; 1999;p. 199–228
  27. Muller-Schwarze D, Muller-Schwarze C. Olfactory imprinting in a precocial mamal. Nature. 1971;229:55–56
  28. Noll RB, Zucker RA, Greenberg GS. Identification of alcohol by smell among preschoolers: evidence for early socialization about drugs in the home. Child Dev. 1990;61:1520–1527
  29. Ronca AE, Alberts JR. Heart rate development and sensory-evoked cardiac responses in perinatal rats. Physiol Behav. 1990;47:1075–1082
  30. Scher MS, Richardson GA, Robles N, Geva D, Goldschmidt L, Dahl RE, et al. Effects of prenatal substance exposure: altered maturation of visual evoked potentials. Pediatr Neurol. 1998;18:236–243
  31. Smotherman WP. Odor aversion learning by the rat fetus. Physiol Behav. 1982;29:769–771
  32. Smotherman WP, Robinson SR. Rat fetuses respond to chemical stimuli in gas phase. Physiol Behav. 1990;47:863–868
  33. Smotherman WP, Robinson SR. Habituation in the rat fetus. Q J Exp Psychol. 1992;44B:215–230
  34. Soussignan R, Schaal B, Marlier L, Jiang T. Facial and autonomic responses to biological and artificial olfactory stimuli in human neonates: re-examining early hedonic discrimination of odors. Physiol Behav. 1997;62:745–758
  35. Stratton K, Howe C, Battaglia F. Fetal Alcohol Syndrome. Diagnosis, Epidemiology, Prevention and Treatment. Washington, DC: National Academy Press; 1996;
  36. Thompson RF, Glandsman DL. Neural and behavioural mechanisms of habituation and sensitisation. In:  Tighe TJ,  Leaton RN editor. Habituation. Hillsdale, NJ: Lawrence Erlbaum Associates; 1966;p. 49–93
  37. U.S. Department of Health and Human Services (1997). Ninth special report to the U.S. Congress on: Alcohol and Health. Secretary of Health and Human Services.
  38. Varendi H, Porter RH, Winberg J. Attractiveness of amniotic fluid odor: evidence of prenatal olfactory learning?. Acta Paediatr. 1996;85:1223–1227
  39. Varendi H, Porter RH, Winberg J. Natural odour preferences of newborn infants change over time. Acta Paediatr. 1997;86:985–990
  40. Wilson DA, Sullivan RM. Neurobiology of associative learning in the neonate: early olfactory learning. Behav Neural Biol. 1994;61:1–18
  41. Winberg J, Porter RH. Olfaction and human neonatal behaviour: clinical implications. Acta Paediatr. 1998;87:6–10
  42. Woo CC, Oshita MH, Leon M. A learned odor decreases the number of Fos-inmunopositive granule cells in the olfactory bulb of young rats. Brain Res. 1996;716:149–156

PII: S0741-8329(00)00103-8

Alcohol
Volume 22, Issue 1 , Pages 7-17 , August 2000

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