Alcohol
Volume 23, Issue 2 , Pages 71-81 , February 2001

Use of rat models to mimic alterations in iron homeostasis during human alcohol abuse and cirrhosis

  • Martha J Gentry-Nielsen

      Affiliations

    • Departments of Internal Medicine and Medical Microbiology and Immunology, Creighton University School of Medicine, University of Nebraska Medical Center and VA Medical Center, Omaha, NE 68105, USA
    • ,
  • Laurel C Preheim

      Affiliations

    • Departments of Internal Medicine and Medical Microbiology and Immunology, Creighton University School of Medicine, University of Nebraska Medical Center and VA Medical Center, Omaha, NE 68105, USA
    • ,
  • Katrina N Lyman

      Affiliations

    • Departments of Internal Medicine and Medical Microbiology and Immunology, Creighton University School of Medicine, University of Nebraska Medical Center and VA Medical Center, Omaha, NE 68105, USA
    • ,
  • Kathleen H McDonough

      Affiliations

    • The Alcohol Research Center and Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USA
    • ,
  • Barry J Potter

      Affiliations

    • The Alcohol Research Center and Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-504-568-3385; fax: +1-504-568-6158

Received 24 September 2000 ,Revised 27 September 2000 ,Accepted 5 October 2000.

References 

  1. Aleynik MK, Leo MA, Aleynik SI, Lieber CS. Polyenyl-phosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease. Alcohol: Clin Exp Res. 1999;23:96–100
  2. Anghileri LJ, Esposito M, Fulcheri E, Zicca A, Cadoni A, Thouvenot P. Iron–ethanol synergism and pathological liver transformation. In Vivo. 1999;13:13–20
  3. Barry M. Iron and chronic liver disease. J R Coll Physicians Lond. 1973;8:52–62
  4. Batey R, Patterson F. Carbohydrate-deficient transferrin in the ethanol-consuming rat model. Alcohol. 1991;8:487–490
  5. Baynes R, Bezwoda W, Bothwell T, Khan Q, Mansoor N. The non-immune inflammatory response: serial changes in plasma iron, iron binding capacity, lactoferrin, ferritin and C-reactive protein. Scan J Clin Lab Invest. 1986;46:695–704
  6. Birgegard G, Hallgren R, Killander A, Stromberg A, Venge P, Wide L. Serum ferritin during infection. A longitudinal study. Scan J Haematol. 1978;21:333–340
  7. Bothwell TH, Charlton RW, Cook JD, Finch CA. In: Iron Metabolism in Man. Oxford: Blackwell; 1979;p. 443–446
  8. Burke W, Press N, McDonnell SM. Hemochromatosis: genetics helps to define a multifactorial disease. Clin Gene. 1998;54:1–9
  9. Chapman RW, Morgan MY, Bell R, Sherlock S. Hepatic iron uptake in alcoholic liver disease. Gastroenterology. 1983;84:143–147
  10. Chapman RW, Morgan MY, Laulicht M, Hoffbrand AV, Sherlock S. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci. 1982;27:909–916
  11. Conrad ME, Barton JC. Anemia and iron kinetics in alcoholism. Semin Hematol. 1980;17:149–163
  12. Conte D, Piperno A, Mandelli C, Fargion S, Cesana M, Brunelli L, et al  Clinical, biochemical and histological features of primary haemochromatosis: a report of 67 cases. Liver. 1986;6:310–315
  13. Cotler SJ, Bronner MP, Press RD, Carlson TH, Perkins JD, Emond MJ, et al. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index. J Hepatol. 1998;29:257–262
  14. Eichner ER, Hillman RS. The evolution of anemia in alcoholic patients. Am J Med. 1971;50:218–232
  15. Fargion S, Mandelli C, Piperno A, Cesana B, Fracanzani AL, Fraquelli M, et al. Survival and prognostic factors in 212 Italian patients with genetic hemochromatosis. Hepatology. 1992;15:655–659
  16. Fletcher LM. Alcohol and iron: one glass of red or more?. J Gastroenterol Hepatol. 1996;11:1039–1041
  17. Friedman IM, Kraemer HC, Mendoza FS, Hammer LD. Elevated serum iron concentration in adolescent alcohol users. Am J Dis Child. 1988;142:156–159
  18. George DK, Powell LW, Losowsky MS. The haemochromatosis gene: a co-factor for chronic liver disease?. J Gastroenterol Hepatol. 1999;14:745–749
  19. Halliday JW, Gera KL, Powell LW. Solid phase radioimmunoassay for serum ferritin. Clin Chim Acta. 1975;58:207–214
  20. Harlow E, Lane D. In: Antibodies, a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1988;p. 586–587Chapter 14
  21. Herbert V, Jayatilleke E, Shaw S, Rosman AS, Giardina P, Grady RW, et al. Serum ferritin iron, a new test, measures human body iron stores unconfounded by inflammation. Stem Cells. 1997;15:291–296
  22. Irving MG, Halliday JW, Powell LW. Association between alcoholism and increased hepatic iron stores. Alcohol: Clin Exp Res. 1988;12:7–13
  23. Jakobovits AW, Morgan MY, Sherlock S. Hepatic siderosis in alcoholics. Dig Dis Sci. 1979;24:305–310
  24. Kaufman N, Klavins JV, Kinney TD. Excessive iron absorption in rats fed low-protein, high-fat diets. Lab Invest. 1958;7:369–376
  25. Kimber C, Deller DJ, Ibbotson RN, Lander H. The mechanism of anemia in chronic liver disease. Quart J Med. 1965;34:33–64
  26. Landrigan J, Patterson F, Batey R. A histological study of the use of agar as a delivery vehicle for alcohol or iron to rats. Alcohol. 1989;6:173–178
  27. Lang CH, Fan J, Lipton BP, Potter BJ, McDonough KH. Modulation of the insulin-like growth factor system by chronic alcohol feeding. Alcohol: Clin Exp Res. 1998;22:823–829
  28. LeSage GD, Baldus WP, Fairbanks VF, Baggenstoss AH, McCall JT, Moore SB, et al. Hemochromatosis: genetic or alcohol-induced?. Gastroenterology. 1983;84:1471–1477
  29. Lescoat G, Loreal O, Moirand R, Dezier JF, Pasdeloup N, Deugnier Y, et al. Iron induction of ferritin synthesis and secretion in human hepatoma cell (Hep G2) cultures. Liver. 1989;9:179–185
  30. Lieber CS, DeCarli LM. The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol: Clin Exp Res. 1982;6:523–531
  31. Lindenbaum J, Lieber CS. Hematologic effects of alcohol in man in the absence of nutritional deficiency. New Engl J Med. 1969;281:333–338
  32. Lundin L, Hallgren R, Birgegard G, Wide L. Serum ferritin in alcoholics and the relation to liver damage, iron state and erythropoietic activity. Acta Med Scand. 1981;209:327–331
  33. Mellencamp MA, Preheim LC. Pneumococcal pneumonia in a rat model of cirrhosis: effects of cirrhosis on pulmonary defense mechanisms against Streptococcus pneumoniae. J Infect Dis. 1991;163:102–108
  34. Mi L-J, Mak KM, Lieber CS. Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC). Alcohol: Clin Exp Res. 2000;24:207–212
  35. Miles LE, Lipschitz DA, Bieber CP, Cook JD. Measurement of serum ferritin by a 2-site immunoradiometric assay. Anal Biochem. 1974;61:209–224
  36. Miralles Garcia JM, de Castro del Pozo S. Iron deposits in chronic alcoholics. Special studies in relation to the iron contained in red wine. Acta Hepatogastroenterol. 1976;23:10–19
  37. Moirand R, Lescoat G, Delamaire D, Lauvin L, Campion JP, Deugnier Y, et al. Increase in glycosylated and nonglycosylated serum ferritin in chronic alcoholism and their evolution during alcohol withdrawal. Alcohol: Clin Exp Res. 1991;15:963–969
  38. Moirand R, Lescoat G, Hubert N, Dezier JF, Pasdeloup N, Brissot P. Alcohol induction of ferritin expression in a human hepatoblastoma cell line (HEP G2). Alcohol: Clin Exp Res. 1990;14:847–852
  39. Morton AG, Tavill AS. The control of hepatic iron uptake: correlation with transferrin synthesis. Br J Haematol. 1978;39:497–507
  40. Niemela O, Parkkila S, Britton RS, Brunt E, Janney C, Bacon B. Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury. J Lab Clin Med. 1999;133:451–460
  41. Nunes R, Beloqui O, Potter BJ, Berk PD. Iron uptake from transferrin by isolated hepatocytes: effect of ethanol. Biochem Biophys Res Commun. 1984;125:824–830
  42. Olynyk J, Hall P, Reed W, Williams P, Kerr R, Mackinnon M. A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J Hepatol. 1995;22:671–676
  43. O'Shea MJ, Kershenobich D, Tavill AS. Effects of inflammation on iron and transferrin metabolism. Br J Haematol. 1973;25:707–714
  44. Pietrangelo A, Rocchi E, Ferrari A, Ventura E, Cairo G. Regulation of hepatic transferrin, transferrin receptor and ferritin genes in human siderosis. Hepatology. 1991;14:1083–1089
  45. Potter BJ. Alcohol and hepatic iron homeostasis. In:  Watson RR editors. Drug and alcohol abuse reviews: vol. 2. Liver Pathology and Alcohol. Totowa, NJ: Humana Press; 1991;p. 1–60
  46. Potter BJ. Carbohydrate-deficient transferrin and the detection of alcohol abuse: a horse of a different color?. Alcohol: Clin Exp Res. 1994;18:774–777
  47. Potter BJ. Development of the agar block method of alcohol feeding in male rats. Alcohol: Clin Exp Res. 1996;20:13A
  48. Potter BJ, Chapman RW, Nunes RM, Sorrentino D, Sherlock S. Transferrin metabolism in alcoholic liver disease. Hepatology. 1985;5:714–721
  49. Potter BJ, McHugh TA, Beloqui O. Iron uptake from transferrin and asialotransferrin by hepatocytes from chronically alcohol-fed rats. Alcohol: Clin Exp Res. 1992;16:810–815
  50. Powell LW. Changing concepts in haemochromatosis. Postgrad Med J. 1970;46:200–209
  51. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology. 1975;68:525–533
  52. Rothschild MA, Oratz M, Morland J, Schreiber SS, Burks A, Martin B. Effects of ethanol on protein synthesis and secretion. Pharmacol, Biochem Behav. 1980;13(Suppl. 1):31–36
  53. Sabesin SM, Thomas LB. Parenchymal siderosis in patients with pre-existing portal cirrhosis. A pathological entity simulating idiopathic and transfusional hemochromatosis. Gastroenterology. 1964;46:447–485
  54. Sankaran H, Larkin EC, Rao GA. Unsaturated fat and low energy intake induce whereas an increment in energy intake ameliorates fatty liver during prolonged alcohol consumption by rats. J Nutr. 1994;124:110–116
  55. Sorrell MF, Nauss JM, Donahue TM, Tuma DJ. Effects of chronic ethanol administration on hepatic glycoprotein secretion in the rat. Gastroenterology. 1983;84:580–586
  56. Speck B. Die tagesschwankungen des serumeinsens und der latenten eisenbindungskapazitat bei hepatitis, leberzirrhose, alkoholismus, hamochromatose und aplastischer anamie. Schweiz Med Wochenschr. 1970;100:303–305
  57. Stibler H, Borg S. Evidence of a reduced sialic acid content in serum transferrin in male alcoholics. Alcohol: Clin Exp Res. 1981;5:545–549
  58. Stibler H, Sydow O, Borg S. Quantitative estimation of abnormal microheterogeneity of serum transferrin in alcoholics. Pharmacol, Biochem Behav. 1980;13(Suppl. 1):47–51
  59. Tsukamoto H, Horne W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest. 1995;96:620–630
  60. Volentine GD, Tuma DJ, Sorrell MF. Acute effects of ethanol on hepatic glycoprotein secretion in the rat in vivo. Gastroenterology. 1984;86:225–229
  61. Ward C, Saltman P, Ripley L, Ostrup R, Hegenauer J, Hatlen L, et al. Correlation of serum ferritin and liver ferritin iron in the anemic, normal, iron-loaded rat. Am J Clin Nutr. 1977;30:1054–1063
  62. Zhang H, Loney LA, Potter BJ. Effect of chronic alcohol feeding on hepatic iron status and ferritin uptake by rat hepatocytes. Alcohol: Clin Exp Res. 1993;17:394–400
  63. Zhang H, Potter BJ. The effect of ethanol metabolism on ferritin uptake by freshly isolated rat hepatocytes: is acetaldehyde responsible for this alteration?. Alcohol: Clin Exp Res. 1992;16:301–307
  64. Zuyderhoudt FM, Sindram JW, Marx JJ, Jorning GG, van Gool J. The amount of ferritin and hemosiderin in the livers of patients with iron-loading diseases. Hepatology. 1983;3:232–235

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Alcohol
Volume 23, Issue 2 , Pages 71-81 , February 2001

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