Alcohol
Volume 23, Issue 2 , Pages 83-90 , February 2001

Extracellular magnesium regulates nuclear and perinuclear free ionized calcium in cerebral vascular smooth muscle cells: possible relation to alcohol and central nervous system injury

  • Burton M Altura

      Affiliations

    • Department of Physiology, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA
    • Department of Medicine, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA
    • The Center for Cardiovascular and Muscle Research, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA
    • Corresponding Author InformationCorresponding author. SUNY Health Science Center, Box 31, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. Tel.: +1-718-270-2194; fax: +1-718-270-3103
  • ,
  • Aimin Zhang

      Affiliations

    • Department of Physiology, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA
  • ,
  • Toni P.O Cheng

      Affiliations

    • Department of Anatomy Cell Biology, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA
  • ,
  • Bella T Altura

      Affiliations

    • Department of Physiology, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA
    • The Center for Cardiovascular and Muscle Research, Health Science Center, State University of New York at Brooklyn, Brooklyn, NY 11203, USA

Received 5 April 1999 ,Revised 5 October 2000 ,Accepted 6 October 2000.

References 

  1. Altura BM, Altura BT. Magnesium and contraction of arterial smooth muscle. Microvasc Res. 1974;7:145–155
  2. Altura BM, Altura BT. New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system: II. Experimental aspects. Magnesium. 1985;4:245–271
  3. Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol: Clin Exp Res. 1994;18:1057–1068
  4. Altura BM, Altura BT. Magnesium and cardiovascular biology: an important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res. 1995;41:347–359
  5. Altura BM, Altura BT. Magnesium in cardiovascular biology. Sci Am Sci Med. 1995;2(3):28–37
  6. Altura BM, Altura BT. Role of magnesium in the pathogenesis of hypertension updated: relationship to its action on cardiac, vascular smooth muscle and endothelial cells. In:  Laragh JH,  Brenner BM editor. Hypertension: Pathophysiology, Diagnosis, and Management. 2nd ed.. New York: Raven Press; 1995;p. 1213–1242
  7. Altura BM, Altura BT. Magnesium as an extracellular signal in cardiovascular pathobiology. J Jpn Soc Magnesium Res. 1996;15:17–32
  8. Altura BM, Altura BT, Carella A, Gebrewold A, Murakawa T, Nishio A. Mg2+–Ca2+ interaction in contractility of vascular smooth muscle: Mg2+ versus organic calcium channel blockers on myogenic tone and agonist-induced responsiveness of blood vessels. Can J Physiol Pharmacol. 1987;65:729–745
  9. Altura BM, Altura BT, Carella A, Turlapaty PD. Ca2+ coupling in vascular smooth muscle: Mg2+ and buffer effects on contractility and membrane Ca2+ movements. Can J Physiol Pharmacol. 1982;60:459–482
  10. Altura BM, Altura BT, Gebrewold A. Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death. Science. 1983;220:331–333
  11. Altura BM, Altura BT, Gebrewold A, Ising H, Günther T. Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ. Science. 1984;223:1315–1317
  12. Altura BM, Altura BT, Gebrewold A, Ising H, Günther T. Noise-induced hypertension and magnesium in rats: relationship to microcirculation and calcium. J Appl Physiol. 1992;72:194–202
  13. Altura BM, Gebrewold A. α-Tocopherol attenuates alcohol-induced cerebral vascular damage: possible role of oxidants in alcohol brain pathology and strokes. Neurosci Lett. 1996;220:207–210
  14. Altura BM, Gebrewold A. Pyrollidine dithiocarbamate attenuates alcohol-induced leukocyte–endothelial cell interaction and cerebral vascular damage in rats: possible role of activation of transcription factor NF-κB in alcohol brain pathology. Alcohol. 1998;16:25–28
  15. Altura BM, Gebrewold A, Altura BT, Gupta RK. Role of brain [Mg2+]i in alcohol-induced hemorrhagic stroke in a rat model: a 31P-NMR in vivo study. Alcohol. 1995;12:131–136
  16. Altura BM, Gebrewold A, Altura BT, Gupta RK. Magnesium protects against cocaine-induced hemorrhagic stroke in a rat model: a 31P-NMR in-vivo study. Front Biosci. 1997;2:a9–a12
  17. Altura BM, Gebrewold A, Zhang A, Altura BT, Gupta RK. Magnesium deficiency exacerbates brain injury and stroke mortality induced by alcohol: a 31P-NMR in vivo study. Alcohol. 1998;15:181–183
  18. Altura BM, Gupta RK. Cocaine induces intracellular free Mg deficits, ischemia and stroke as observed by in-vivo 31P-NMR of the brain. Biochim Biophys Acta. 1992;1111:271–274
  19. Altura BM, Memon ZS, Altura BT, Cracco RQ. Alcohol-associated acute head trauma in human subjects is associated with early deficits in serum ionized Mg and Ca. Alcohol. 1995;12:433–437
  20. Altura BM, Zhang A, Altura BT. Exposure of piglet coronary arterial muscle cells to low concentrations of Mg2+ found in blood of ischemic heart disease patients result in rapid elevation of cytosolic Ca2+: relevance to sudden infant death syndrome. Eur J Pharmacol. 1997;338:R7–R9
  21. Altura BM, Zhang A, Cheng TP-O, Altura BT. Ethanol promotes rapid depletion of intracellular free Mg in cerebral vascular smooth muscle cells: possible relation to alcohol-induced behavioral and stroke-like effects. Alcohol. 1993;10:563–566
  22. Altura BM, Zhang A, Yang Z-W, Morrill GA, Gupta RK, Kostellow AB. Expression of NF-κB and proto-oncogenes, c-fos and c-Jun, are induced by low extracellular Mg2+ ([Mg2+]o) in aortic and cerebral vascular smooth muscle cells: links to atherogenesis. FASEB J. 2000;14:a460
  23. Altura BT, Altura BM. Withdrawal of magnesium causes vasospasm while elevated magnesium produces relaxation of tone in cerebral arteries. Neurosci Lett. 1980;20:323–327
  24. Altura BT, Altura BM. The role of magnesium in etiology of strokes and cerebrovasospasm. Magnesium. 1982;1:277–291
  25. Altura BT, Altura BM. Interactions of Mg and K on cerebral vessels — aspects in view of stroke. Review of present status and new findings. Magnesium. 1984;3:195–211
  26. Altura BT, Brust M, Bloom S, Barbour RL, Stempak JG, Altura BM. Magnesium dietary intake modulates blood lipid levels and atherogenesis. Proc Natl Acad Sci USA. 1990;87:1840–1844
  27. Altura BT, Memon ZI, Zhang A, Cheng TP-O, Silverman R, Cracco RQ, et al. Low levels of serum ionized magnesium are found in patients early after stroke which result in rapid elevation of cytosolic free calcium and spasm in cerebral vascular muscle cells. Neurosci Lett. 1997;230:37–40
  28. Altura BT, Shirey TL, Young CC, Hiti J, Dell'Orfano K, Handwerker SM, et al. A new method for the rapid determination of ionized Mg2+ in whole blood, serum and plasma. Methods Find Exp Clin Pharmacol. 1992;14:297–304
  29. Burnier M, Centeno G, Burki E, Brunner HR. Confocal microscopy to analyze cytosolic and nuclear calcium in cultured vascular cells. Am J Physiol. 1994;266:C1118–C1127
  30. Chamley-Campbell J, Campbell GR, Ross R. The smooth muscle cell in culture. Physiol Rev. 1979;59:1–61
  31. Choi DW. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 1988;11:465–469
  32. Dobi A, v. Agoston D. Submillimolar levels of calcium regulates DNA structure at the dinucleotide repeat (TG/AC)n. Proc Natl Acad Sci USA. 1998;95:5981–5986
  33. Ema M, Gebrewold A, Altura BT, Altura BM. Magnesium sulfate prevents alcohol-induced spasms of cerebral blood vessels: an in situ study on the brain microcirculation from male versus female rats. Magnesium Trace Elem. 1991;10:269–280
  34. Gillo B, Ma Y-S, Marks AR. Calcium influx in induced differentiation of murine erythroleukemia cells. Blood. 1993;81:783–792
  35. Ginty DD. Calcium regulation of gene expression: isn't that spatial?. Neuron. 1997;18:183–186
  36. Hardingham GE, Cruzalegui FH, Chawla S, Bading H. Mechanisms controlling gene expression by nuclear calcium signals. Cell Calcium. 1998;23:131–134
  37. Lenormand P, Muldoon LL, Enslen H, Rodland KD, Magun BE. Two tumor promoters, 12-0-tetradecanoylphorbol-13-acetate and thapsigargin, act synergistically via distinct signaling pathways to stimulate gene expression. Cell Growth Differ. 1990;1:627–635
  38. Li W, Zheng T, Wang J, Altura BT, Altura BM. Pyrrolidine dithiocarbamate prevents ethanol-induced elevation of [Ca2+]i in cultured canine cerebral vascular smooth muscle cells. Neurosci Lett. 1999;266:205–208
  39. Marinov MB, Harbaugh KS, Hoopes PJ, Pikus HJ, Harbaugh RE. Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia. J Neurosurg. 1996;85:117–124
  40. McIntosh TK, Vink R, Yamakami I, Faden AI. Magnesium protects against neurological deficit after brain injury. Brain Res. 1989;482:252–260
  41. Memon ZI, Altura BT, Benjamin JL, Cracco RQ, Altura BM. Predictive value of serum ionized but not total magnesium levels in head injuries. Scand J Clin Lab Invest. 1995;55:671–677
  42. Muir KW, Lees KR. A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. Stroke. 1995;26:1183–1188
  43. Nicotera P, Bellomo G, Orrenius S. The role of Ca2+ in cell killing. Chem Res Toxicol. 1990;3:484–494
  44. Rasmussen H. The calcium messenger system: I. N Engl J Med. 1986;314:1094–1101
  45. Rasmussen H. The calcium messenger system: II. N Engl J Med. 1986;314:1164–1170
  46. Rothman S, Olney JW. Glutamate and the pathophysiology of hypoxic–ischemic brain damage. Ann Neurol. 1986;19:105–111
  47. Sheng M, Thompson MA, Greenberg ME. CREB: a Ca2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science. 1991;252:1427–1430
  48. Sjögren A, Edvinsson L, Fallgren B. Magnesium deficiency in coronary artery disease and cardiac arrhythmias. J Int Med. 1989;226:213–222
  49. Turlapaty PD, Altura BM. Extracellular magnesium ions control calcium exchange and content of vascular smooth muscle. Eur J Pharmacol. 1978;52:421–423
  50. Villereal ML, Byron KL. Calcium signals in growth factor signal transduction. Rev Physiol, Biochem Pharmacol. 1992;119:67–121
  51. Vink R, McIntosh TK, Demediuk P, Weiner MW, Faden AI. Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma. J Biol Chem. 1988;263:757–761
  52. In:  Weiss GB editors. New Perspectives on Calcium Antagonists. Washington, DC: American Physiology; 1981;
  53. Zhang A, Cheng TP, Altura BM. Magnesium regulates intracellular free ionized calcium concentration and cell geometry in vascular smooth muscle cells. Biochim Biophys Acta. 1992;1134:25–29
  54. Zhang A, Fan SH, Cheng TP, Altura BT, Wong RK, Altura BM. Extracellular Mg2+ modulates intracellular Ca2+ in acutely isolated hippocampal CA1 pyramidal cells of the guinea pig. Brain Res. 1996;728:204–208

PII: S0741-8329(00)00131-2

Alcohol
Volume 23, Issue 2 , Pages 83-90 , February 2001