Alcohol
Volume 23, Issue 1 , Pages 35-39 , January 2001

Acetaldehyde in vitro exposure and apoptosis: a possible mechanism of teratogenesis

Received 2 February 2000 ,Revised 17 July 2000 ,Accepted 19 September 2000.

References 

  1. Abrams JM, White K, Fessler LI, Steller H. Programmed cell death during Drosophila embryogenesis. Development. 1993;117:29–43
  2. Alles AJ, Sulik KK. Retinoic acid induced limb reduction defects: perturbation of zones of programmed cell death as a pathogenetic mechanism. Teratology. 1989;40:163–171
  3. Alles AJ, Sulik KK. Retinoic acid-induced spina bifida: evidence for a pathogenetic mechanism. Development. 1990;108:73–81
  4. Brown NA, Fabro S. Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology. 1981;24:65–78
  5. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493–501
  6. Giavini E, Broccia ML, Prati M, Bellomo D, Menegola E. Effects of ethanol and acetaldehyde on rat embryos developing in vitro. In Vitro Cell Dev Biol. 1992;28A:205–210
  7. Jones KL, Smith DW, Ulleland CL, Sreissguth AP. Pattern of malformation in offspring of chronic alcoholic mothers. Lancet. 1973;1:1267–1271
  8. Knudsen TB, Winters RS, Otey SK, Blackburn MR, Airhart MJ, Church JK, et al. Effects of (R)-deoxycoformycin (pentostatin) on intrauterine nucleoside catabolism and embryo viability in the pregnant mouse. Teratology. 1992;45:91–103
  9. Kotch LE, Sulik KK. Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated craniofacial and brain anomalies. Am J Med Genet. 1992;44:168–176
  10. Lindros KO. Human blood acetaldehyde levels: with improved methods, a clear picture emerges. Alcohol Clin Exp Res. 1983;7:70–75
  11. Little SA, Mirkes PE. DNA cross-linking and single strand breaks induced by teratogenic by teratogenic concentrations of 4-hydroperoxycyclophosphamide and phosphoramide mustard in postimplantation rat embryos. Cancer Res. 1992;47:5421–5426
  12. McCafferey P, Lee M, Wagner MA, Sladek NE, Drager UC. Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina. Development. 1992;115:371–382
  13. McCafferey P, Tempst P, Lara G, Drager UC. Aldehyde dehydrogenase is a positional marker in the retina. Development. 1991;112:693–702
  14. Menegola E, Broccia ML, Prati M, Ricolfi R, Giavini E. Glutathione and N-acetylcysteine protection against acetaldehyde embryotoxicity in rat embryos developing in vitro. Toxic In Vitro. 1995;5:633–641
  15. Milligan CE, Schwartz L. Programmed cell death during animal development. Br Med Bull. 1997;52:570–590
  16. Mulvihill JJ. Fetal alcohol syndrome. Teratology. 1986;13:345–348
  17. O'Shea KS, Kaufman MK. The teratogenic effect of acetaldehyde: implications for the study of the fetal alcohol syndrome. J Anat. 1979;128:65–76
  18. Padmanabham R, Sreenatan RN, Singh S. Studies on lethal and teratogenic effects of acetaldehyde in the rat. Con Anom. 1983;23:13–23
  19. Peterson KP, Bowers C, Peterson CM. Prevalence of ethanol consumption may be higher in women than in man in a university health service population as determined by a biochemical marker: whole blood-associated acetaldehyde above the 99th percentile for teetotalers. J Addict Disord. 1998;17:13–23
  20. Sulik KK. Critical periods for alcohol teratogenic in mice, with special reference to the gastrulation stage of embrypogenesis. In: Ciba Foundation Symposium 105, Mechanisms of Alcohol Damage in Utero. London: Pitman; 1984;p. 124–141
  21. Sulik KK, Johnston MC, Daft PA, Russell WE, Dehart DB. Fetal alcohol syndrome and DiGeorge anomaly: critical ethanol exposure periods for craniofacial malformations as illustrated in an animal model. Am J Med Genet. 1986;2:97–112
  22. Sulik KK, Johnston MC, Webb MA. Fetal alcohol syndrome: embryogenesis in a mouse model. Science. 1981;214:936–938
  23. Thayer JM, Mirkes PE. Programmed cell death and N-acetoxy-2-acethylaminofluorene-induced apoptosis in the rat embryo. Teratology. 1995;51:18–29
  24. Vaux DL, Korsmeyer SJ. Cell death in development. Cell. 1999;96:245–254
  25. Vonesch J, Nakshatri H, Philippe M, Chambon P, Dolle P. Stage and tissue-specific expression of the alcohol dehydrogenase I (Adh-I) gene during mouse development. Dev Dyn. 1994;199:199–213
  26. Webster WS, Walsh DA, McEwen SE, Lipson AH. Some teratogenic properties of ethanol and acetaldehyde in C57Bl/6J mice; implications for the study of fetal alcohol syndrome. Teratology. 1983;27:231–243
  27. Zakeri ZF, Ahuja HS. Cell death/apoptosis: normal, chemically induced, and teratogenic effect. Mutat Res. 1997;396:149–161

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Alcohol
Volume 23, Issue 1 , Pages 35-39 , January 2001

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