Alcohol
Volume 23, Issue 1 , Pages 29-34 , January 2001

Serum cytokine levels in alcohol-related liver cirrhosis

  • Jadwiga Daniluk

      Affiliations

    • Clinic and Department of Gastroenterology, University Medical School, Jaczewskiego 8, 20-950 Lublin, Poland
    • ,
  • Agnieszka Szuster-Ciesielska

      Affiliations

    • Department of Virology and Immunology, Maria Curie-Skodowska University, Akademicka 19, 20-033 Lublin, Poland
    • ,
  • Jarosaw Drabko

      Affiliations

    • Division of Gastroenterology, District Hospital, Al.Kraśnicka 100, 20-718 Lublin, Poland
    • ,
  • Martyna Kandefer-Szerszeń

      Affiliations

    • Department of Virology and Immunology, Maria Curie-Skodowska University, Akademicka 19, 20-033 Lublin, Poland
    • Corresponding Author InformationCorresponding author. Fax: +48-81-537-59-59

Received 18 January 2000 ,Revised 9 May 2000 ,Accepted 18 September 2000.

References 

  1. Bird GLA, Sheron N, Goka AKJ, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med. 1990;112:917–920
  2. Bode C, Kugler V, Bode JC. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver diseases following acute alcohol excess. J Hepatol. 1987;4:8–14
  3. Castilla A, Prieto J, Fausto N. Transforming growth factor β1 and α in chronic liver disease. Effects of interferon alpha therapy. New Engl J Med. 1991;324:933–940
  4. Dashti HM, Abul H, Behbehani A, Hussain T, Madda JP. Interleukin-8 and trace element alterations in experimentally induced liver cirrhosis: the influence of zinc, selenium, and allopurinol treatment. J Trace Elem Exp Med. 1996;9:27–40
  5. Deviere J, Content J, Denys C, Vandenbussche P, Moine OL, Schandene L, et al. Immunoglobulin A and IL-6 forms a positive secretory feedback loop: a study of normal subjects and alcoholic cirrhotics. Gastroenterology. 1992;103:1296–1300
  6. Deviere J, Content J, Denys C, Vandenbussche P, Schandene L, Wybran J, et al. High interleukin-6 serum levels and increased production of by leukocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. Clin Exp Immunol. 1989;77:221–225
  7. Deviere J, Vaerman JP, Content J, Denys C, Schandene L, Vandenbussche P, et al. IgA triggers tumor necrosis factor-α secretion by monocytes: a study in normal subjects and patients with alcoholic cirrhosis. Hepatology. 1991;13:670–675
  8. DeWaal Malefyt R, Abrams J, Bennet B. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991;174:1209–1220
  9. Dubois CM, Ruscetti FW, Palaszynski EW. Transforming growth factor β is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action. J Exp Med. 1990;172:737–744
  10. Dunham DM, Arkins S, Edwards CK, Dantzer R, Kelley KW. Role of interferon-gamma in counteracting the suppressive effects of transforming growth factor-β2 and glucocorticoids on the production of tumor necrosis factor-α. J Leukoc Biol. 1990;48:473–481
  11. Felver ME, Mezey E, McGuire M, Mitchell MC, Herlong HF, Veech GA, et al. Plasma tumor necrosis factor-α predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res. 1990;14:255–259
  12. Hanck C, Glatzel M, Singer MV, Rossol S. Gene expression of TNF-receptors in peripheral blood mononuclear cells of patients with alcoholic cirrhosis. J Hepatol. 2000;32:51–57
  13. Hill DB, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ. Increased plasma interleukin-6 activity in alcoholic hepatitis. J Lab Clin Med. 1992;119:547–552
  14. Hill DB, Marsano LS, McClain CJ. Increased plasma interleukin-8 concentration in alcoholic hepatitis. Hepatology. 1993;18:576–580
  15. Hirsch S, Munoz C, delaMaza MP, Petermann M, Lopez M, Schlesinger L, et al. Increased cytokine production is associated with acute inflammation in cirrhotic alcoholic patients. Int Hepatol Commun. 1997;6:166–174
  16. Huang YS, Chan CY, Wu JC, Pai CH, Chao Y, Lee SD. Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. J Hepatol. 1996;24:377–384
  17. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology. 1991;13:267–276
  18. Laso FJ, Lapena P, Madruga JI, San Miguel JF, Orfao A, Iglesias MC, et al. Alterations in tumor necrosis factor-α, interferon-γ, and interleukin-6 production by natural killer cell-enriched peripheral blood mononuclear cells in chronic alcoholism: relationship with liver disease and alcohol intake. Alcohol Clin Exp Res. 1997;21:1226–1231
  19. Le Moine O, Marchant A, De Groote D, Azar C, Goldman M, Deviere J. Role of defective monocyte interleukin-10 release in tumor necrosis factor-α overproduction in alcoholics cirrhosis. Hepatology. 1995;22:1436–1439
  20. Louis H, VanLaethem JL, Wu W, Quertinmot E, Degraef C, Van den Berg K, et al. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology. 1998;28:1607–1615
  21. Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: implication for a role in alcoholic liver fibrogenesis. Hepatology. 1990;11:599–605
  22. Matsuoka M, Zhang MY, Tsukamoto H. Sensitization of hepatic lipocytes by high-fat diet to stimulatory effect of Kupffer cell-derived factors: implication in alcoholic liver fibrogenesis. Hepatology. 1990;11:173–185
  23. McClain CJ, Cohen DA, Dinarello CA, Cannon JG, Shedlofsky SI, Kaplan AM. Serum interleukin-1 (IL-1) activity in alcoholic hepatitis. Life Sci. 1986;39:1479–1485
  24. Okuno M, Moriwaki H, Imai S, Muto Y, Kawada N, Suzuki Y, et al. Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-β in liver stellate cells. Hepatology. 1997;26:913–921
  25. Sheron N, Bird G, Goka AKJ, Alexander GJ, Williams RS. Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis. Clin Exp Immunol. 1991;84:449–453
  26. Sheron N, Bird G, Koskinas J, Portmann B, Ceska M, Lindley I, et al. Circulating and tissue levels of neutrophil chemotaxin interleukin-8 are elevated in severe acute hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology. 1993;18:41–46
  27. Thompson K, Maltby J, Fallowfield J, McAulay M, Millward-Sadler H, Sheron N. Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis. Hepatology. 1998;28:1597–1606
  28. Tilg H, Wilmer A, Vogel W, Herold M, Nolchen B, Judmaier G, et al. Serum level of cytokines in chronic liver diseases. Gastroenterology. 1992;103:264–274
  29. Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem. 1998;273:302–308

PII: S0741-8329(00)00134-8

Alcohol
Volume 23, Issue 1 , Pages 29-34 , January 2001

Article Tools

* Image Usage & Resolution