Alcohol
Volume 23, Issue 1 , Pages 23-28 , January 2001

The pharmacodynamics of anticonvulsant and subconvulsant effects of ethanol in CBA and C57BL/6 mice

Received 4 February 1999 ,Revised 18 May 2000 ,Accepted 24 August 2000.

References 

  1. Aguayo LG, Pancetti FC. Ethanol modulation of gamma-aminobutyric acid A- and glycine-activated Cl− current in cultured mouse neurons. J Pharmacol Exp Ther. 1994;270(1):61–69
  2. Airaksinen MM, Peura P. Mechanism of alcohol withdrawal syndrome. Med Biol. 1987;65:105–112
  3. Burk KJ, Harris RA. Benzodiazepine agonist and inverse agonist action on GABAA receptor-operated chloride channels: 1. Acute effect of ethanol. J Pharmacol Exp Ther. 1990;253:706–719
  4. Burov YuV, Vedernikov NN. Neurochemistry and pharmacology of alcoholism. Moscow: Medicine; 1985;
  5. Chwen AJ, Ullogue AA, Swinywid EA, Wola HH. Effects of picrotoxinin on benzodiazepine receptor binding. Neurochem Res. 1985;10:871–877
  6. Crabbe JC, Belknap JK, Buck KL. Genetic animal models of alcohol and drug abuse. Science. 1994;264(5166):1715–1723
  7. Crabbe JC, Belknap JK, Buck RL, Metten P. Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Alcohol Alcohol. 1994;suppl. 2:67–71
  8. Croff M, Willams P, Preiffer C. Timed intravenous infusion of metrasol and strychnine for testing anticonvulsant drugs. Proc Soc Exp Biol. 1949;70:254–258
  9. Draski LI, Spuhler KP, Erwing VG, Deitrich RA. Selective breeding of rat differing in sensitivity to the effects of acute ethanol administration. Alcohol Clin Exp Res. 1992;16(1):48–54
  10. Fadda F, Mosca E, Colombo G, Gessa GL. Gamma-hydroxybutyric acid suppresses ethanol consumption in alcohol-preferring rats. Psychopharmacol. 1988;96(suppl.):107–108
  11. Faingold CL, N'Gouemo P, Riaz A. Ethanol and neurotransmitter interactions — from molecular to integrative effects. Prog Neurobiol. 1998;55:509–535
  12. Freund RK, van Home CG, Harlan T, Palmer MR. Electrophysiological interaction of ethanol with GABAergic mechanisms in the rat cerebellum in vivo. Alcohol Clin Exp Res. 1993;17(2):321–328
  13. Glowa JR, Crawley J, Suzdak PD, Paul SM. Ethanol and the GABA receptor complex: studies with partial inverse benzodiazepine receptor agonist Ro l5-4513. Pharmacol Biochem Behav. 1988;31:767–772
  14. Golovenko NYa, Zinkovsky VG, Zhuk OV, Stankevich EA, Fedorova EA, Vasilinin GB. Optimising GABA-RC inverse agonists infusion method in analysis of rapidly reversed effects of tranquilizers and ethanol. Bull Exp Biol Med. 1997;123(5):551–554
  15. Greenberg DA, Cooper EG, Gordon A, Diamond L. Ethanol and the γ-aminobutiric acid–benzodiazepine receptor complex. J Neurochem. 1984;42:1062–1068
  16. Harris RA, Allan AM. Genetic differences in coupling of benzodiazepine receptors to chloride channels. Brain Res. 1989;490(1):26–32
  17. Harris RA, Mihic SJ, Brozowski S, Hadingham K, Whiting PJ. Ethanol, flunitrazepam, and pentobarbital modulation of GABAA receptor expressed in mammalian cells and Xenopus oocytes. Alcohol Clin Exp Res. 1997;21:444–451
  18. Harris RA, Valenzuela CF, Brozowski S, Chuang L, Hadingham K, Whiting PJ. Adaptation of γ-aminobutyric acid type A receptors to alcohol exposure: studies with stable transfected cells. J Pharmacol Exp Ther. 1998;284:180–188
  19. Hellevuo K, Kiianmaa K, Korpi ER. Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol. Pharmacol Biochem Behav. 1989;34:399–404
  20. Kohlenberg-Muller K, Bitsch I. Neue Methoden zur pharmalcokinetischen Beschreibung des Alkohols und seiner Metaboliten bei weiblichen und manniichen Versuchspersonen. Blutalkohol. 1989;26:396–399
  21. Kopri ER, Makela R, Uusi-Oukari M. Ethanol: novel actions on nerve cell physiology explain impaired functions. News Physiol Sci. 1998;13:164–170
  22. Kosobud AE, Cross SJ, Crabbe JC. Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice. Brain Res. 1992;592(1–2):122–128
  23. Lister RG, Durcan MJ. Antagonism of the intoxicating effects of ethanol by the potent benzodiazepine receptor ligand Ro 19-4603. Brain Res. 1989;1:141–144
  24. Mahmoud MIE, Potter JJ, Golvin OM, Hilton J, Mezey E. Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice. Alcohol Clin Exp Res. 1993;17(6):1223–1227
  25. Menta AK, Ticku MK. Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves γ-aminobutyric acid-gated chloride channels. J Pharmacol Exp Ther. 1988;246:558–564
  26. Mihic SJ. Acute effect of ethanol on GABAA and glycine receptor function. Neurochem Int. 1999;35:115–123
  27. Miller LG, Greenblat DJ, Barnhill JG, Shader RI. Differential modulation of benzodiazepine receptor binding by ethanol in LS and SS mice. Pharmacol Biochem Behav. 1988;29:471–477
  28. Nakahiro M, Arakawa O, Narahashi T, Nishimura T. GABA receptor–chloride channel complex as target site of alcohol. In:  Tanaka C,  Bowery NG editor. GABA: receptor, transporters and metabolism. Berlin: Basti-Bjston; 1996;p. 221–226
  29. Nutt DL, Littli HI, Taylor SC, Winohin MCW. Investigating benzodiazepine receptor function in vivo using an intravenous infusion of DMCM. Eur J Pharmacol. 1984;103:359–362
  30. Phillips TJ, Dudek BC. Modification of ethanol effects by bicuculline: genotype-dependent responses and inheritance. Psychopharmacology (Berlin). 1989;98(4):549–555
  31. Reynolds JN, Prasad A. Ethanol enhances GABA receptor-activated chloride currents in chick cerebral cortical neurons. Brain Res. 1991;564:138–142
  32. San-Marina A, Khanna JM, Kalant H. Relationship between initial sensitivity, acute tolerance and chronic tolerance to ethanol in heterogeneous population of Swiss mice. Psychopharmacol. 1989;99:450–457
  33. Suzdak PD, Schwartz RD, Skolnick P, Paul SM. Ethanol stimulates γ-aminobutiric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci USA. 1986;83:4071–4075
  34. Tatebayashi H, Motomura H, Narahashi T. Alcohol modulation of single GABAA receptor–channel kinetic. Neuropharmacology. 1998;9:1769–1775
  35. Thompson EB. Drug bioscreening: drug evaluation techniques in pharmacology. 1990;New York: Weinheim, Basel, Cambridge
  36. Vlasova NP, Rodionov AP. The pharmacokinetics of ethanol in animals and alcohol preference. In:  Valdman AB editors. Experimental and clinical pharmacokinetics. Moscow: Medicine; 1988;p. 118–123
  37. Zheng YW, Felder MR. Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex. Biochem Genet. 1997;35(3–4):105–117

PII: S0741-8329(00)00136-1

Alcohol
Volume 23, Issue 1 , Pages 23-28 , January 2001

Article Tools

* Image Usage & Resolution