Alcohol
Volume 23, Issue 2 , Pages 109-116 , February 2001

Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption

  • Michael F Stromberg

      Affiliations

    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
    • Corresponding Author InformationCorresponding author. Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA. Tel.: +1-215-823-4325; fax: +1-215-823-5171
  • ,
  • Scott A Mackler

      Affiliations

    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
    • Department of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
  • ,
  • Joseph R Volpicelli

      Affiliations

    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
  • ,
  • Charles P O'Brien

      Affiliations

    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA

Received 7 April 2000 ,Revised 26 October 2000 ,Accepted 2 November 2000.

References 

  1. al Qatari M, Bouchenafa O, Littleton J. Mechanism of action of acamprosate: Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res. 1998;22:810–814
  2. Benjamin D, Grant ER, Pohorecky LA. Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. Brain Res. 1993;621:137–140
  3. Berton F, Francesconi WG, Madamba SG, Zieglgansberger W, Siggins GR. Acamprosate enhances N-methyl-d-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin Exp Res. 1998;22:183–191
  4. Cole JC, Littleton JM, Little HJ. Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology (Berlin). 2000;147:403–411
  5. Dahchour A, De Witte P, Bolo N, Nedelec JF, Muzet M, Durbin P, et al. Central effects of acamprosate: Part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats. Psychiatry Res. 1998;82:107–114
  6. Diana M, Pistis M, Carboni S, Gessa GL, Rossetti ZL. Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence. Proc Natl Acad Sci USA. 1993;90:7966–7969
  7. Gallant G. Alcohol. In:  Galanter M,  Kleber HD editor. The American Psychiatric Press Textbook of Substance Abuse Treatment. Washington, DC: American Psychiatric Press; 1994;p. 69–71
  8. Gonzales RA, Weiss F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in nucleus accumbens. J Neurosci. 1998;18:10663–10671
  9. Grant KA, Valverius P, Hudspith M, Tabakoff B. Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol. 1990;176:289–296
  10. Gulya K, Grant KA, Valverius P, Hoffman PL, Tabakoff B. Brain regional specificity and time-course of changes in the NMDA receptor–ionophore complex during ethanol withdrawal. Brain Res. 1991;547:129–134
  11. Heyser CJ, Schulteis G, Durbin P, Koob GF. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology. 1998;18:125–133
  12. Heyser CJ, Schulteis G, Koob GF. Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res. 1997;21:784–791
  13. Hoffman PL, Rabe CS, Grant KA, Valverius P, Hudspith M, Tabakoff B. Ethanol and the NMDA receptor. Alcohol. 1990;7:229–231
  14. Hoffman PL, Rabe CS, Moses F, Tabakoff B. N-methyl-d-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neurochem. 1989;52:1937–1940
  15. Holter SM, Landgraf R, Zieglgansberger W, Spanagel R. Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcohol Clin Exp Res. 1997;21:862–868
  16. Hu G, Duffy P, Swanson C, Ghasemzadeh MB, Kalivas PW. The regulation of dopamine transmission by metabotropic glutamate receptors. J Pharmacol Exp Ther. 1999;289:412–416
  17. Hubbell CL, Reid LD. Opioids modulate rats' intake of alcoholic beverages. In:  Reid LD editors. Opioids, Bulimia, and Alcohol Abuse and Alcoholism. New York: Springer-Verlag; 1990;p. 145–174
  18. Koob GF. Neural mechanisms of drug reinforcement. In:  Kalivas PW,  Samson HH editor. The Neurobiology of Drug and Alcohol Addiction. New York: New York Academy of Sciences; 1992;p. 171
  19. Legault M, Wise RA. Injections of N-methyl-d-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens. Synapse. 1999;31:241–249
  20. Le Magnen J, Tran G, Durlach J, Martin C. Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol. 1987;4:97–102
  21. Littleton J. Acamprosate in alcohol dependence: how does it work?. Addiction. 1995;90:1179–1188
  22. Maccecchini M-L. Development of ACPC, a partial agonist of the glycine site on the NMDA receptor. In:  Herrling PL editors. Excitatory Amino Acids: Clinical Results with Antagonists. San Diego: Academic Press; 1997;p. 43–55
  23. Macdonall JS, Marcucella H. Increasing the rate of ethanol consumption in food- and water-satiated rats. Pharmacol Biochem Behav. 1979;10:211–216
  24. Naassila M, Legrand E, d'Alche-Biree F, Daoust M. Cyamemazine decreases ethanol intake in rats and convulsions during ethanol withdrawal syndrome in mice. Psychopharmacology (Berlin). 1998;140:421–428
  25. Nie Z, Madamba SG, Siggins GR. Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J Pharmacol Exp Ther. 1994;271:1566–1573
  26. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatry. 1992;49:881–887
  27. Rassnick S, D'Amico E, Riley E, Pulvirenti L, Zieglgansberger W, Koob GF. GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in rats. In:  Kalivas PW,  Samson HH editor. The Neurobiology of Drug and Alcohol Addiction. New York: New York Academy of Sciences; 1992;p. 502–505
  28. Sass H, Soyka M, Mann K, Zieglgansberger W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry. 1996;53:673–680
  29. Schulteis G, Markou A, Cole M, Koob GF. Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci USA. 1995;92:5880–5884
  30. Selim M, Bradberry CW. Effect of ethanol on extracellular 5-HT and glutamate in the nucleus accumbens and prefrontal cortex: comparison between the Lewis and Fischer 344 rat strains. Brain Res. 1996;716:157–164
  31. Sesack SR, Pickel VM. Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J Comp Neurol. 1992;320:145–160
  32. Spanagel R, Holter SM, Allingham K, Landgraf R, Zieglgansberger W. Acamprosate and alcohol I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol. 1996;305:39–44
  33. Spanagel R, Putzke J, Stefferl A, Schobitz B, Zieglgansberger W. Acamprosate and alcohol: II. Effects on alcohol withdrawal in the rat. Eur J Pharmacol. 1996;305:45–50
  34. Spanagel R, Zieglgansberger W. Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci. 1997;18:54–59
  35. Stromberg MF, Casale M, Volpicelli L, Volpicelli JR, O'Brien CP. A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. Alcohol. 1998;15:281–289
  36. Stromberg MF, Volpicelli JR, O'Brien CP. Effects of naltrexone administered repeatedly across 30 or 60 days on ethanol consumption using a limited access procedure in the rat. Alcohol Clin Exp Res. 1998;22:2186–2191
  37. Stromberg MF, Volpicelli JR, O'Brien CP, Mackler SA. The NMDA receptor partial agonist, 1-aminocyclopropanecarboxylic acid (ACPC), reduces ethanol consumption in the rat. Pharmacol Biochem Behav. 1999;64:585–590
  38. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry. 1992;49:876–880
  39. Volpicelli JR, O'Brien CP, Alterman AI, Hayshida M. Naltrexone and the treatment of alcohol dependence: initial observations. In:  Reid LD editors. Opioids, Bulimia, and Alcohol Abuse and Alcoholism. New York: Springer-Verlag; 1990;p. 195–214
  40. Volpicelli JR, Rhines KC, Rhines JS, Volpicelli LA, Alterman AI, O'Brien CP. Naltrexone and alcohol dependence. Role of subject compliance. Arch Gen Psychiatry. 1997;54:737–742
  41. Volpicelli JR, Watson NT, King AC, Sherman CE, O'Brien CP. Effect of naltrexone on alcohol “high” in alcoholics. Am J Psychiatry. 1995;152:613–615
  42. Walaas I. Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain. Neuroscience. 1981;6:399–405

PII: S0741-8329(00)00137-3

Alcohol
Volume 23, Issue 2 , Pages 109-116 , February 2001