Alcohol
Volume 23, Issue 2 , Pages 123-126 , February 2001

Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats

  • Roberta Agabio

      Affiliations

    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09124 Cagliari, Italy
    • ,
  • Mauro A.M. Carai

      Affiliations

    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09124 Cagliari, Italy
    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • ,
  • Carla Lobina

      Affiliations

    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09124 Cagliari, Italy
    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • ,
  • Marialaura Pani

      Affiliations

    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09124 Cagliari, Italy
    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • ,
  • Roberta Reali

      Affiliations

    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • ,
  • Giovanni Vacca

      Affiliations

    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09124 Cagliari, Italy
    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • ,
  • Gian Luigi Gessa

      Affiliations

    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09124 Cagliari, Italy
    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • C.N.R. Center for Neuropharmacology, c/o “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, Via Porcell 4, I-09124 Cagliari, Italy
    • ,
  • Giancarlo Colombo

      Affiliations

    • C.N.R. Center for Neuropharmacology, c/o “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, Via Porcell 4, I-09124 Cagliari, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-70-675-8422; fax: +39-70-657-237

Received 9 March 2000 ,Revised 15 November 2000 ,Accepted 19 November 2000.

References 

  1. Carlsson A, Engel J, Svensson TH. Inhibition of ethanol-induced excitation in mice and rats by a α-methyl-p-tyrosine. Psychopharmacologia (Berlin). 1972;26:307–312
  2. Colombo G. Ethanol drinking behaviour in Sardinian alcohol-preferring rats. Alcohol Alcohol. 1997;32:443–453
  3. Colombo G, Agabio R, Lobina C, Reali R, Vacca G, Gessa GL. Stimulation of locomotor activity by voluntarily consumed ethanol in Sardinian alcohol-preferring rats. Eur J Pharmacol. 1998;357:109–113
  4. Colombo G, Agabio R, Lobina C, Reali R, Zocchi A, Fadda F, et al. Sardinian alcohol-preferring rats: a genetic animal model of anxiety. Physiol Behav. 1995;57:1181–1185
  5. Crabbe JC, Li T-K. Genetic strategies in preclinical substance abuse research. In:  Bloom FE,  Kupfer DJ editor. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press; 1995;p. 799–811
  6. Criswell HE, Overstreet DH, Rezvani AH, Johnson KB, Simson PE, Knapp DJ, et al. Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference. Alcohol: Clin Exp Res. 1994;18:917–923
  7. Imperato A, Di Chiara G. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther. 1986;239:219–228
  8. Kelley AE. Locomotor activity and exploration. In:  Sahgal A editors. Behavioural Neuroscience: A Practical Approach. Vol. II:Oxford: Oxford Univ. Press; 1993;p. 1–21
  9. Krimmer EC, Schechter MD. HAD and LAD rats respond differently to stimulating effect but not discriminative effects of ethanol. Alcohol. 1991;9:71–74
  10. Moore TO, June HL, Lewis MJ. Ethanol-induced stimulation and depression on measures of locomotor activity: effects of basal activity levels in rats. Alcohol. 1993;10:537–540
  11. Päivärinta P, Korpi ER. Voluntary ethanol drinking increases locomotor activity in alcohol-preferring AA rats. Pharmacol, Biochem Behav. 1993;44:127–132
  12. Quintanilla ME. Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats. Addict Biol. 1999;4:443–448
  13. Read GW, Cutting W, Furst A. Comparison of excited phases after sedatives and tranquilizers. Psychopharmacologia (Berlin). 1960;1:346–350
  14. Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., & Weiss, F. (in press). Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol preferring rats — a microdialysis and behavioral study. Alcohol: Clin Exp Res.
  15. Waller MB, Murphy JM, McBride WJ, Lumeng L, Li T-K. Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and-nonpreferring lines of rats. Pharmacol, Biochem Behav. 1986;24:617–623
  16. Wise RA, Bozarth MA. A psychomotor stimulant theory of addiction. Psychol Rev. 1987;94:469–492

PII: S0741-8329(00)00144-0

Alcohol
Volume 23, Issue 2 , Pages 123-126 , February 2001

Article Tools

* Image Usage & Resolution