Alcohol
Volume 23, Issue 3 , Pages 177-182 , April 2001

Differences in sensitivity to the aversive effects of ethanol in low-alcohol drinking (UChA) and high-alcohol drinking (UChB) rats

Received 21 July 2000 ,Revised 24 November 2000 ,Accepted 19 January 2001.

References 

  1. Eriksson CJ, Sippel HW, Forsander OA. The determination of acetaldehyde in biological samples by head-space gas chromatography. Anal Biochem. 1977;80:116–124
  2. Eriksson K. Genetic selection for voluntary alcohol consumption in the albino rat. Science. 1968;159:739–741
  3. Froehlich JC. Genetic factors in alcohol self-administration. J Clin Psychiatry. 1995;56(suppl 7):15–23
  4. Froehlich JC, Badia-Elder NE, Zinc RW, McCullough DE, Portoghese PS. Contribution of the opioid system to alcohol aversion and alcohol drinking behavior. J Pharmacol Exp Ther. 1998;287:284–292
  5. Froehlich JC, Harts J, Lumeng L, Li T-K. Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference. Pharmacol Biochem Behav. 1988;31:215–222
  6. Froehlich JC, Wand GS. Adenylyl cyclase signal transduction and alcohol-induced sedation. Pharmacol Biochem Behav. 1997;58:1021–1030
  7. Gill K, Deitrich RA. Acute tolerance to the ataxic effects of ethanol in short-sleep (SS) and long-sleep (LS) mice. Psychopharmacology (Berl). 1998;136:91–98
  8. Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC. Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav. 1998;59:627–635
  9. Le AD, Kiianmaa K. Role of initial sensitivity and genetic factors in the development of tolerance to ethanol in AT and ANT rats. Psychopharmacology (Berl). 1990;102:11–16
  10. Li T-K, Lumeng L. Alcohol metabolism of inbred strains of rats with alcohol preference and nonpreference. In:  Thurman RJ,  Williamson JR,  Droft HR,  Chance B editor. Alcohol and Aldehyde Metabolizing Systems. Intermediary Metabolism and Neurochemistry. Vol 3:New York: Academic Press; 1977;p. 625–633
  11. Linakis JG, Cunningham CL. Effects of concentration of ethanol injected intraperitoneally on taste aversion, body temperature, and activity. Psychopharmacology (Berl). 1979;64:61–65
  12. Mardones J, Segovia-Riquelme N. Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav Toxicol Teratol. 1983;5:171–178
  13. Murphy JM, Gatto GJ, McBride WJ, Lumeng L, Li T-K. Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. Alcohol. 1989;6:127–131
  14. Pohorecky LA. Biphasic action of ethanol. Biobehav Rev. 1977;1:231–240
  15. Quintanilla ME. Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats. Addict Biol. 1999;4:443–448
  16. Quintanilla ME, Sepúlveda S, Tampier L. Effect of diet and disulfiram on acetaldehyde blood levels after ethanol in UChA and UChB rats. Alcohol. 1993;10:381–385
  17. Risinger FO, Cunningham CL. Ethanol produces rapid biphasic hedonic effects. Ann NY Acad Sci. 1992;654:506–508
  18. Risinger FO, Cunningham CL. Genetic differences in ethanol-induced hyperglycemia and conditioned taste aversion. Life Sci. 1992;50:PL113–PL118
  19. Tampier L, Mardones J. Differences in ethanol sensitivity and acute tolerance between UChA and UChB rats. J Stud Alcohol. 1999;60:168–171
  20. Waller MB, McBride WJ, Gatto GJ, Lumeng L, Li T-K. Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. Science. 1984;225:78–80

 Editor: T.R. Jerrells

PII: S0741-8329(01)00128-8

Alcohol
Volume 23, Issue 3 , Pages 177-182 , April 2001