Alcohol
Volume 23, Issue 3 , Pages 183-188 , April 2001

Effect of prenatal and postnatal ethanol exposure on Ca2+/calmodulin-dependent protein kinase II in rat cerebral cortex

  • Kalyankar Mahadev

      Affiliations

    • School of Life Sciences, University of Hyderabad, Hyderabad-500 046, India
  • ,
  • Chellu S Chetty

      Affiliations

    • Department of Biology, Savannah State University, Savannah, GA 31404, USA
  • ,
  • Mohan C Vemuri

      Affiliations

    • School of Life Sciences, University of Hyderabad, Hyderabad-500 046, India
    • Corresponding Author InformationCorresponding author. Department of Anatomy, Cell Biology and Pathology, Thomas Jefferson University, Room No. 511, Building JAH, Philadelphia, PA 19107, USA. Tel.: +1-215-503-7837; fax: +1-215-923-3808

Received 15 May 2000 ,Revised 9 January 2001 ,Accepted 26 January 2001.

References 

  1. Ahmad Z, DePaoli-Roach AA, Roach PJ. Purification and characterization of a rabbit liver calmodulin-dependent protein kinase able to phosphorylate glycogen synthase. J Biol Chem. 1982;257:8348–8355
  2. Babu PP, Kumari LR, Vemuri MC. Differential changes in cell morphology, macromolecular composition and membrane protein profiles of neurons and astrocytes in chronic ethanol treated rats. Mol Cell Biochem. 1994;130:29–40
  3. Babu PP, Vemuri MC. Liver plasma membrane proteins in chronic ethanol intoxication. Biochem Int. 1990;20:573–577
  4. Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M. Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell. 1995;81:905–915
  5. Bading H, Ginty DD, Greenberg ME. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science. 1993;260:181–186
  6. Barria A, Muller D, Derkach V, Griffith LC, Soderling TR. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science. 1997;276:2042–2045see comments
  7. Bennett MK, Erondu NE, Kennedy MB. Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain. J Biol Chem. 1983;258:12735–12744
  8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254
  9. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci. 1990;13:171–182
  10. Colbran RJ, Schworer CM, Hashimoto Y, Fong YL, Rich DP, Smith MK, et al. Calcium/calmodulin-dependent protein kinase II. Biochem J. 1989;258:313–325
  11. Daniell LC, Brass EP, Harris RA. Effect of ethanol on intracellular ionized calcium concentrations in synaptosomes and hepatocytes. Mol Pharmacol. 1987;32:831–837
  12. De Koninck P, Schulman H. Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science. 1998;279:227–230see comments
  13. DePetrillo PB. Calcium-activated neutral protease activity is decreased in PC12 cells after ethanol exposure. J Neurochem. 1997;68:1863–1869
  14. Diamond I, Gordon AS. Cellular and molecular neuroscience of alcoholism. Physiol Rev. 1997;77:1–20
  15. Diaz-Granados JL, Spuhler-Phillips K, Lilliquist MW, Amsel A, Leslie SW. Effects of prenatal and early postnatal ethanol exposure on [3H] MK-801 binding in rat cortex and hippocampus. Alcohol Clin Exp Res. 1997;21:874–881
  16. Fuchs V, Coper H, Rommelspacher H. The effect of ethanol and haloperidol on dopamine receptor (D2) density. Neuropharmacology. 1987;26:1231–1233
  17. Fukunaga K, Rich DP, Soderling TR. Generation of the Ca2(+)-independent form of Ca2+/calmodulin-dependent protein kinase II in cerebellar granule cells. J Biol Chem. 1989;264:21830–21836
  18. Greengard P, Valtorta F, Czernik AJ, Benfenati F. Synaptic vesicle phosphoproteins and regulation of synaptic function. Science. 1993;259:780–785
  19. Haviryaji KS, Srinivas R, Suryanarayana T, Vemuri MC. Effect of ethanol on hepatic ribosomal proteins and mRNA. Mol Cell Biochem. 1992;115:143–147
  20. Haviryaji KS, Vemuri MC. Effect of ethanol on nuclear casein kinase II activity in brain. Neurochem Res. 1997;22:699–704
  21. Ishida A, Kameshita I, Okuno S, Kitani T, Fujisawa H. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995;212:806–812
  22. Kelly PT, Vernon P. Changes in the subcellular distribution of calmodulin-kinase II during brain development. Brain Res. 1985;350:211–224
  23. Kitamura Y, Miyazaki A, Yamanaka Y, Nomura Y. Stimulatory effects of protein kinase C and calmodulin kinase II on N-methyl-d-aspartate receptor/channels in the postsynaptic density of rat brain. J Neurochem. 1993;61:100–109
  24. Koch OR, De Leo ME, Borrello S, Palombini G, Galeotti T. Ethanol treatment up-regulates the expression of mitochondrial manganese superoxide dismutase in rat liver. Biochem Biophys Res Commun. 1994;201:1356–1365
  25. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–685
  26. Lai Y, Nairn AC, Greengard P. Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II. Proc Natl Acad Sci USA. 1986;83:4253–4257
  27. Leonard AS, Lim IA, Hemsworth DE, Horne MC, Hell JW. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-d-aspartate receptor. Proc Natl Acad Sci USA. 1999;96:3239–3244
  28. Mahadev K, Vemuri MC. Effect of ethanol on chromatin and nonhistone nuclear proteins in rat brain. Neurochem Res. 1998;23:1179–1184
  29. Mahadev K, Vemuri MC. Ethanol-induced changes in hepatic chromatin and nonhistone nuclear protein composition in the rat. Alcohol. 1998;15:207–211
  30. Mahadev K, Vemuri MC. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Arch Biochem Biophys. 1998;356:249–257
  31. Malenka RC, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, et al. An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature. 1989;340:554–557
  32. Malinow R, Schulman H, Tsien RW. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science. 1989;245:862–866
  33. McGlade-McCulloh E, Yamamoto H, Tan SE, Brickey DA, Soderling TR. Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II. Nature. 1993;362:640–642
  34. Messing RO, Petersen PJ, Henrich CJ. Chronic ethanol exposure increases levels of protein kinase δ and ε and protein kinase C–mediated phosphorylation in cultured neural cells. J Biol Chem. 1991;266:23428–23432
  35. Miller SG, Kennedy MB. Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch. Cell. 1986;44:861–870
  36. Miller SG, Patton BL, Kennedy MB. Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2(+)-independent activity. Neuron. 1988;1:593–604
  37. Nairn AC, Hemmings HC, Greengard P. Protein kinases in the brain. Annu Rev Biochem. 1985;54:931–976
  38. Samson HH, Diaz J. Effects of neonatal ethanol exposure on brain development in rodents. In:  Abel EL editors. Fetal Alcohol Syndrome. v. III:Boca Raton, FL: CRC Press; 1982;p. 131–150
  39. Savage DD, Montano CY, Otero MA, Paxton LL. Prenatal ethanol exposure decreases hippocampal NMDA-sensitive [3H]-glutamate binding site density in 45-day-old rats. Alcohol. 1991;8:193–201
  40. Schulman H, Kuret J, Jefferson AB, Nose PS, Spitzer KH. Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues. Biochemistry. 1985;24:5320–5327
  41. Snell LD, Tabakoff B, Hoffman PL. Radioligand binding to the N-methyl-d-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res. 1993;602:91–98
  42. Souza DO, Ramirez G. Effects of guanine nucleotides on kainic acid binding and on adenylate cyclase in chick optic tectum and cerebellum. J Mol Neurosci. 1991;3:39–45
  43. Tobimatsu T, Fujisawa H. Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs. J Biol Chem. 1989;264:17907–17912
  44. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 1979;76:4350–4354
  45. Yamauchi T, Fujisawa H. Tyrosine 3-monoxygenase is phosphorylated by Ca2+-, calmodulin-dependent protein kinase, followed by activation by activator protein. Biochem Biophys Res Commun. 1981;100:807–813

 Editor: T.R. Jerrells

PII: S0741-8329(01)00133-1

Alcohol
Volume 23, Issue 3 , Pages 183-188 , April 2001