Alcohol
Volume 24, Issue 1 , Pages 5-8 , May 2001

Mutational analysis of ethanol interactions with G-protein-coupled inwardly rectifying potassium channels

  • Koji Hara
    • ,
  • Joanne M Lewohl

      Affiliations

    • Present address: Department of Biochemistry, University of Queensland, Brisbane, QLD, Australia 4072.
    • ,
  • Tomohiro Yamakura

      Affiliations

    • Present address: Department of Anesthesiology, Niigata University, School of Medicine, Niigata 951-8510, Japan.
    • ,
  • R.Adron Harris

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-512-232-2514; fax: +1-512-232-2525

Received 27 October 2000 ,Revised 23 January 2001 ,Accepted 31 January 2001.

References 

  1. Dascal N. Signalling via the G protein-activated K+channels. Cell Signal. 1997;9:551–573
  2. Dildy-Mayfield JE, Harris RA. Comparison of ethanol sensitivity of rat brain kainate, dl-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-d-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1992;262:487–494
  3. Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 1996;16:423–429
  4. Jan LY, Jan YN. Cloned potassium channels from eukaryotes and prokaryotes. Annu Rev Neurosci. 1997;20:91–123
  5. Kobayashi T, Ikeda K, Kojima H, Niki H, Yano R, Yoshioka T, et al. Ethanol opens G-protein-activated inwardly rectifying K+channels. Nat Neurosci. 1999;2:1091–1097
  6. Kovoor A, Henry DJ, Chavkin C. Agonist-induced desensitization of the μ opioid receptor-coupled potassium channel (GIRK1). J Biol Chem. 1995;270:589–595
  7. Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA, Harris RA. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci. 1999;2:1084–1090
  8. Mihic SJ, McQuilkin SJ, Eger EI, Ionescu P, Harris RA. Potentiation of γ-aminobutyric acid type A receptor–mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Mol Pharmacol. 1994;46:851–857
  9. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, et al. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature. 1997;389:385–389
  10. Neer EJ. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 1995;80:249–257

☆ A paper published as a high-priority communication is one that reviewers have identified as being of high scientific significance and have recommended that the study findings should be communicated to the scientific community as soon as possible.Editor: T.R. Jerrels

PII: S0741-8329(01)00134-3

Alcohol
Volume 24, Issue 1 , Pages 5-8 , May 2001

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