Alcohol
Volume 24, Issue 3 , Pages 145-153 , July 2001

Importance of extracellular Ca2+ and intracellular Ca2+ release in ethanol-induced contraction of cerebral arterial smooth muscle

  • Zhi-wei Yang

      Affiliations

    • Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • ,
  • Jun Wang

      Affiliations

    • Department of Anesthesiology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • ,
  • Tao Zheng

      Affiliations

    • Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • ,
  • Bella T Altura

      Affiliations

    • Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • The Center for Cardiovascular and Muscle Research, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • ,
  • Burton M Altura

      Affiliations

    • Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • The Center for Cardiovascular and Muscle Research, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    • Department of Medicine, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 31, Brooklyn, NY, 11203, USA
    • Corresponding Author InformationCorresponding author. Box 31, SUNY Health Science Center at Brooklyn, NY 11203, USA. Tel.: +1-718-270-2194; fax: +1-718-270-3103

Received 12 December 2000 ,Revised 26 February 2001 ,Accepted 2 March 2001.

References 

  1. Alborch E, Salom JB, Torregrosa G. Calcium channels in cerebral arteries. Pharmacol Ther. 1995;68:1–34
  2. Altura BM, Altura BT. Microvascular and vascular smooth muscle actions of ethanol, acetaldehyde, and acetate. Fed Proc. 1982;41:2447–2451
  3. Altura BM, Altura BT. Peripheral and cerebrovascular actions of ethanol, acetaldehyde, and acetate: relationship to divalent cations. Alcohol Clin Exp Res. 1987;11:99–111
  4. Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol Clin Exp Res. 1994;18:1057–1068
  5. Altura BM, Altura BT, Carella A, Chatterjee M, Halevy S, Tejani N. Alcohol produces spasms of human umbilical blood vessels: relationship to fetal alcohol syndrome (FAS). Eur J Pharmacol. 1982;86:311–312
  6. Altura BM, Altura BT, Carella A, Gebrewold A, Murakawa T, Nishio A. Mg2+–Ca2+ interaction in contractility of vascular smooth muscle: Mg2+ versus organic calcium channel blockers on myogenic tone and agonist-induced responsiveness of blood vessels. Can J Physiol Pharmacol. 1987;65:729–745
  7. Altura BM, Altura BT, Gebrewold A. Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death. Science. 1983;220:331–333
  8. Altura BM, Edgarian H, Altura BT. Differential effects of ethanol and mannitol on contraction of arterial smooth muscle. J Pharmacol Exp Ther. 1976;197:352–361
  9. Altura BM, Gebrewold A, Zhang A, Altura BT, Gupta RK. Magnesium deficiency exacerbates brain injury and stroke mortality induced by alcohol: a 31P-NMR in vivo study. Alcohol. 1998;15:181–183
  10. Altura BM, Gebrewold A, Zhang A, Wu F, Zou L, Zheng T, et al. Alcohol-induced vascular injury: role of oxygen-derived radicals, antioxidants, cellular bioenergetics, divalent cations, transcription factors and protein kinase C. Internat J Cardiovasc Med Sci. 1999;2:7–24
  11. Altura BM, Zhang A, Cheng TP, Altura BT. Ethanol promotes rapid depletion of intracellular free Mg in cerebral vascular smooth muscle cells: possible relation to alcohol-induced behavioral and stroke-like effects. Alcohol. 1993;10:563–566
  12. Altura BM, Zhang A, Cheng TP, Altura BT. Exposure of piglet coronary arterial muscle cells to low alcohol results in elevation of intracellular free Ca2+: relevance to fetal alcohol syndrome. Eur J Pharmacol. 1996;314:R9–R11
  13. Altura BT, Altura BM. Withdrawal of magnesium causes vasospasm while elevated magnesium produces relaxations of tone in cerebral arteries. Neurosci Lett. 1980;20:323–327
  14. Altura BT, Pohorecky LA, Altura BM. Demonstration of tolerance to ethanol in non-nervous tissue: effects on vascular smooth muscle. Alcohol Clin Exp Res. 1980;4:62–69
  15. Barbour RL, Gebrewold A, Altura BM. Optical spectroscopy and cerebral vascular effects of alcohol in the intact brain: effects on tissue deoxyhemoglobin, blood content, and reduced cytochrome oxidase. Alcohol Clin Exp Res. 1993;17:1319–1324
  16. Camargo CA. Moderate alcohol consumption and stroke. The epidemiologic evidence. Stroke. 1989;20:1611–1626
  17. Donahue RP, Abbott RD, Reed DM, Yano K. Alcohol and hemorrhagic stroke. The Honolulu Heart Program. JAMA. 1986;255:2311–2314
  18. Ema M, Gebrewold A, Altura BT, Zhang A, Altura BM. Alcohol-induced vascular damage of brain is ameliorated by administration of magnesium. Alcohol. 1998;15:95–103
  19. Farago M, Szabo C, Horvath I, Dora E, Kovach AG. Differential vascular actions of ethanol in feline middle cerebral and mesenteric artery. Acta Physiol Hung. 1991;78:119–125
  20. Gordon EL, Nguyen TS, Ngai AC, Winn HR. Differential effects of alcohols on intracerebral arterioles. Ethanol alone causes vasoconstriction. J Cereb Blood Flow Metab. 1995;15:532–538
  21. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440–3450
  22. Guibert C, Marthan R, Savineau JP. Oscillatory Cl− current induced by angiotensin II in rat pulmonary arterial myocytes: Ca2+ dependence and physiological implication. Cell Calcium. 1997;21:421–429
  23. Hillbom M. Alcohol consumption and stroke: benefits and risks. Alcohol Clin Exp Res. 1998;22(7 Suppl):352S–358S
  24. Hillbom M, Numminen H. Alcohol and stroke: pathophysiologic mechanisms. Neuroepidemiology. 1998;17:281–287
  25. Johnson ME, Sill JC, Brown DL, Halsey TJ, Uhl CB. The effect of the neurolytic agent ethanol on cytoplasmic calcium in arterial smooth muscle and endothelium. Reg Anesth. 1996;21:6–13
  26. Jover T, Altura BT, Altura BM. Effects of protein kinase C inhibitors on ethanol-induced contractions in isolated rat aorta. Alcohol. 1999;18:17–22
  27. Kalant H. Effects of ethanol on the nervous system. In:  Tremolleres J editors. International Encyclopedia of Pharmacology and Therapeutics. Section 20: Alcohols and Derivatives. New York: Pergamon; 1970;p. 189–236
  28. Kuroiwa M, Aoki H, Kobayashi S, Nishimura J, Kanaide H. Role of GTP-protein and endothelium in contraction induced by ethanol in pig coronary artery. J Physiol. 1993;470:521–537
  29. Li W, Zheng T, Wang J, Altura BT, Altura BM. Pyrrolidine dithiocarbamate prevents ethanol-induced elevation of [Ca2+]i in cultured canine cerebral vascular smooth muscle cells. Neurosci Lett. 1999;266:205–208
  30. Pinardi G, Brieva C, Vinet R, Penna M. Effects of chronic ethanol consumption on alpha-adrenergic-induced contractions in rat thoracic aorta. Gen Pharmacol. 1992;23:245–248
  31. Sedgewick J. A New Treatise on Liquors Wherein the Use and Abuse of Wine, Malt Drinks, Water, Etc, are Particularly Considered in Many Diseases, Institutions, and Ages with Proper Manner of Using Them Hot or Cold Either as Physik, Diet or Both. London: Rivington; 1925;
  32. Thayer SA, Hirning LD, Miller RJ. The role of caffeine-sensitive calcium stores in the regulation of the intracellular free calcium concentration in rat sympathetic neurons in vitro. Mol Pharmacol. 1988;34:664–673
  33. Volpe P, Alderson-Lang BH, Nickols GA. Regulation of inositol 1,4,5,-trisphosphate-induced Ca2+ release. I. Effect of Mg2+. Am J Physiol. 1990;258:C1077–C1085
  34. Werber AH, Morgan RA, Zhou P, Yang C. Intracellular mechanisms of constriction of rat aorta by ethanol. Alcohol. 1997;14:351–360
  35. Zhang A, Altura BT, Altura BM. Ethanol-induced contraction of cerebral arteries in diverse mammals and its mechanism of action. Eur J Pharmacol. 1993;248:229–236
  36. Zhang A, Cheng TP, Altura BM. Magnesium regulates intracellular free ionized calcium concentration and cell geometry in vascular smooth muscle cells. Biochim Biophys Acta. 1992;1134:25–29
  37. Zhang A, Cheng TP, Altura BT, Altura BM. Chronic treatment of cultured cerebral vascular smooth cells with low concentration of ethanol elevates intracellular calcium and potentiates prostanoid-induced rises in [Ca2+]i: relation to etiology of alcohol-induced stroke. Alcohol. 1997;14:367–371
  38. Zheng T, Li W, Zhang A, Altura BT, Altura BM. Alpha-tocopherol prevents ethanol-induced elevation of [Ca2+]i in cultured canine cerebral vascular smooth muscle cells. Neurosci Lett. 1998;245:17–20

☆ A paper published as a high-priority communication is one that reviewers have identified as being of high scientific significance and have recommended that the study findings should be communicated to the scientific community as soon as possible.

PII: S0741-8329(01)00145-8

doi: 10.1016/S0741-8329(01)00145-8

Alcohol
Volume 24, Issue 3 , Pages 145-153 , July 2001

Article Tools

* Image Usage & Resolution