Alcohol
Volume 24, Issue 3 , Pages 197-204 , July 2001

Differential effects of acute ethanol treatment on cardiac contractile function in young adult and senescent mice

  • Jiaqi Shi

      Affiliations

    • Arizona Prevention Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • ,
  • Douglas F Larson

      Affiliations

    • Sarver Heart Center, Room 4402, Department of Surgery, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-520-626-6494; fax: +1-520-626-4042
    • ,
  • Bo Yang

      Affiliations

    • Sarver Heart Center, Room 4402, Department of Surgery, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • ,
  • Kyler Hunter

      Affiliations

    • Sarver Heart Center, Room 4402, Department of Surgery, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • ,
  • Mark Gorman

      Affiliations

    • Sarver Heart Center, Room 4402, Department of Surgery, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • ,
  • Sergio Montes

      Affiliations

    • Arizona Prevention Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • ,
  • Julie Beischel

      Affiliations

    • Sarver Heart Center, Room 4402, Department of Surgery, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    • ,
  • Ronald R Watson

      Affiliations

    • Arizona Prevention Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA

Received 26 May 2000 ,Revised 16 April 2001 ,Accepted 21 April 2001.

References 

  1. Balligand JL, Cannon PJ. Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences. Arterioscler Thromb Vasc Biol. 1997;17:1846–1858
  2. Brown RA, Savage AO, Lloyd TC. Influence of age on the inotropic response to acute ethanol exposure in spontaneously hypertensive rats. Hypertension. 1996;28:872–879
  3. Chen QM, LaBella FS. Inhibition of nitric oxide synthase by straight chain and cyclic alcohols. Eur J Pharmacol. 1997;321:355–360
  4. Chick J. Alcohol, health, and the heart: implications for clinicians. Alcohol Alcohol. 1998;33:576–591
  5. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Anal Biochem. 1987;162:156–159
  6. Corda S, Mebazaa A, Tavernier B, Ayed MB, Payen D. Paracrine regulation of cardiac myocytes in normal and septic heart. J Crit Care. 1998;13:39–47
  7. Figueredo VM. The effects of alcohol on the heart: detrimental or beneficial?. Postgrad Med. 1997;101:165–172,175
  8. Glower DD, Spratt JA, Snow ND, Kabas JS, Davis JW, Olsen CO, et al. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation. 1985;71:994–1009
  9. Greenberg S, Xie J, Kolls J, Nelson S, Didier P, Mason C. Ethanol suppresses Mycobacteria tuberculosis–induced mRNA for nitric oxide synthase in alveolar macrophages, in vivo. Alcohol Clin Exp Res. 1995;19:394–401
  10. Greenberg SS, Ouyang J, Zhao X, Xie J, Wang JF, Giles TD. Interaction of ethanol with inducible nitric oxide synthase messenger RNA and protein: direct effects on autacoids and endotoxin in vivo. J Pharmacol Exp Ther. 1997;282:1044–1054
  11. Greenberg SS, Xie J, Wang Y, Kolls J, Malinski T, Summer WR, et al. Ethanol suppresses LPS-induced mRNA for nitric oxide synthase II in alveolar macrophages in vivo and in vitro. Alcohol. 1994;11:539–547
  12. Hininger I, Ribiere C, Nordmann R. Disturbances in myocardial creatine kinase following ethanol administration to rats — trials of prevention by allopurinol, desferrioxamine and propranolol. Alcohol Alcohol. 1991;26:303–307
  13. Jahn H, Nastainczyk W, Rohrkasten A, Schneider T, Hofmann F. Site-specific phosphorylation of the purified receptor for calcium-channel blockers by cAMP- and cGMP-dependent protein kinases, protein kinase C, calmodulin-dependent protein kinase II and casein kinase II. Eur J Biochem. 1988;178:535–542
  14. Kass DA, Yamazaki T, Burkhoff D, Maughan WL, Sagawa K. Determination of left ventricular end-systolic pressure–volume relationships by the conductance (volume) catheter technique. Circulation. 1986;73:586–595
  15. Kay HH, Grindle KM, Magness RR. Ethanol exposure induces oxidative stress and impairs nitric oxide availability in the human placental villi: a possible mechanism of toxicity. Am J Obstet Gynecol. 2000;182:682–688
  16. Kimura H, Miura S, Higuchi H, Kurose I, Tsuzuki Y, Shigematsu T, et al. Effect of chronic ethanol feeding on nitric oxide synthesis by rat Kupffer cells. Alcohol Clin Exp Res. 1996;20(1 Suppl):69A–72A
  17. Kurose I, Higuchi H, Watanabe N, Miura S, Tomita K, Yonei Y, et al. CD18/ICAM-1-dependent nitric oxide production of Kupffer cells as a cause of mitochondrial dysfunction in hepatoma cells: influence of chronic alcohol feeding. Free Radic Biol Med. 1997;22:229–239
  18. Lakatta EG. Cardiovascular aging in health. Clin Geriatr Med. 2000;16:419–444
  19. Li HL, Moreno-Sanchez R, Rottenberg H. Alcohol inhibits the activation of NAD-linked dehydrogenases by calcium in brain and heart mitochondria. Biochim Biophys Acta. 1995;1236:306–316
  20. Lohmann SM, Fischmeister R, Walter U. Signal transduction by cGMP in heart [editorial]. Basic Res Cardiol. 1991;86:503–514
  21. McCann SM, Licinio J, Wong ML, Yu WH, Karanth S, Rettorri V. The nitric oxide hypothesis of aging. Exp Gerontol. 1998;33:813–826
  22. Meszaros LG, Minarovic I, Zahradnikova A. Inhibition of the skeletal muscle ryanodine receptor calcium release channel by nitric oxide. FEBS Lett. 1996;380:49–52
  23. Nicolas JM, Antunez E, Thomas AP, Fernandez-Sola J, Tobias E, Estruch R, et al. Ethanol acutely decreases calcium transients in cultured human myotubes. Alcohol Clin Exp Res. 1998;22:1086–1092
  24. Opie LH. Regulation of myocardial contractility. J Cardiovasc Pharmacol. 1995;26(Suppl 1):S1–S9
  25. Stein B, Frank P, Schmitz W, Scholz H, Thoenes M. Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase. J Mol Cell Cardiol. 1996;28:1631–1639
  26. Strasser RH, Nuchter I, Rauch B, Marquetant R, Seitz H. Changes in cardiac signal transduction systems in chronic ethanol treatment preceding the development of alcoholic cardiomyopathy. Herz. 1996;21:232–240
  27. Syapin PJ. Ethanol inhibition of inducible nitric oxide synthase activity in C6 glioma cells. Alcohol Clin Exp Res. 1995;19:262–267
  28. Syapin PJ, Rendon A, Huron DR, Militante JD. Effects of short chain alkanols on the inducible nitric oxide synthase in a glial cell line. Br J Pharmacol. 1999;126:1253–1261
  29. Wang E, Spitzer JJ, Chamulitrat W. Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1. Nitric Oxide. 1999;3:244–253
  30. Wilke A, Kaiser A, Ferency I, Maisch B. Alcohol and myocarditis. Herz. 1996;21:248–257
  31. Xie J, Kolls J, Bagby G, Greenberg SS. Independent suppression of nitric oxide and TNF alpha in the lung of conscious rats by ethanol. FASEB J. 1995;9:253–261
  32. Yang B, Larson DF, Watson R. Age-related left ventricular function in the mouse: analysis based on in vivo pressure–volume relationships. Am J Physiol. 1999;277:H1906–H1913
  33. Zhao X, Jie O, Li H, Xie J, Giles TD, Greenberg SS. Ethanol inhibits inducible nitric oxide synthase transcription and post-transcriptional processes in vivo. Alcohol Clin Exp Res. 1997;21:1246–1256
  34. Zhao X, Jie O, Li H, Xie J, Greenberg SS. Ethanol inhibits the potentiation of endotoxin by dibutyryl cAMP and 2-methylthio ATP in vivo. Alcohol Clin Exp Res. 1998;22:1662–1672

PII: S0741-8329(01)00154-9

doi: 10.1016/S0741-8329(01)00154-9

Alcohol
Volume 24, Issue 3 , Pages 197-204 , July 2001

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