Alcohol
Volume 25, Issue 3 , Pages 185-188 , November 2001

Carbohydrate-deficient transferrin for detection and monitoring of sustained heavy drinking: What have we learned? Where do we go from here?

  • Raymond F. Anton

      Affiliations

    • Dr. Anton is a consultant for Axis-Shield ASA of Oslo, Norway.
    • Corresponding Author InformationCorresponding author. Tel.: +1-843-792-1226; fax: +1-843-792-1724

Received 26 December 2000 ,Revised 4 May 2001 ,Accepted 15 May 2001.

References 

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  2. Allen JP, Litten RZ, Fertig JB, Sillanaukee P. Carbohydrate-deficient transferrin, γ-glutamyltransferase, and macrocytic volume as biomarkers of alcohol problems in women. Alcohol Clin Exp Res. 2000;24:492–496
  3. Allen JP, Sillanaukee P, Anton R. Contribution of carbohydrate deficient transferrin to gamma glutamyl transpeptidase in evaluating progress of patients in treatment from alcoholism. Alcohol Clin Exp Res. 1999;23:115–120
  4. Anton R, Bean P. Two methods for measuring carbohydrate-deficient transferrin in inpatient alcoholics and healthy controls compared. Clin Chem. 1994;40:364–368
  5. Anton RF. The use of carbohydrate deficient transferrin as an indicator of alcohol consumption during treatment and follow-up. Alcohol Clin Exp Res. 1996;20(8 Suppl):54A–56A
  6. Anton RF, Dominick C, Bigelow M, Westby C. Comparison of Bio-Rad %CDT TIA and CDTect as laboratory markers of heavy alcohol use and their relationships with gamma-glutamyl transferase. Clin Chem. 2001;47:1769–1775
  7. Bean P, Liegmann K, Lovli T, Westby C, Sundrehagen E. Semiautomated procedures for evaluation of carbohydrate-deficient transferrin in the diagnosis of alcohol abuse. Clin Chem. 1997;43:983–989
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  9. De Feo TM, Fargion S, Duca L, Mattioli M, Cappellini MD, Samprieto M, et al. Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron. Hepatology. 1999;29:658–663
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  12. Meerkerk G-J, Njoo KH, Bongers IMB, Trienekens P, van Oers JAM. The specificity of the CDT assay in general practice: the influence of common chronic diseases and medication on the serum CDT concentration. Alcohol Clin Exp Res. 1998;22:908–913
  13. Mitchell C, Simpson D, Chick J. Carbohydrate deficient transferrin in detecting relapse in alcohol dependence. Drug Alcohol Depend. 1997;48:97–103
  14. Oslin DW, Pettinati HM, Luck G, Semwanga A, Cnaan A, O'Brien CP. Clinical correlations with carbohydrate-deficient transferrin levels in women with alcoholism. Alcohol Clin Exp Res. 1998;22:1981–1985
  15. Schmidt LG, Schmidt K, Dufeu P, Ohse A, Rommelspacher H, Muller C. Superiority of carbohydrate-deficient transferrin to γ-glutamyltransferase in detecting relapse in alcoholism. Am J Psychiatry. 1997;154:75–80
  16. Simonsson P, Lindberg S, Alling C. Carbohydrate-deficient transferrin measured by high-performance liquid chromatography and CDTect immunoassay. Alcohol Alcohol. 1996;31:397–402
  17. Stibler H, Borg S, Joustra M. Micro anion exchange chromatography of carbohydrate-deficient transferrin in serum in relation to alcohol consumption (Swedish Patent 8400587-5). Alcohol Clin Exp Res. 1986;10:535–544
  18. Viitala K, Lahdesmaki K, Niemela O. Comparison of the Axis %CDT TIA and the CDTect method as laboratory tests of alcohol abuse. Clin Chem. 1998;44:1209–1215

PII: S0741-8329(01)00165-3

Alcohol
Volume 25, Issue 3 , Pages 185-188 , November 2001

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