Alcohol
Volume 25, Issue 2 , Pages 77-81 , October 2001

Chronic ethanol consumption increases homocysteine accumulation in hepatocytes

Received 7 September 2000 ,Revised 9 May 2001 ,Accepted 27 May 2001.

References 

  1. Barak AJ, Beckenhauer HC. The influence of ethanol on hepatic transmethylation. Alcohol Alcohol. 1988;23:73–77
  2. Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res. 1997;21:1100–1102
  3. Barak AJ, Beckenhauer HC, Junnila M, Tuma DJ. Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res. 1993;17:552–555
  4. Barak AJ, Beckenhauer HC, Tuma DJ. Ethanol feeding inhibits the activity of hepatic N5-methyltetrahydrofolate-homocysteine methyltransferase in the rat. IRCS Med Sci. 1985;13:760–761
  5. Barak AJ, Beckenhauer HC, Tuma DJ, Donohue TM. Adaptive increase in betaine-homocysteine methyltransferase activity maintains hepatic S-adenosylmethionine levels in ethanol-treated rats. IRCS Med Sci. 1984;12:866–867
  6. Constans J, Blann AD, Resplandy F, Parrot F, Renard M, Seigneur M, et al. Three months supplementation of hyperhomocysteinaemic patients with folic acid and vitamin B6 improves biological markers of endothelial dysfunction. Br J Haematol. 1999;107:776–778
  7. Constans J, Blann AD, Resplandy F, Parrot F, Seigneur M, Renard M, et al. Endothelial dysfunction during acute methionine load in hyperhomocysteinaemic patients. Atherosclerosis. 1999;147:411–413
  8. Cornwall PE, Morgan SL, Vaughn WH. Modification of a HPLC method for assay of homocysteine in human plasma. J Chromatogr. 1993;617:136–139
  9. Cravo ML, Camilo ME. Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamin B6 and B12 status. Nutrition. 2000;16:296–302
  10. Finkelstein JD, Martin JJ, Harris BJ, Kyle WE. Regulation of the betaine content of rat liver. Arch Biochem Biophys. 1982;218:169–173
  11. Fonseca V, Guba SC, Fink LM. Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis. Endocr Rev. 1999;20:738–759
  12. Hultberg B, Berglund M, Andersson A, Frank A. Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res. 1993;17:687–689
  13. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  14. Jacobsen DW. Homocysteine and vitamins in cardiovascular disease. Clin Chem. 1998;44:1833–1843
  15. Jakubowski H. Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J. 1999;13:2277–2283
  16. Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR, Haynes WG. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation. 1999;100:1161–1168
  17. Lieber CS, DeCarli LM. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol. 1989;24:197–211
  18. Refsum H, Fiskerstrand T, Guttormsen AB, Ueland PM. Assessment of homocysteine status. J Inherit Metab Dis. 1997;20:286–294
  19. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol. 1976;13:29–83
  20. Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217–246
  21. Stickel F, Choi SW, Kim YI, Bagley PJ, Seitz HK, Russell RM, et al. Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res. 2000;24:259–264
  22. Torres L, Garcia-Trevijano ER, Rodriguez JA, Carretero MV, Bustos M, Fernandez E, et al. Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes: a new role for homocysteine in liver fibrosis. Biochim Biophys Acta. 1999;1455:12–22

PII: S0741-8329(01)00168-9

Alcohol
Volume 25, Issue 2 , Pages 77-81 , October 2001