Alcohol
Volume 25, Issue 2 , Pages 115-122 , October 2001

No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study

  • Matts Eriksson

      Affiliations

    • Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgren University Hospital/Mölndal, SE-431 80 Mölndal, Sweden
  • ,
  • Claudia Fahlke

      Affiliations

    • Department of Psychology, Göteborg University, SE-405 30 Göteborg, Sweden
    • Corresponding Author InformationCorresponding author. Department of Psychology, Göteborg University, P.O. Box 500, SE-405 30 Göteborg, Sweden. Tel.: +46-31-7734289; fax: +46-31-7734628
  • ,
  • Stefan Hansen

      Affiliations

    • Department of Psychology, Göteborg University, SE-405 30 Göteborg, Sweden
  • ,
  • Ulf Berggren

      Affiliations

    • Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgren University Hospital/Mölndal, SE-431 80 Mölndal, Sweden
  • ,
  • Per Mårin

      Affiliations

    • Institute of Heart and Lung Diseases, Sahlgren University Hospital, SE-431 45 Göteborg, Sweden
  • ,
  • Jan Balldin

      Affiliations

    • Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgren University Hospital/Mölndal, SE-431 80 Mölndal, Sweden

Received 14 September 2000 ,Revised 25 April 2001 ,Accepted 25 June 2001.

References 

  1. Adinoff B, Martin PR, Bone GH, Eckardt MJ, Roechrich L, George DT, et al. Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch Gen Psychiatry. 1990;47:325–330
  2. Alho H, Heinälä P, Kuoppasalmi K, Lönnqvist J, Kiianmaa K, Sinclair D. Naltrexone for alcohol dependence: double-blind placebo-controlled Finnish trial. Alcohol Clin Exp Res. 1999;23(suppl 5):A246
  3. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Association Press; 1944;
  4. Armario A, López-Calderón A, Jolin T, Castellanos JM. Sensitivity of anterior pituitary hormones to graded levels of psychological stress. Life Sci. 1986;39:471–475
  5. Armario A, Marti O, Molina T, de Pablo J, Valdes Mtitle>Acute stress markers in humans: response of plasma glucose, cortisol and prolactin to two examinations differing in the anxiety they provoke. Psychoneuroendocrinology. 1996;21:17–24
  6. Balldin J, Berggren U, Engel J, Eriksson M, Hård E, Söderpalm B. Effect of citalopram on alcohol intake in heavy drinkers. Alcohol Clin Exp Res. 1994;18:1133–1136
  7. Bergman H, Bergman I, Engelbrektsson K, Holm L, Johannesson K, Lindberg S. Psykologhandbok vid Magnus Huss klinik. Stockholm: Karolinska Sjukhuset; 1982;
  8. Bernardy NC, King AC, Parson OA, Lovallo WR. Altered cortisol response in sober alcoholics: an examination of contributing factors. Alcohol. 1996;13:493–498
  9. Brady KT, Sonne SC. The role of stress in alcohol use, alcoholism treatment, and relapse. Alcohol Res Health. 1999;23:263–271
  10. Cappell H, Greeley J. Alcohol and tension reduction: an update on research and theory. In:  Blane HT,  Leornad KE editor. Psychological Theories of Drinking and Alcoholism. New York: Guilford Press; 1987;p. 15–55
  11. Chutuape MA, de Wit H. Preferences for ethanol and diazepam in anxious individuals: an evaluation of the self-medication hypothesis. Psychopharmacology (Berl). 1995;121:91–103
  12. Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science. 1987;236:410–416
  13. Cloninger CR. Anxiety and theories of emotion. In:  Noyes R,  Roth M,  Burrows GD editor. Handbook of Anxiety, Vol. 2: Classification, Etiological Factors and Associated Disturbances. Amsterdam: Elsevier Science; 1988;p. 1–29
  14. Cloninger CR, Bohman M, Sigvardsson S. Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry. 1981;38:861–868
  15. Colton T. Statistics in Medicine. Boston: Little, Brown; 1974;
  16. Fahlke C, Engel JA, Eriksson CJP, Hård E, Söderpalm B. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol. 1994;11:195–202
  17. Fahlke C, Hård E, Thomasson R, Engel JA, Hansen S. Metyrapone-induced suppression of corticosterone synthesis reduces ethanol consumption in high-preferring rats. Pharmacol Biochem Behav. 1994;48:977–981
  18. Fahlke C, Hansen S. Effect of local intracerebral corticosterone implants on alcohol intake in the rat. Alcohol Alcohol. 1999;34:851–861
  19. Fahlke C, Hård E, Eriksson CJP, Engel JA, Hansen S. Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosteroid receptor antagonists. Psychopharmacology (Berl). 1995;117:216–224
  20. Fahlke C, Hård E, Hansen S. Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone. Psychopharmacolgy. 1996;127:133–139
  21. Fahlke C, Lorenz JG, Long J, Champoux M, Suomi SJ, Higley JD. Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates. Alcohol Clin Exp Res. 2000;24:644–650
  22. Ganong WF. In: Review of Medical Physiology. Los Altos: Lange Medical Publications; 1971;p. 271–272
  23. Goeders NE, Guerin GF. Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats. Brain Res. 1996;722:145–152
  24. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:55–62
  25. Hamilton M. The assessment of anxiety states by rating. J Neurol Neurosurg Psychiatry. 1960;23:55–62First published in Br J Psychol 32, 50–55, 1959
  26. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6:278–296
  27. Hansen S, Fahlke C, Hård E, Engel JA. Adrenal corticosteroids modulate the consumption of ethanol in the rat. In:  Palomo T,  Archer T editor. Strategies for Studying Brain Disorders: Depressive, Anxiety and Drug Abuse Disorders. London: Farand Press; 1994;p. 465–479
  28. Hasin D, Paykin A. Dependence symptoms but no diagnosis: diagnostic “orphans” in a 1992 national sample. Drug Alcohol Depend. 1999;53:215–222
  29. Higley JD, Hasert MF, Suomi SJ, Linnoila M. Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption. Proc Natl Acad Sci USA. 1991;88:7261–7265
  30. Jeffcoate W. Alcohol-induced pseudo-Cushing's syndrome. Lancet. 1993;341:676–677
  31. Jenkins JS, Connolly J. Adrenocortical response to ethanol in man. Br Med J. 1968;2:804–805
  32. Kranzler HR. Evaluation and treatment of anxiety symptoms and disorders in alcoholics. J Clin Psychiatry. 1996;57(Suppl. 7):15–21
  33. Kushner MG, Sher KJ, Beitman BD. The relation between alcohol problems and the anxiety disorders. Am J Psychiatry. 1990;147:685–695
  34. Lamblin F, De Witte P. Adrenalectomy prevents the development of alcohol preference in male rats. Alcohol. 1996;13:233–238
  35. Lundberg U, Frankenhaeuser M. Stress and workload of men and women in high-ranking positions. J Occup Health Psychol. 1999;4:142–151
  36. O'Dwyer A-M, Lightman SL, Marks MN, Checkley SA. Treatment of major depression with metyrapone and hydrocortisone. J Affect Disord. 1995;33:123–128
  37. Otto MW, Pollack MH, Sachs GS, O'Neil CA, Rosenbaum JF. Alcohol dependence in panic disorder patients. J Psychiatr Res. 1992;26:29–38
  38. Paton A. Alcohol induced cushingoid syndrome. Br Med J. 1976;2:1504
  39. Piazza PV, Le Moal M. Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol. 1996;36:359–378
  40. Piazza PV, Maccari S, Deminière J-M, Le Moal M, Mormède P, Simon H. Corticosterone levels determine individual vulnerability to amphetamine self-administration. Proc Natl Acad Sci USA. 1991;88:2088–2092
  41. Piazza PV, Marinelli M, Jodogne C, Deroche V, Rouge-Pont F, Maccari S, et al. Inhibition of corticosterone synthesis by metyrapone decreases cocaine-induced locomotion and relapse of cocaine self-administration. Brain Res. 1994;658:259–264
  42. Pollock NK, Martin CS. Diagnostic orphans: adolescents with alcohol symptoms who do not qualify for DSM-IV abuse or dependence diagnoses. Am J Psychiatry. 1999;156:897–901
  43. Prasad C, Prasad A. A relationship between increased voluntary alcohol preference and basal hypercorticosteronemia associated with an attenuated rise in corticosterone output during stress. Alcohol. 1995;12:59–63
  44. Sass H, Soyka M, Mann K, Zieglgänsberger W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry. 1996;53:673–680
  45. Sayette MA. An appraisal-disruption model of alcohol's effects on stress responses in social drinkers. Psychol Bull. 1993;114:459–476
  46. Schalling D. Neurochemical correlates of personality, impulsivity, and disinhibitory suicidality. In:  Hodgkins S editors. Mental Disorder and Crime. New York: Sage Publications; 1993;p. 208–226
  47. Schuckit MA, Hesselbrock V. Alcohol dependence and anxiety disorders: what is the relationship?. Am J Psychiatry. 1994;151:1723–1734
  48. Wand GS, Dobs AS. Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. Clin Endocrinol Metab. 1991;72:1290–1295

PII: S0741-8329(01)00173-2

Alcohol
Volume 25, Issue 2 , Pages 115-122 , October 2001