Alcohol
Volume 25, Issue 3 , Pages 171-172 , November 2001

Alcohol biomarkers: clinical significance and biochemical basis

  • M.Raj Lakshman

      Affiliations

    • The Lipid Research Laboratory, DVA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    • Department of Medicine, The George Washington University, Washington, DC 20037, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-202-745-8330; fax: +1-202-462-2006
    • ,
  • Mikihiro Tsutsumi

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan

Received 9 August 2001 ,Revised 20 August 2001 ,Accepted 17 September 2001.

References 

  1. Ghosh P, Hale EA, Lakshman MR. Long-term ethanol exposure alters the sialylation index of plasma apolipoprotein J (Apo J) in rats. Alcohol Clin Exp Res. 1999;23:720–725
  2. Lakshman MR, Rao MN, Marmillot P. Alcohol and molecular regulation of protein glycosylation and function. Alcohol. 1999;19:239–247
  3. Marmillot P, Rao MN, Lakshman MR. Chronic ethanol exposure in rats affects rabs-depndent hepatic trafficking of apolipoprotein E and transferrin. Alcohol. 2001;25:195–200
  4. Mitchell C, Simpson D, Chick J. Carbohydrate deficient transferrin in detecting relapse in alcohol dependence. Drug Alcohol Depend. 1997;48:97–103
  5. Stibler H, Borg S, Joustra M. Micro anion exchange chromatography of carbohydrate-deficient transferrin in serum in relation to alcohol consumption (Swedish Patent 8400587-5). Alcohol Clin Exp Res. 1986;10:535–544
  6. Thiele GM, Tuma DJ, Willis MS, Miller JA, McDonald TL, Sorrell MF, et al. Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant. Alcohol Clin Exp Res. 1998;22:1731–1739
  7. Tsutsumi M, Wang JS, Takada A. Microheterogeneity of serum glycoproteins in alcoholics: is desialo-transferrin the marker of chronic alcohol drinking or alcoholic liver injury?. Alcohol Clin Exp Res. 1994;18:392–397
  8. Tuma DJ, Jennett RB, Sorrell MF. Effect of ethanol on the synthesis and secretion of hepatic secretory glycoproteins and albumin. Hepatology. 1981;1:590–598

PII: S0741-8329(01)00189-6

Alcohol
Volume 25, Issue 3 , Pages 171-172 , November 2001

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