Alcohol
Volume 27, Issue 1 , Pages 43-46 , May 2002

Alcoholic hepatitis: inflammatory cell–mediated hepatocellular injury

  • Samuel W. French

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA. Tel.: +1-310-222-2643; fax: +1-310-222-5333.(S.W. French)

Received 23 November 2001 ,Revised 18 January 2002 ,Accepted 3 February 2002.

References 

  1. Adams DH. Leucocyte adhesion molecules and alcoholic liver disease. Alcohol Alcohol. 1994;29:249–260
  2. Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology. 1996;23:155–163
  3. Albano E, French SW, Ingelman-Sundberg M. Hydroxyethyl radicals in ethanol hepatotoxicity. Front Biosci. 1999;4:D533–D540
  4. Chedid A, Mendenhall CL, Moritz TE, French SW, Chen TS, Morgan TR, et al. Cell-mediated hepatic injury in alcoholic liver disease. Gastroenterology. 1993;105:254–266a
  5. Chedid A, Mendenhall CL, Moritz TE, French SW, Chen TS, Morgan TR, et al. Expression of the β1 chain (CD29) of integrins and CD45 in alcoholic liver disease. Am J Gastroenterol. 1993;88:1920–1927b
  6. Chiappelli F, Kung M, Lee P, Pham L, Manfrini E, Villanueva P. Alcohol modulation of human normal T-cell activation, maturation, and migration. Alcohol Clin Exp Res. 1995;19:539–544
  7. Dustin ML, Shaw AS. Costimulation (building an immunological synapse). Science. 1999;283:649–650
  8. French SW. Mechanisms of alcoholic liver injury. Can J Gastroenterol. 2000;14:327–332
  9. French SW, Burbige EJ. Alcoholic hepatitis (clinical, morphologic, pathogenic and therapeutic). In:  Popper HP,  Schaffner F editor. Progress in Liver Diseases Vol. IV. New York: Grune & Stratton; 1979;p. 557–579
  10. French SW, Burbige EJ, Tarder G, Bourke E, Harkin CG, Denton T. Lymphocyte sequestration by the liver in alcoholic hepatitis. Arch Pathol Lab Med. 1979;103:146–152
  11. French SW, Nash J, Shitabata P, Kachi K, Hara C, Chedid A, et al. Pathology of alcoholic liver disease. Semin Liver Dis. 1993;13:154–169
  12. Gouillon Z, Lucas D, Li J, Hagbjork AL, French BA, Fu P, et al. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proc Soc Exp Biol Med. 2000;224:302–308
  13. Huang J-F, Yang Y, Sepulveda H, Shi W, Hwang I, Peterson PA, et al. TCR-Mediated internalization of peptide–MHC complexes acquired by T cells. Science. 1999;286:952–954
  14. Hwang I, Sprent J. Role of the actin cytoskeleton in T cell absorption and internalization of ligands from APC. J Immunol. 2001;166:5099–5107
  15. Lalor PF, Adams DH. Adhesion of lymphocytes to hepatic endothelium. Mol Pathol. 1999;52:214–219
  16. Lytton SD, Helander A, Zhang-Gouillon Z-Q, Stokkeland K, Bordone R, Arico S, et al. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Mol Pharmacol. 1999;55:223–233
  17. Paronetto F. Immunologic reactions in alcoholic liver disease. Semin Liver Dis. 1993;13:183–195
  18. Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C–infected liver. J Immunol. 1999;163:6236–6243
  19. Wang MX, Morgan T, Lungo W, Wang L, Sze GZ, French SW. “Piecemeal” necrosis (renamed troxis necrosis). Exp Mol Pathol. 2001;71:137–146

☆ Editor: T.R. Jerrells

PII: S0741-8329(02)00205-7

Alcohol
Volume 27, Issue 1 , Pages 43-46 , May 2002

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