Alcohol
Volume 27, Issue 1 , Pages 53-61 , May 2002

Monocyte activation in alcoholic liver disease

  • Craig J. McClain

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    • Veterans Administration, Louisville, KY 40292, USA
    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, University of Louisville Medical Center, 550 S. Jackson St., ACB 3rd Floor, Louisville, KY 40292, USA. Tel.: +1-502-852-6991; fax: +1-502-852-0846.(C.J. McClain)
  • ,
  • Daniell B. Hill

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
  • ,
  • Zhenyuan Song

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
  • ,
  • Ion Deaciuc

      Affiliations

    • Department of Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
  • ,
  • Shirish Barve

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA

Received 18 December 2001 ,Revised 25 January 2002 ,Accepted 9 February 2002.

References 

  1. Anderson KV. Toll signaling pathways in the innate immune response. Curr Opinion Immunol. 2000;12:13–19
  2. Antal-Szalmas P. Evaluation of CD14 in host defence. Eur J Clin Invest. 2000;30:167–179
  3. Beutler B. Tlr4 (central component of the sole mammalian LPS sensor). Curr Opin Immunol. 2000;12:20–26
  4. Beutler B, Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature. 1986;320:584–588
  5. Bigatello LM, Broitman SA, Fattori L, Di Paoli M, Pontello M, Bevilacqua G, et al. Endotoxemia, encephalopathy, and mortality in cirrhotic patients. Am J Gastroenterol. 1987;82:11–15
  6. Bird GLA, Sheron N, Goka AK, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med. 1990;112:917–920
  7. Bjarnason I, Peters TJ, Wise RJ. The leaky gut of alcoholism (possible route of entry for toxic compounds). Lancet. 1984;1:179–182
  8. Bode C, Kugler V, Bode JC. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol. 1987;4:8–14
  9. Boosalis MG, Ott L, Levine AS, Slag MF, Morley JE, Young B, et al. Relationship of visceral proteins to nutritional status in chronic and acute stress. Crit Care Med. 1989;17:741–747
  10. Bowie A, O'Neill LAJ. The interleukin-1 receptor/Toll-like receptor superfamily (signal generators for pro-inflammatory interleukins and microbial products). J Leukoc Biol. 2000;67:508–514
  11. Devalaraja MN, McClain CJ, Barve S, Vaddi K, Hill DB. Increased monocyte MCP-1 production in acute alcoholic hepatitis. Cytokine. 1999;11:875–881
  12. Deviere J, Content J, Denys C, Vandenbussche P, Schandene L, Wybran J, et al. Excessive in vitro bacterial lipopolysaccharide-induced production of monokines in cirrhosis. Hepatology. 1990;11:628–634
  13. D'Inca R, Di Leo V, Corrao G, Martines D, D'Odorico A, Mestriner C, et al. Intestinal permeability test as a predictor of clinical course in Crohn's disease. Am J Gastroenterol. 1999;94:2956–2960
  14. D'Souza NB, Bagby GJ, Nelson S, Lang CH, Spitzer JJ. Acute alcohol infusion suppresses endotoxin-induced tumor necrosis factor. Alcohol Clin Exp Res. 1989;13:295–298
  15. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, et al. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology. 1998;115:443–451
  16. Felver ME, Mezey E, McGuire M, Mitchell MC, Herlong HF, Veech GA, et al. Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res. 1990;14:255–259
  17. Fenton MJ, Golenbock DT. LPS-binding proteins and receptors. J Leukoc Biol. 1998;64:25–32
  18. Ferro D, Basili S, Praticó D, Iuliano L, FitzGerald GA, Violi F. Vitamin E reduces monocyte tissue factor expression in cirrhotic patients. Blood. 1999;93:2945–2950
  19. Fisher NC, Neil DA, Williams A, Adams DH. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1α in alcoholic liver disease. Gut. 1999;45:416–420
  20. Fujimoto M, Uemura M, Nakatani Y, Tsujita S, Hoppo K, Tamagawa T, et al. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis (relation to severity of liver disturbance). Alcohol Clin Exp Res. 2000;24:48S–54S
  21. Gaetke LM, McClain CJ, Talwalkar RT, Shedlofsky SI. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272:E952–E956
  22. Galati JS, Holdeman KP, Dalrymple GV, Harrison KA, Quigley EMM. Delayed gastric emptying of both the liquid and solid components of a meal in chronic liver disease. Am J Gastroenterol. 1994;89:708–711
  23. Goldblum SE, Cohen DA, Jay M, McClain CJ. Interleukin-1-induced depression of iron and zinc (role of granulocytes and lactoferrin). Am J Physiol. 1987;252:E27–E32
  24. Hanck C, Glatzel M, Singer MV, Rossol S. Gene expression of TNF-receptors in peripheral blood mononuclear cells of patients with alcoholic cirrhosis. J Hepatol. 2000;32:51–57
  25. Hennig B, Honchel R, Goldblum SE, McClain CJ. Tumor necrosis factor–mediated hypoalbuminemia in rabbits. J Nutr. 1988;118:1586–1590
  26. Hill, D., Shedlofsky, S., McClain, C., Diehl, A. M., & Tsukamoto, H. (1997). Cytokines and liver disease. In D. G. Remick, & J. S. Friedland (Eds.), Cytokines in Health and Disease (2nd ed., revised and expanded) (pp. 401–425). New York: Marcel Dekker.
  27. Hill DB, Barve S, Joshi-Barve S, McClain CJ. Increased monocyte nuclear factor-kappaB activation and tumor necrosis factor production in alcoholic hepatitis. J Lab Clin Med. 2000;135:387–395
  28. Hill DB, Devalaraja R, Joshi-Barve SJ, Barve S, McClain CJ. Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro. Clin Biochem. 1999;32:563–570
  29. Hill DB, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. J Lab Clin Med. 1992;119:547–552
  30. Hill DB, Marsano LS, McClain CJ. Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology. 1993;18:576–580
  31. Honchel R, Ray MB, Marsano L, Cohen D, Lee E, Shedlofsky S, et al. Tumor necrosis factor in alcohol enhanced endotoxin liver injury. Alcohol Clin Exp Res. 1992;16:665–669
  32. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, et al. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology. 2000;31:391–398
  33. Isobe H, Sakai H, Satoh M, Sakamoto S, Nawata H. Delayed gastric emptying in patients with liver cirrhosis. Dig Dis Sci. 1994;39:983–987
  34. Jayatilleke A, Shaw S. Stimulation of monocyte interleukin-8 by lipid peroxidation products (a mechanism for alcohol-induced liver injury). Alcohol. 1998;16:119–123
  35. John WJ, Phillips R, Ott L, Adams LJ, McClain CJ. Resting energy expenditure in patients with alcoholic hepatitis. JPEN J Parenter Enteral Nutr. 1989;13:124–127
  36. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology. 1991;13:267–276
  37. Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA, et al. Gender differences in early alcohol-induced liver injury (role of CD14, NF-κB, and TNF-α). Am J Physiol Gastrointest Liver Physiol. 2000;278:G652–G661
  38. Landmann R, Muller B, Zimmerli W. CD14, new aspects of ligand and signal diversity. Microbes Infect. 2000;2:295–304
  39. Le Moine O, Marchant A, De Groote D, Azar C, Goldman M, Deviere J. Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis. Hepatology. 1995;22:1436–1439
  40. Le Moine O, Quertinmont E, Gulbis B, Deviere J. Blunted anti-inflammatory response to adenosine in alcoholic cirrhosis. J Hepatol. 1999;31:457–463
  41. Libert C, Brouckaert P, Fiers W. Protection by α1-acid glycoprotein against tumor necrosis factor–induced lethality. J Exp Med. 1994;180:1571–1575
  42. Lukkari TA, Jarvelainen HA, Oinonen T, Kettunen E, Lindros KO. Short-term ethanol exposure increases the expression of Kupffer cell CD14 receptor and lipopolysaccharide binding protein in rat liver. Alcohol Alcohol. 1999;34:311–319
  43. Luna-Casado L, Diez-Ruiz A, Gutierrez-Gea F, Santos-Perez JL, Rico-Irles J, Wachter H, et al. Increased peripheral mononuclear cells expression of adhesion molecules in alcoholic cirrhosis (its relation to immune activation). J Hepatol. 1997;27:477–483
  44. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis. 1999;19:205–219
  45. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349–351
  46. McClain CJ, Kasarskis EJ, Marsano L. Zinc and alcohol. In:  Watson RR,  Watzl B editor. Nutrition and Alcohol. Boca Raton, FL: CRC Press; 1992;p. 281–307
  47. McClain CJ, Marsano L, Burk RF, Bacon B. Trace metals in liver disease. Semin Liver Dis. 1991;11:321–339
  48. McClain CJ, McClain ML, Boosalis MG, Hennig B. Zinc and the stress response. Scand J Work Environ Health. 1993;19(Suppl 1):132–133
  49. Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, et al. Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest. 1999;104:805–813
  50. Means TK, Golenbock DT, Fenton MJ. The biology of Toll-like receptors. Cytokine Growth Factor Rev. 2000;11:219–232
  51. Mihm S, Galter D, Droge W. Modulation of transcription factor NF κB activity by intracellular glutathione levels and by variations of the extracellular cysteine supply. FASEB J. 1995;9:246–252
  52. Nelson S, Bagby G, Summer WR. Alcohol suppresses lipopolysaccharide-induced tumor necrosis factor activity in serum and lung. Life Sci. 1989;44:673–676
  53. Oesterreicher C, Pfeffel F, Petermann D, Muller C. Increased in vitro production and serum levels of the soluble lipopolysaccharide receptor sCD14 in liver disease. J Hepatol. 1995;23:396–402
  54. Parlesak A, Bode JC, Bode C. Parallel determination of gut permeability in man with Mr 400, Mr 1500, Mr 4000 and Mr 10,000 polyethylene glycol. Eur J Clin Chem Clin Biochem. 1994;32:813–820
  55. Pena LR, Hill DB, McClain CJ. Treatment with glutathione precursor decreases cytokine activity. JPEN J Parenter Enteral Nutr. 1999;23:1–6
  56. Perez del Pulgar S, Pizcueta P, Engel P, Bosch J. Enhanced monocyte activation and hepatotoxicity in response to endotoxin in portal hypertension. J Hepatol. 2000;32:25–31
  57. Robinson GM, Orrego H, Israel Y, Devenyi P, Kapur BM. Low-molecular-weight polyethylene glycol as a probe of gastrointestinal permeability after alcohol ingestion. Dig Dis Sci. 1981;26:971–977
  58. Sakurai Y, Zhang X-J, Wolfe RR. Effect of tumor necrosis factor on substrate and amino acid kinetics in conscious dogs. Am J Physiol. 1994;266:E936–E945
  59. Saliola M, Lorenzet R, Ferro D, Basili S, Caroselli C, Santo AD, et al. Enhanced expression of monocyte tissue factor in patients with liver cirrhosis. Gut. 1998;43:428–432
  60. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ, et al. Multiple cytokines and acute inflammation raise mouse leptin levels (potential role in inflammatory anorexia). J Exp Med. 1997;185:171–175
  61. Sato M, Miyazaki T, Nagaya T, Murata Y, Ida N, Maeda K, et al. Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells. J Rheumatol. 1996;23:432–438
  62. Sheron N, Bird G, Koskinas J, Portmann B, Ceska M, Lindley I, et al. Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology. 1993;18:41–46
  63. Situnayake RD, Crump BJ, Thurnham DI, Davies JA, Gearty J, Davis M. Lipid peroxidation and hepatic antioxidants in alcoholic liver disease. Gut. 1990;31:1311–1317
  64. Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraeeser L, Alarcon WH, et al. Kupffer cell activation by lipopolysaccharide in rats (role for lipopolysaccharide binding protein and toll-like receptor 4). Hepatology. 2000;31:932–936
  65. Su GL, Rahemtulla A, Thomas P, Klein RD, Wang SC, Nanji AA. CD14 and lipopolysaccharide binding protein expression in a rat model of alcoholic liver disease. Am J Pathol. 1998;152:841–849
  66. Suto G, Kiraly A, Tache Y. Interleukin-1β inhibits gastric emptying in rats (mediation through prostaglandin and corticotropin-releasing factor). Gastroenterology. 1994;106:1568–1575
  67. Szabo G, Mandrekar P, Girouard L, Catalano D. Regulation of human monocyte functions by acute ethanol treatment (decreased tumor necrosis factor-alpha, interleukin-1beta, and elevated interleukin-10, and transforming growth factor-beta production). Alcohol Clin Exp Res. 1996;20:900–907
  68. Thanos D, Maniatis T. Nf-κb (a lesson in family values). Cell. 1995;80:529–532
  69. Tran-Thi T-A, Decker K, Baeuerle PA. Differential activation of transcription factors NF-κB and AP-1 in rat liver macrophages. Hepatology. 1995;22:613–619
  70. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology. 2001;34:101–108
  71. Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D, et al. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 1997;186:2051–2056
  72. Yin M, Bradford BU, Wheeler MD, Uesugi T, Froh M, Goyert SM, et al. Reduced early alcohol-induced liver injury in CD14-deficient mice. J Immunol. 2001;166:4737–4742
  73. Zhang Z, Bagby GJ, Stoltz D, Oliver P, Schwarzenberger PO, Kolls JK. Prolonged ethanol treatment enhances lipopolysaccharide/phorbol myristate acetate–induced tumor necrosis factor-alpha production in human monocytic cells. Alcohol Clin Exp Res. 2001;25:444–449

 Editor: T.R. Jerrells

PII: S0741-8329(02)00212-4

Alcohol
Volume 27, Issue 1 , Pages 53-61 , May 2002