Alcohol
Volume 27, Issue 2 , Pages 115-126 , June 2002

Local cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring (P) rats

  • Daniel G Smith

      Affiliations

    • Program in Psychobiology of Addictions, Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    • Institute of Psychiatric Research, 791 Union Drive, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
  • ,
  • Jennifer E Learn

      Affiliations

    • Program in Medical Neurobiology, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Institute of Psychiatric Research, 791 Union Drive, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
  • ,
  • William J McBride

      Affiliations

    • Institute of Psychiatric Research, 791 Union Drive, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Biochemistry , Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-317-274-3820; fax: +1-317-274-1365
  • ,
  • Lawrence Lumeng

      Affiliations

    • Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Biochemistry , Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • VA Medical Center, Indianapolis, IN 46202-4887, USA
  • ,
  • Ting-Kai Li

      Affiliations

    • Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Biochemistry , Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
  • ,
  • James M Murphy

      Affiliations

    • Program in Psychobiology of Addictions, Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    • Institute of Psychiatric Research, 791 Union Drive, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA
    • Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4887, USA

Received 9 October 2001 ,Revised 1 March 2002 ,Accepted 9 March 2002.

References 

  1. Azmitia EC, Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurology. 1978;179:641–667
  2. Bare DJ, McKinzie JH, McBride WJ. Development of rapid tolerance to ethanol-stimulated serotonin release in the ventral hippocampus. Alcohol Clin Exp Res. 1998;22:1272–1276
  3. Begleiter H, Porjesz B. What is inherited in the predisposition toward alcoholism? A proposed model. Alcohol Clin Exp Res. 1999;23:1125–1135
  4. Bloom FE, Siggins GR. Electrophysiological action of ethanol at the cellular level. Alcohol. 1987;4:331–337
  5. Cicero TJ. A critique of animal analogues of alcoholism. In:  Majchrowicz E,  Noble E editor. Biochemistry and Pharmacology of Alcohol. New York: Plenum Press; 1979;p. 533–560
  6. Crane AM, Porrino LJ. Adaptation of the quantitative 2-[14C]deoxyglucose method for use in freely moving rats. Brain Res. 1989;499:87–92
  7. Gatto GJ, McBride WJ, Murphy JM, Lumeng L, Li T-K. Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats. Alcohol. 1994;11:557–564
  8. Grupp LA. Biphasic action of ethanol on single units of the dorsal hippocampus and the relationship to the cortical EEG. Psychopharmacology (Berl). 1980;70:95–103
  9. Hyytia P, Koob GF. GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol. 1995;283:151–159
  10. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  11. Kadekaro M, Savaki HE, Kutyna FA, Davidsen L, Sokoloff L. Metabolic mapping in the sympathetic ganglia and brain of the spontaneously hypertensive rat. J Cereb Blood Flow Metab. 1983;3:460–467
  12. Katner SN, Magalong JG, Weiss F. Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat. Neuropsychopharmacology. 1999;20:471–479
  13. Katner SN, Weiss F. Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens. Alcohol Clin Exp Res. 1999;23:1751–1760
  14. Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science. 1988;242:715–723
  15. Koob GF, Roberts AJ, Schulteis G, Parsons LH, Heyser CJ, Hyytia P, et al. Neurocircuitry targets in ethanol reward and dependence. Alcohol Clin Exp Res. 1998;22:3–9
  16. Kurumaji A, Dewar D, McCulloch J. Metabolic mapping with deoxyglucose autoradiography as an approach for assessing drug action in the central nervous system. In:  London ED editors. Imaging Drug Action in the Brain. Boca Raton: CRC Press; 1993;p. 207–263
  17. Lankford MF, Roscoe AK, Pennington SN, Myers RD. Drinking of high concentrations of ethanol versus palatable fluids in alcohol-preferring (P) rats (valid animal model of alcoholism). Alcohol. 1991;8:293–299
  18. Le AD, Poulos CX, Harding S, Watchus J, Juzytsch W, Shaham Y. Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology. 1999;21:435–444
  19. LeMarquand D, Pihl RO, Benkelfat C. Serotonin and alcohol intake, abuse, and dependence (findings of animal studies). Biol Psychiatry. 1994;36:395–421
  20. Lyons D, Whitlow CT, Smith HR, Porrino LJ. Brain imaging. Functional consequences of ethanol in the central nervous system. Recent Dev Alcohol. 1998;14:253–284
  21. McBride WJ, Li T-K. Animal models of alcoholism (neurobiology of high alcohol-drinking behavior in rodents). Crit Rev Neurobiol. 1998;12:339–369
  22. McKinzie DL, Nowak KL, Yorger L, McBride WJ, Murphy JM, Lumeng L, et al. The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions. Alcohol Clin Exp Res. 1998;22:1170–1176
  23. McMillen BA. Toward a definition of a valid model of alcoholism (multiple animal models for multiple diseases). Alcohol. 1997;14:409–419
  24. Murphy JM, Gatto GJ, McBride WJ, Lumeng L, Li T-K. Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. Alcohol. 1989;6:127–131
  25. Murphy JM, Gatto GJ, Waller MB, McBride WJ, Lumeng L, Li T-K. Effects of scheduled access on ethanol intake by the alcohol-preferring (P) line of rats. Alcohol. 1986;3:331–336
  26. Murphy JM, Waller MB, Gatto GJ, McBride WJ, Lumeng L, Li T-K. Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats. Alcohol. 1988;5:283–286
  27. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed. New York: Academic Press; 1986;
  28. Porrino LJ, Whitlow CT, Samson HH. Effects of the self-administration of ethanol and ethanol/sucrose on rates of local cerebral glucose utilization in rats. Brain Res. 1998;791:18–26a
  29. Porrino LJ, Williams-Hemby L, Whitlow C, Bowen C, Samson HH. Metabolic mapping of the effects of oral alcohol self-administration in rats. Alcohol Clin Exp Res. 1998;22:176–182b
  30. Rodd-Henricks ZA, McKinzie DL, Edmundson VE, Dagon CL, Murphy JM, McBride WJ, et al. Effects of 5-HT3 receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol. 2000;21:73–85
  31. Schwartz WJ, Smith CB, Davidsen L, Savaki H, Sokoloff L, Mata M, et al. Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science. 1979;205:723–725
  32. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. Alcohol-naive alcohol-preferring (P) rats exhibit higher local cerebral glucose utilization than alcohol-nonpreferring (NP) and Wistar rats. Alcohol Clin Exp Res. 2001;25:1309–1316a
  33. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring rats. Pharmacol Biochem Behav. 2001;69:543–553b
  34. Sokoloff L. Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc. 1981;40:2311–2316
  35. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization (theory, procedure, and normal values in the conscious and anesthetized albino rat). J Neurochem. 1977;28:897–916
  36. Waller MB, McBride WJ, Gatto GJ, Lumeng L, Li T-K. Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. Science. 1984;225:78–80
  37. Waller MB, McBride WJ, Lumeng L, Li T-K. Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats. Pharmacol Biochem Behav. 1982;16:501–507
  38. Williams-Hemby L, Grant KA, Gatto GJ, Porrino LJ. Metabolic mapping of the effects of chronic voluntary ethanol consumption in rats. Pharmacol Biochem Behav. 1996;54:415–423
  39. Williams-Hemby L, Porrino LJ. Low and moderate doses of ethanol produce distinct patterns of cerebral metabolic changes in rats. Alcohol Clin Exp Res. 1994;18:982–988
  40. Williams-Hemby L, Porrino LJ. I. Functional consequences of intragastrically administered ethanol in rats as measured by the 2-[14C]deoxyglucose method. Alcohol Clin Exp Res. 1997;21:1573–1580
  41. Wise RA. Action of drugs of abuse on brain reward systems. Pharmacol Biochem Behav. 1980;13(Suppl 1):213–223

 E-mail address: wmcbride@iupui.edu (W.J. McBride).

☆☆ Editor: T.R. Jerrells.

PII: S0741-8329(02)00216-1

Alcohol
Volume 27, Issue 2 , Pages 115-126 , June 2002