Alcohol
Volume 27, Issue 3 , Pages 185-192 , July 2002

S-Adenosylmethionine, cytokines, and alcoholic liver disease

  • Craig J McClain

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, University of Louisville Medical Center, 550 S. Jackson St., ACB 3rd Floor, Louisville, KY 40292, USA. Tel.: +1-502-852-6991; fax: +1-502-852-0846.
    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    • Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40292, USA
    • Veterans Administration, Louisville, KY 40292, USA
    • ,
  • Daniell B Hill

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    • Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40292, USA
    • ,
  • Zhenyuan Song

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    • ,
  • Rajender Chawla
    • ,
  • Walter H Watson

      Affiliations

    • Department of Biochemistry, Emory University, Atlanta, GA 30322, USA
    • ,
  • Theresa Chen

      Affiliations

    • Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40292, USA
    • ,
  • Shirish Barve

      Affiliations

    • Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    • Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40292, USA

Received 11 February 2002 ,Revised 18 April 2002 ,Accepted 19 April 2002.

References 

  1. Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology. 1995;108:218–224
  2. Alix JH. Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine. Microbiol Rev. 1982;46:281–295
  3. Bhagwandeen BS, Apte M, Manwarring L, Dickeson J. Endotoxin induced hepatic necrosis in rats on an alcohol diet. J Pathol. 1987;152:47–53
  4. Blazka ME, Elwell MR, Holladay SD, Wilson RE, Luster MI. Histopathology of acetaminophen-induced liver changes (role of interleukin 1 alpha and tumor necrosis factor alpha). Toxicol Pathol. 1996;24:181–189
  5. Bradham CA, Plumpe J, Manns MP, Brenner DA, Trautwein C. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol. 1998;275:G387–G392
  6. Bray GP, Tredger JM, Williams R. S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models. Hepatology. 1992;15:297–301
  7. Cabrero C, Martı́n-Duce A, Ortiz P, Alemany S, Mato JM. Specific loss of the high-molecular-weight form of S-adenosyl-l-methionine synthetase in human liver cirrhosis. Hepatology. 1988;8:1530–1534
  8. Cantoni GL. Biological methylation (selected aspects). Annu Rev Biochem. 1975;44:435–451
  9. Chawla RK, Lewis FW, Kutner MH, Bate DM, Roy RG, Rudman D. Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroenterology. 1984;87:770–776
  10. Chawla RK, Watson WH, Eastin CE, Lee EY, Schmidt J, McClain CJ. S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury. Am J Physiol. 1998;275:G125–G129
  11. Chawla RK, Wolf DC, Kutner MH, Bonkovsky HL. Choline may be an essential nutrient in malnourished patients with cirrhosis. Gastroenterology. 1989;97:1514–1520
  12. Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, et al. S-Adenosylmethionine and methylation. FASEB J. 1996;10:471–480
  13. Clarke CJP, Hales A, Hunt A, Foxwell BMJ. IL-10- mediated suppression of TNF-α production is independent of its ability to inhibit NFκB activity. Eur J Immunol. 1998;28:1719–1726
  14. Corrales F, Gimenez A, Alvarez L, Caballeria J, Pajares MA, Andreu H, et al. S-adenosylmethionine treatment prevents carbon tetrachloride–induced S-adenosylmethionone synthetase inactivation and attenuates liver injury. Hepatology. 1992;16:1022–1027
  15. Diehl AM. Cytokine regulation of liver injury and repair. Immunol Rev. 2000;174:160–171
  16. Eastin CE, McClain CJ, Lee EY, Bagby GJ, Chawla RK. Choline deficiency augments and antibody to tumor necrosis factor-alpha attenuates endotoxin-induced hepatic injury. Alcohol Clin Exp Res. 1997;21:1037–1041
  17. Garcia-Trevijano ER, Latasa MU, Carretero MV, Berasain C, Mato JM, Avila MA. S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes (a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver). FASEB J. 2000;14:2511–2518
  18. Grove J, Daly AK, Bassendine MF, Day CP. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology. 1997;26:143–146
  19. Hambleton J, Weinstein SL, Lem L, DeFranco AL. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide–stimulated macrophages. Proc Natl Acad Sci USA. 1996;93:2774–2778
  20. Han J, Huez G, Beutler B. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J Immunol. 1991;146:1843–1848
  21. Hill D, Shedlofsky S, McClain C, Diehl AM, Tsukamoto H. Cytokines and liver disease. In:  Remick DG,  Friedland JS editor. Cytokines in Health and Disease. 2nd ed. New York: Marcel Dekker; 1997;p. 401–425
  22. Hill DB, Deaciuc IV, Nanji AA, McClain CJ. Mechanisms of hepatic injury in alcoholic liver disease. Clin Liver Dis. 1998;2:703–721
  23. Hill DB, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. J Lab Clin Med. 1992;119:547–552
  24. Hill DB, Marsano LS, McClain CJ. Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology. 1993;18:576–580
  25. Honchel R, Ray MB, Marsano L, Cohen D, Lee E, Shedlofsky S, et al. Tumor necrosis factor in alcohol enhanced endotoxin liver injury. Alcohol Clin Exp Res. 1992;16:665–669
  26. Horowitz JH, Rypins EB, Henderson JM, Heymsfield SB, Moffitt SD, Bain RP, et al. Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology. 1981;81:668–675
  27. Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology. 1997;26:1530–1537
  28. Kamimura S, Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology. 1995;22:1304–1309
  29. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology. 1991;13:267–276
  30. Kruys V, Thompson P, Beutler B. Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway. J Exp Med. 1993;177:1383–1390
  31. Le Moine O, Marchant A, De Groote D, Azar C, Goldman M, Devière J. Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholics cirrhosis. Hepatology. 1995;22:1436–1439
  32. Lieber CS, Casini A, DeCarli LM, Kim CI, Lowe N, Sasaki R, et al. S-adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology. 1990;11:165–172
  33. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA. 2001;98:5560–5565
  34. Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G178–G185
  35. Martı́n-Duce A, Ortiz P, Carbrero C, Mato JM. S-adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology. 1988;8:65–68
  36. Mato JM, Alvarez L, Corrales FJ, Pajares MA. S-adenosylmethionine and the liver. In:  Arias IM,  Boyer JL,  Fausto N,  Jakoby WB,  Schachter DA,  Shafritz DA editor. The Liver (Biology and Pathobiology). 3rd ed. New York: Raven Press; 1994;p. 461–470
  37. Mato JM, Alvarez L, Ortiz P, Pajares MA. S-adenosylmethionine synthesis (molecular mechanisms and clinical implications). Pharmacol Ther. 1997;73:265–280
  38. McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis. 1993;13:170–182
  39. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis. 1999;19:205–219
  40. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349–351
  41. Nanji AA, Khettry U, Sadrzadeh SM. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med. 1994;205:243–247 a
  42. Nanji AA, Miao L, Thomas P, Rahemtulla A, Khwaja S, Zhao S, et al. Enhanced cyclooxgenase-2 gene expression in alcoholic liver disease in the rat. Gastroenterology. 1997;112:943–951
  43. Nanji AA, Zhao S, Sadrzadeh SM, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. Alcohol Clin Exp Res. 1994;18:1280–1285 b
  44. Nanji AA, Zhao S, Sadrzadeh SM, Waxman DJ. Use of reverse transcription-polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods. Hepatology. 1994;19:1483–1487 c
  45. Odeh M. Endotoxin and tumor necrosis factor-alpha in the pathogenesis of hepatic encephalopathy. J Clin Gastroenterol. 1994;19:146–153
  46. Rennick DM, Fort MM. Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10−/−) mice and intestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2000;278:G829–G833
  47. Schenker S, Bay MK. Alcohol and endotoxin (another path to alcoholic liver injury?). Alcohol Clin Exp Res. 1995;19:1364–1366
  48. Schuppan D, Hahn EG. Interleukin 10 (the magic bullet for liver fibrosis?). Gastroenterology. 2000;119:1412–1414
  49. Stipanuk MH. Metabolism of sulfur-containing amino acids. Annu Rev Nutr. 1986;6:179–209
  50. Varela-Moreiras G, Alonso-Aperte E, Rubio M, Gasso M, Deulofeu R, Alvarez L, et al. Carbon tetrachloride–induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia (effect of S-adenosylmethionine treatment). Hepatology. 1995;22:1310–1315
  51. Wanidworanun C, Strober W. Predominant role of tumor necrosis factor-α in human monocyte IL-10 synthesis. J Immunol. 1993;151:6853–6861
  52. Weinstein SL, Gold MR, DeFranco AL. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci USA. 1991;88:4148–4152
  53. Zheng ZM, Specter S. Dynamic production of tumour necrosis factor-α (TNF-α) messenger RNA, intracellular and extracellular TNF-α by murine macrophages and possible association with protein tyrosine phosphorylation of STAT1 α and ERK2 as an early signal. Immunology. 1996;87:544–550

☆ Editor: T.R. Jerrells

PII: S0741-8329(02)00224-0

Alcohol
Volume 27, Issue 3 , Pages 185-192 , July 2002

Article Tools

* Image Usage & Resolution