Alcohol
Volume 27, Issue 3 , Pages 169-172 , July 2002

Folate deficiency, methionine metabolism, and alcoholic liver disease

  • Charles H Halsted

      Affiliations

    • Corresponding Author InformationCorresponding author. Division of Clinical Nutrition, TB156, School of Medicine, One Shields Avenue, University of California, Davis, Davis, CA 95616, USA. Tel.: +1-530-752-6778; fax: +1-530-752-3470.
    • ,
  • Jesus A Villanueva
    • ,
  • Angela M Devlin

Received 4 February 2002 ,Revised 22 March 2002 ,Accepted 22 March 2002.

References 

  1. Avila MA, Corrales FJ, Ruiz F, Sanchez-Gongora E, Mingorance J, Carretero MV, et al. Specific interaction of methionine adenosyltransferase with free radicals. Biofactors. 1998;8:27–32
  2. Barak AJ, Beckenhauer HC, Tuma DJ, Badakhsh S. Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol. 1987;65:230–233
  3. Chern CL, Huang RF, Chen YH, Cheng JT, Liu TZ. Folate deficiency–induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells. Biomed Pharmacother. 2001;55:434–442
  4. Colell A, Garcı́a-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodés J, et al. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats (effect of membrane physical properties and S-adenosyl-l-methionine). Hepatology. 1997;26:699–708
  5. Corrales F, Ochoa P, Rivas C, Martin-Lomas M, Mato JM, Pajares MA. Inhibition of glutathione synthesis in the liver leads to S-adenosyl-l-methionine synthetase reduction. Hepatology. 1991;14:528–533
  6. Eichner ER, Hillman RS. The evolution of anemia in alcoholic patients. Am J Med. 1971;50:218–232
  7. Finkelstein JD, Cello JP, Kyle WE. Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res Commun. 1974;61:525–531
  8. Halsted CH, Robles EA, Mezey E. Decreased jejunal uptake of labeled folic acid (3 H-PGA) in alcoholic patients (roles of alcohol and nutrition). N Engl J Med. 1971;285:701–706
  9. Halsted CH, Villanueva J, Chandler CJ, Ruebner B, Munn RJ, Parkkila S, et al. Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology. 1993;18:954–960
  10. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, et al. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 1996;23:497–505
  11. Herbert V, Zalusky R, Davidson CS. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia, and liver disease. Ann Intern Med. 1963;58:977–988
  12. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  13. James SJ, Miller BJ, Basnakian AG, Pogribny IP, Pogribna M, Muskhelishvili L. Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats. Carcinogenesis. 1997;18:287–293
  14. Jokelainen K, Reinke LA, Nanji AA. Nf-kappab activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver disease. Cytokine. 2001;16:36–39
  15. Leevy CM, Cardi L, Frank O, Gellene R, Baker H. Incidence and significance of hypovitaminemia in a randomly selected municipal hospital population. Am J Clin Nutr. 1965;17:259–271
  16. Lieber CS. Medical disorders of alcoholism. N Engl J Med. 1995;333:1058–1065
  17. Lieber CS, Casini A, DeCarli LM, Kim CI, Lowe N, Sasaki R, et al. S-adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology. 1990;11:165–172
  18. Lu SC. Methionine adenosyltransferase and liver disease (it's all about SAM). Gastroenterology. 1998;114:403–407 [editorial; comment]
  19. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A. 2001;98:5560–5565
  20. Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G178–G185
  21. Mato JM, Alvarez L, Ortiz P, Mingorance J, Durán C, Pajares MA. S-adenosyl-l-methionine synthetase and methionine metabolism deficiencies in cirrhosis. Adv Exp Med Biol. 1994;368:113–117
  22. Mato JM, Camara J, Fernandez de Paz J, Caballeria L, Coll S, Caballero A, et al. S-adenosylmethionine in alcoholic liver cirrhosis (a randomized, placebo-controlled, double-blind, multicenter clinical trial). J Hepatol. 1999;30:1081–1089
  23. McMartin KE, Collins TD, Eisenga BH, Fortney T, Bates WR, Bairnsfather L. Effects of chronic ethanol and diet treatment on urinary folate excretion and development of folate deficiency in the rat. J Nutr. 1989;119:1490–1497
  24. Nanji AA, Jokelainen K, Rahemtulla A, Miao L, Fogt F, Matsumoto H, et al. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology. 1999;30:934–943
  25. Niemela O, Parkkila S, Pasanen M, Viitala K, Villanueva JA, Halsted CH. Induction of cytochrome P450 enzymes and generation of protein–aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs. Hepatology. 1999;30:1011–1017
  26. Niemela O, Parkkila S, Yla-Herttuala S, Villanueva J, Ruebner B, Halsted CH. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology. 1995;22:1208–1214
  27. Romero JJ, Tamura T, Halsted CH. Intestinal absorption of [3H]folic acid in the chronic alcoholic monkey. Gastroenterology. 1981;80:99–102
  28. Russell RM, Rosenberg IH, Wilson PD, Iber FL, Oaks EB, Giovetti AC, et al. Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion. Am J Clin Nutr. 1983;38:64–70
  29. Subcommittee on Swine Nutrition, Committee on Animal Nutrition, National Research Council . Nutrient Requirements of Swine (10th Revised Edition). Washington, DC: Board on Agriculture and Natural Resources; 1998;
  30. Tamura T, Halsted CH. Folate turnover in chronically alcoholic monkeys. J Lab Clin Med. 1983;101:623–628
  31. Tamura T, Romero JJ, Watson JE, Gong EJ, Halsted CH. Hepatic folate metabolism in the chronic alcoholic monkey. J Lab Clin Med. 1981;97:654–661
  32. Trimble KC, Molloy AM, Scott JM, Weir DG. The effect of ethanol on one-carbon metabolism (increased methionine catabolism and lipotrope methyl-group wastage). Hepatology. 1993;18:984–989
  33. Tsukamoto H, Lu SC. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J. 2001;15:1335–1349
  34. Wu A, Chanarin I, Slavin G, Levi AJ. Folate deficiency in the alcoholic—its relationship to clinical and haematological abnormalities, liver disease and folate stores. Br J Haematol. 1975;29:469–478

☆ Editor: T.R. Jerrells

PII: S0741-8329(02)00225-2

Alcohol
Volume 27, Issue 3 , Pages 169-172 , July 2002

Article Tools