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Alcohol
Volume 27, Issue 3
, Pages 155-162
, July 2002
Role of abnormal methionine metabolism in alcoholic liver injury
References
- . Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology. 1995;108:218–224
-
.
Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase (tissue-specific gene expression and mRNA levels in hepatopathies).
Biochem J. 1993;293:481–486
- . Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol. 2000;33:907–914
- . Regulation of rat liver S-adenosylmethionine synthetase during septic shock (role of nitric oxide). Hepatology. 1997;25:391–396
- . Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res. 1993;17:552–555
- . Alterations in DNA methylation (a fundamental aspect of neoplasia). Adv Cancer Res. 1998;72:141–196
- . ERK2 activation by homocysteine in vascular smooth muscle cells. Biochem Biophys Res Commun. 1998;251:669–676
- . Specific loss of the high-molecular-weight form of S-adenosyl-l-methionine synthetase in human liver cirrhosis. Hepatology. 1988;8:1530–1534
- . Purification and comparison of two forms of S-adenoysl-l-methionine synthetase from rat liver. Eur J Biochem. 1987;170:299–304
- . Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res. 1998;58:1444–1450
- . Changes in S-adenosylmethionine synthetase in human liver cancer (molecular characterization and significance). Hepatology. 1996;24:1090–1097
- . S-adenosylmethionine deficiency and TNF-α in lipopolysaccharide-induced hepatic injury. Am J Physiol. 1998;275:G125–G129
- . Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine (methionine loading of non-transformed, transformed, proliferating, and quiescent cells in culture). J Cell Physiol. 1991;146:52–62
- . Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats (effect of membrane physical properties and S-adenosyl-l-methionine). Hepatology. 1997;26:699–708
- . S-adenosylmethionine treatment prevents carbon tetrachloride–induced S-adenosylmethionine synthetase inactivation and attenuates liver injury. Hepatology. 1992;16:1022–1027
- . Inhibition of glutathione synthesis in the liver leads to S-adenoysl-l-methionine synthetase reduction. Hepatology. 1991;14:528–533
- . Hyperhomocysteinemia in chronic alcoholism (correlation with folate, vitamin B-12, and vitamin B-6 status). Am J Clin Nutr. 1996;63:220–224
- . Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228–237
- . Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res Commun. 1974;61:525–531
- . Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J Biol Chem. 1984;259:9508–9513
- . Methionine metabolism in mammals. Adaptation to methionine excess. J Biol Chem. 1986;261:1582–1587
- . Ethanol-induced hepatic fibrosis in the rat (role of the amount of dietary fat). Alcohol Clin Exp Res. 1986;10:13S–19S
- . Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 1993;328:1828–1835
- . Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride–induced cirrhosis. J Hepatol. 1996;25:200–205
- . Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development. Hepatology. 1996;24:876–881
- . Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells. J Biol Chem. 1999;274:29720–29725
- . Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 1996;23:497–505
- . S-Adenosylmethionine and S-adenosylhomocysteine metabolism in isolated rat liver. Effects of l-methionine, l-homocysteine, and adenosine. J Biol Chem. 1980;255:10822–10827
- . Immunohistochemical analysis of rat S-adenosylmethionine synthetase isozymes in developmental liver. FEBS Lett. 1993;330:307–311
- . Molecular cloning and developmental expression of a human kidney S-adenosylmethionine synthetase. FEBS Lett. 1992;312:37–41
- . Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology. 1981;81:668–675
- . Changes in methionine adenosyltransferase during liver regeneration in the rat. Am J Physiol. 1998;275:G14–G21
- . Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. Hepatology. 1999;29:1471–1478
- . Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res. 1993;17:687–689
- . Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology. 1997;26:1530–1537
- . Increased 4-hydroxynonenal levels in experimental alcoholic liver disease (association of lipid peroxidation with liver fibrogenesis). Hepatology. 1992;16:448–453
-
.
Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage.
Science. 1947;106:589–594
- . S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization. J Biol Chem. 1985;260:3923–3930
- . Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products. Trends Genet. 1997;13:51–52
- . Cloning, expression, and functional characterization of the β regulatory subunit of human methionine adenosyltransferase (MAT II). J Biol Chem. 2000;275:2359–2366
- . Homocysteine and vascular dysfunction. Life Sci. 1997;61:1205–1215
- . Correlation of isozyme patterns of S-adenosylmethionine synthetase with fetal stages and pathologic states of the liver. Cancer Res. 1979;39:162–169
- . S-adenoysl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology. 1990;11:165–172
- . Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin Exp Res. 1994;18:592–595
- . Regulation of hepatic glutathione synthesis. Semin Liver Dis. 1998;18:331–343
-
.
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Proc Natl Acad Sci USA. 2001;98:5560–5565
- . Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G178–G185
- . Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997;17:2074–2081
- . S-adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology. 1988;8:65–68
-
.
S-adenosylmethionine and the liver.
In:
Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA editor. The Liver (Biology and Pathobiology). 3rd ed. New York: Raven Press; 1994;p. 461–470
- . S-adenosylmethionine synthesis (molecular mechanisms and clinical implications). Pharmacol Ther. 1997;73:265–280
- . S-adenosylmethionine in alcoholic liver cirrhosis (a randomized, placebo-controlled, double-blind, multicenter clinical trial). J Hepatol. 1999;30:1081–1089
-
.
Site-directed mutagenesis of rat liver S-adenosylmethionine synthetase. Identification of a cysteine residue critical for the oligomeric state.
Biochem J. 1996;315:761–766
-
.
Disorders of transsulfuration.
In:
Scriver CR, Beaudet AL, Sly WS, Velle D editor. The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill; 1995;p. 693–734
- . Effect of type of dietary fat and ethanol on antioxidant enzyme mRNA induction in rat liver. J Lipid Res. 1995;36:736–744 a
- . Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease (relationship to endotoxemia and TNF alpha messenger RNA). Exp Mol Pathol. 1995;62:42–51 b
- . In vitro inactivation of mammalian methionine synthase by nitric oxide. Eur J Clin Invest. 1996;26:167–170
- . Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization. Biochemistry. 1981;20:934–940
- . Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione. J Biol Chem. 1992;267:17598–17605
-
Pascale, R. M., Marras, V., Simile, M. M., Daino, L., Pinna, G., Bennati, S., Carta, M., Seddaiu, M. A., Massarelli, G., & Feo, F. (1992). Chemoprevention of rat liver carcinogenesis by S-adenoysl-l-methionine: a long-term study. Cancer Res 52, 4979–4986.
- . Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res. 1995;55:1894–1901
- . Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31–62
- . Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation. Hepatology. 1998;28:1051–1057
- . Interaction of liver methionine adenosyltransferase with hydroxyl radical. FASEB J. 1997;11:1013–1019
- . Alcohol and endotoxin (another path to alcoholic liver injury?). Alcohol Clin Exp Res. 1995;19:1364–1366
- . Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693–2698
- . The pathogenesis of homocysteinemia (interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine). Am J Clin Nutr. 1992;55:131–138
- . Differential expression of S-adenosylmethionine synthetase isozymes in different cell types of rat liver. Hepatology. 1997;26:424–431
- . Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91:308–318
- . Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res. 2000;24:259–264
- . Fractionation and kinetic properties of rat liver and kidney methionine adenosyltransferase isozymes. Biochemistry. 1983;22:1636–1641
- . The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscle. Atherosclerosis. 1998;136:169–173
- . Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes (a new role for homocysteine in liver fibrosis). Biochim Biophys Acta. 1999;1455:12–22
- . The effect of ethanol on one-carbon metabolism (increased methionine catabolism and lipotrope methyl-group wastage). Hepatology. 1993;18:984–989
-
.
Promotion of vascular smooth muscle cell growth by homocysteine (a link to atherosclerosis).
Proc Natl Acad Sci USA. 1994;91:6369–6373
- . Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest. 1996;97:146–153
- . Insights into the pathogenesis of alcoholic liver necrosis and fibrosis (status report). Hepatology. 1990;12:599–608
- . Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology. 1986;6:814–822
- . Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells. Am J Physiol. 1998;274:C396–C405
- . Carbon tetrachloride–induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia (effect of S-adenosylmethionine treatment). Hepatology. 1995;22:1310–1315
- . Effects of oral S-adenoysl-l-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989;24:407–415
- . S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha. Biochem J. 1999;342:21–25
☆ Editor: T.R. Jerrells
PII: S0741-8329(02)00226-4
© 2002 Elsevier Science Inc. All rights reserved.
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Alcohol
Volume 27, Issue 3
, Pages 155-162
, July 2002
