Alcohol
Volume 27, Issue 3 , Pages 193-198 , July 2002

Chemoprevention of hepatocarcinogenesis: S-adenosyl-l-methionine

Received 4 February 2002 ,Revised 30 March 2002 ,Accepted 2 April 2002.

References 

  1. Cai J, Mao Z, Hwang JJ, Lu SC. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res. 1998;58:1444–1450
  2. Cai J, Sun WM, Hwang JJ, Stain SC, Lu SC. Changes in S-adenosylmethionine synthetase in human liver cancer (molecular characterization and significance). Hepatology. 1996;24:1090–1097
  3. Coni P, Pang J, Pichiri-Coni G, Hsu S, Rao PM, Rajalakshmi S, et al. Hypomethylation of β-hydroxy-β-methyl-glutaryl CoA reductase gene and its expression during hepatocarcinogenesis in the rat. Carcinogenesis. 1992;13:497–499
  4. De Flora S, Izzotti A, D'Agostini F, Balansky RM. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis. 2001;22:999–1013
  5. De Miglio MR, Simile MM, Muroni MR, Pusceddu S, Calvisi D, Carru A, et al. Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain. Mol Carcinog. 1999;25:21–29
  6. Enomoto K, Farber E. Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis. Cancer Res. 1982;42:2330–2335
  7. Feo F, Garcea R, Daino L, Pascale R, Pirisi L, Frassetto S, et al. Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-l-methionine cellular pool. Carcinogenesis. 1985;6:1713–1720
  8. Feo F, Garcea R, Pascale R, Pirisi L, Daino L, Donaera A. The variations in S-adenosyl-l-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis. Toxicol Pathol. 1987;15:109–114
  9. Feo F, Pascale RM, Simile MM, De Miglio MR, Muroni MR, Calvisi D. Genetic alterations in liver carcinogenesis (implications for new preventive and therapeutic strategies). Crit Rev Oncog. 2000;11:19–62
  10. Garcea R, Daino L, Pascale R, Simile MM, Puddu M, Frassetto S, et al. Inhibition of promotion and persistent nodule growth by S-adenosyl-l-methionine in rat liver carcinogenesis (role of remodeling and apoptosis). Cancer Res. 1989;49:1850–1856 a
  11. Garcea R, Daino L, Pascale R, Simile MM, Puddu M, Ruggiu ME, et al. Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine (effect of variations of S-adenosylmethionine: S-adenosylhomocysteine ratio). Carcinogenesis. 1989;10:1183–1192 b
  12. Garcea R, Pascale R, Daino L, Frassetto S, Cozzolino P, Ruggiu ME, et al. Variations of ornithine decarboxylase activity and S-adenosyl-l-methionine and 5′-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma. Carcinogenesis. 1987;8:653–658
  13. Ghoshal AK, Farber E. The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis. 1984;5:1367–1370
  14. Gil B, Casado M, Pajares MA, Boscá L, Mato JM, Martin-Sanz P, et al. Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development. Hepatology. 1996;24:876–881
  15. Lombardi B. The choline-devoid diet model or hepatocarcinogenesis in the rat. In:  Feo F,  Pani P,  Columbano A,  Garcea R editor. Chemical Carcinogenesis. Models and Mechanisms. New York: Plenum; 1988;p. 563–581
  16. Pascale RM, De Miglio MR, Muroni MR, Simile MM, Daino L, Seddaiu MA, et al. c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model. Int J Cancer. 1996;68:136–142
  17. Pascale RM, De Miglio MR, Muroni MR, Simile MM, Daino L, Seddaiu MA, et al. Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat. Hepatology. 1998;27:452–461
  18. Pascale RM, Marras V, Simile MM, Daino L, Pinna G, Bennati S, et al. Chemoprevention of rat liver carcinogenesis by S-adenosyl-l-methionine (a long-term study). Cancer Res. 1992;52:4979–4986
  19. Pascale RM, Simile MM, De Miglio MR, Nufris A, Daino L, Seddaiu MA, et al. Chemoprevention by S-adenosyl-l-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Carcinogenesis. 1995;16:427–430
  20. Pascale RM, Simile MM, Feo F. Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. Anticancer Res. 1993;13:1341–1356 a
  21. Pascale RM, Simile MM, Gaspa L, Daino L, Seddaiu MA, Pinna G, et al. Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis. Carcinogenesis. 1993;14:1077–1080 b
  22. Pascale RM, Simile MM, Ruggiu ME, Seddaiu MA, Satta G, Sequenza MJ, et al. Reversal by. 1991;5-azacytidine(of the S-adenosyl-l-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis. Cancer Lett 56):259–265 a
  23. Pascale RM, Simile MM, Satta G, Seddaiu MA, Daino L, Pinna G, et al. Comparative effects of l-methionine, S-adenosyl-l-methionine and 5′-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis. Anticancer Res. 1991;11:1617–1624 b
  24. Rao PM, Antony A, Rajalakshmi S, Sarma DSR. Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver. Carcinogenesis. 1989;10:933–937
  25. Shen L, Fang J, Qiu D, Zhang T, Yang J, Chen S, et al. Correlation between DNA methylation and pathological changes in human hepatocellular carcinoma. Hepatogastroenterology. 1998;45:1753–1759
  26. Simile MM, Banni S, Angioni E, Carta G, De Miglio MR, Muroni MR, et al. 5′-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication. J Hepatol. 2001;34:386–394
  27. Simile MM, Pascale R, De Miglio MR, Nufris A, Daino L, Seddaiu MA, et al. Correlation between S-adenosyl-l-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis. Cancer Lett. 1994;79:9–16
  28. Simile MM, Saviozzi M, De Miglio MR, Muroni MR, Nufris A, Pascale RM, et al. Persistent chemopreventive effect of S-adenosyl-l-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats. Carcinogenesis. 1996;17:1533–1537
  29. Solt DB, Medline A, Farber E. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol. 1977;88:595–618
  30. Tsukada K, Okada G. S-Adenosylmethionine synthetase isozyme patterns from rat hepatoma induced by N-2-fluorenylacetamide. Biochem Biophys Res Commun. 1980;94:1078–1082
  31. Wainfan E, Poirier LA. Methyl groups in carcinogenesis (effects on DNA methylation and gene expression). Cancer Res. 1992;52:2071s–2077s
  32. Wu SE, Huskey WP, Borchardt RT, Schowen RL. Chiral instability at sulfur of S-adenosylmethione. Biochemistry. 1983;22:2828–2832
  33. Zappia V, Zydek-Cwick R, Schlenk F. The specificity to S-adenosylmethionine derivatives in methyl transfer reactions. J Biol Chem. 1969;244:4499–4509
  34. Zingg J-M, Jones PA. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis. 1997;18:869–882

☆ Editor: T.R. Jerrells

PII: S0741-8329(02)00227-6

Alcohol
Volume 27, Issue 3 , Pages 193-198 , July 2002

Article Tools

* Image Usage & Resolution