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Alcohol
Volume 27, Issue 3
, Pages 163-167
, July 2002
S-Adenosylmethionine revisited: its essential role in the regulation of liver function
References
- . Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol. 2000;33:907–914
- . Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes. Gastroenterology. 1998;114:364–371
- . Regulation of rat liver S-adenosylmethionine synthetase during septic shock (role of nitric oxide). Hepatology. 1997;25:391–396
- . Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol. 1987;65:230–233
- . The leaky gut of alcoholism (a possible route of entry of toxic compounds). Lancet. 1984;1:179–182
- . Specific loss of the high-molecular-weight form of S-adenosyl-l-methionine synthetase in human liver cirrhosis. Hepatology. 1988;8:1530–1534
- . Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res. 1998;58:1444–1450
- . Changes in S-adenosylmethionine synthetase in human liver cancer (molecular characterization and significance). Hepatology. 1996;24:1090–1097
- . Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene (protective effect of S-adenosylmethionine). Biochem Pharmacol. 2001;61:1119–1128
- . Biochemistry and pharmacology of S-adenosyl-l-methionine and rationale for its use in liver disease. Drugs. 1990;40(Suppl 3):98–110
- . S-adenosylmethionine treatment prevents carbon tetrachloride–induced S-adenosylmethionine synthetase inactivation and attenuates liver injury. Hepatology. 1992;16:1022–1027
- . Inhibition of glutathione synthesis in the liver leads to S-adenosyl-l-methionine synthetase reduction. Hepatology. 1991;14:528–533
- . In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver. J Hepatol. 1999;31:887–894
- . Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228–236
-
.
A meta-analysis of therapeutic trials with ademethionine in the treatment of intrahepatic cholestasis.
Ann Ital Med Int. 1993;8(Suppl):48S–51S
- . Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology. 1990;99:211–215
- . Inhibition of promotion and persistent nodule growth by S-adenosyl-l-methionine in rat liver carcinogenesis (role of remodeling and apoptosis). Cancer Res. 1989;49:1850–1856
- . Feeding S-adenosyl-l-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology. 1995;21:207–214
- . S-Adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes (a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver). FASEB J. 2000;14:2511–2518
- . Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development. Hepatology. 1996;24:876–881
- . Amino acid metabolism in liver disease. Curr Opin Clin Nutr Metab Care. 1999;2:47–53
- . Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology. 1981;81:668–675
- . Changes in methionine adenosyltransferase during liver regeneration in the rat. Am J Physiol. 1998;275:G14–G21
-
.
Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage.
Science. 1947;106:589–590
- . Methionine adenosyltransferase (structure and function). Pharmacol Ther. 1993;59:125–143
- . Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products. Trends Genet. 1997;13:51–52
- . Carnitine metabolism in chronic liver disease. Life Sci. 1996;59:1579–1599
- . Decreased carnitine biosynthesis in rats with secondary biliary cirrhosis. Hepatology. 2000;31:1217–1223
- . Hepatocyte growth factor induces MAT2A expression and histone acetylation in rat hepatocytes (role in liver regeneration). FASEB J. 2001;15:1248–1250
- . Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). J Biol Chem. 2000;275:2359–2366
- . Cytochrome P-4502E1 (its physiological and pathological role). Physiol Rev. 1997;77:517–544
- . Prevention and treatment of liver fibrosis based on pathogenesis. Alcohol Clin Exp Res. 1999;23:944–999 a
- . Role of S-adenosyl-l-methionine in the treatment of liver diseases. J Hepatol. 1999;30:1155–1159 b
- . S-adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology. 1990;11:165–172
- . Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin Exp Res. 1994;18:592–595
-
.
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Proc Natl Acad Sci USA. 2001;98:5560–5565
- . Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G178–G185
- . S-Adenosylmethionine modulates inducible nitric oxide synthase gene expression in rat liver and isolated hepatocytes. J Hepatol. 2001;35:692–699
- . Defective methionine metabolism in cirrhosis (relation to severity of liver disease). Hepatology. 1992;16:149–155
- . S-Adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology. 1988;8:65–68
- . S-adenosylmethionine synthesis (molecular mechanisms and clinical implications). Pharmacol Ther. 1997;73:265–280
-
.
Biosynthesis of S-adenosylmethionine.
In:
Carmel R, Jacobsen DW editor. Homocysteine in Health and Disease. Cambridge, UK: Cambridge University Press; 2001;p. 47–62
- . S-adenosylmethionine in alcoholic liver cirrhosis (a randomized, placebo-controlled, double-blind, multicenter clinical trial). J Hepatol. 1999;30:1081–1089
- . Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I. Int J Biochem Cell Biol. 2002;34:242–252
- . Labile methyl balances for normal humans on various dietary regimens. Metabolism. 1975;24:721–735
- . Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. J Nutr. 1997;127:1800–1806
- . Labile methyl groups and the promotion of cancer. Annu Rev Nutr. 1986;6:407–432
- . Chemoprevention of rat liver carcinogenesis by S-adenosyl-l-methionine (a long-term study). Cancer Res. 1992;52:4979–4986
- . Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation. Hepatology. 1998;28:1051–1057
- . Interaction of liver methionine adenosyltransferase with hydroxyl radical. FASEB J. 1997;11:1013–1019
- . Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol. 1988;134:309–323
- . Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation (implications for MAT1A silencing during transformation). FASEB J. 2000;14:95–102
- . The effect of ethanol on one-carbon metabolism (increased methionine catabolism and lipotrope methyl-group wastage). Hepatology. 1993;18:984–989
- . Carbon tetrachloride–induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia (effect of S-adenosylmethionine treatment). Hepatology. 1995;22:1310–1315
- . Effects of oral S-adenosyl-l-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989;24:407–415
- . Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets. Cancer Res. 1989;49:4094–4097
☆ Editor: T.R. Jerrells
PII: S0741-8329(02)00228-8
© 2002 Elsevier Science Inc. All rights reserved.
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Alcohol
Volume 27, Issue 3
, Pages 163-167
, July 2002
