Alcohol
Volume 27, Issue 3 , Pages 173-177 , July 2002

S-Adenosyl-l-methionine and alcoholic liver disease in animal models: implications for early intervention in human beings

  • Charles S Lieber

      Affiliations

    • Corresponding Author InformationCorresponding author. Bronx VA Medical Center (151-2), 130 West Kingsbridge Road, Bronx, NY 10468, USA. Tel.: +1-718-741-4244; fax: +1-718-733-6257.
    • Bronx Veterans Affairs Medical Center, Bronx, NY 10468, USA
    • Mount Sinai School of Medicine, New York, NY 10029, USA

Received 4 February 2002 ,Revised 20 April 2002 ,Accepted 20 April 2002.

References 

  1. Aleynik MK, Leo MA, Aleynik SI, Lieber CS. Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease. Alcohol Clin Exp Res. 1999;23:96–100
  2. Aleynik SI, Leo MA, Aleynik MK, Lieber CS. Polyenylphosphatidylcholine (PPC) corrects the alcohol-induced hepatic oxidative stress by restoring S-adenosyl-l-methionine (SAMe). Alcohol Clin Exp Res. 2001;25(Suppl):131A
  3. Arai M, Gordon ER, Lieber CS. Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids. Biochim Biophys Acta. 1984;797:320–327
  4. Audubert F, Vance DE. Pitfalls and problems in studies on the methylation of phosphatidylethanolamine. J Biol Chem. 1983;258:10695–10701
  5. Barak AJ, Beckenhauer HC, Tuma DJ, Donohue TM. Adaptive increase in betaine-homocysteine methyltransferase activity maintains hepatic S-adenosyl-l-methionine levels in ethanol-treated rats. IRCS Med Sci Biochem. 1984;12:866–867
  6. Bombardieri G, Pappalardo G, Bernardi L, Barra D, Di Palma A, Castrini G. Intestinal absorption of S-adenosyl-l-methionine in humans. Int J Clin Pharmacol Ther Toxicol. 1983;21:186–188
  7. Engstrom MA, Benevenga NJ. Rates of oxidation of the methionine and S-adenosylmethionine methyl carbons in isolated rat hepatocytes. J Nutr. 1987;117:1820–1826
  8. Finkelstein JD, Cello JP, Kyle WE. Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res Commun. 1974;61:525–531
  9. Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J Biol Chem. 1986;261:1582–1587
  10. Fischer JE, Yoshimura N, Aguirre A, James JH, Cummings MG, Abel RM, et al. Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acids infusions. Am J Surg. 1974;127:40–47
  11. Giulidori P, Stramentinoli G. A radioenzymatic method for S-adenosyl-l-methionine determination in biological fluids. Anal Biochem. 1984;137:217–220
  12. Hardwick DF, Applegarth DA, Cockcroft DM, Ross PM, Cder RJ. Pathogenesis of methionine-induced toxicity. Metabolism. 1970;19:381–391
  13. Hoffbauer FW, Zaki FG. Choline deficiency in baboon and rat compared. Arch Pathol. 1965;79:364–369
  14. Hoffman DR, Marion DW, Cornatzer WE, Duerre JA. S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of l-methionine, l-homocystein, and adenosine. J Biol Chem. 1980;255:10822–10827
  15. Horowitz JH, Rypins EB, Henderson JM, Heymsfield SB, Moffitt SD, Bain RP, et al. Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology. 1981;81:668–675
  16. Iber FL, Rosen H, Stanley MA, Levenson SM, Chalmers TC. The plasma amino acids in patients with liver failure. J Lab Clin Med. 1957;50:417–425
  17. Iob V, Coon WW, Sloan M. Free amino acids in liver, plasma, and muscle of patients with cirrhosis of the liver. J Surg Res. 1967;7:41–43
  18. Kinsell LW, Harper HA, Barton HC, Michaels GD, Weiss HA. Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage. Science. 1947;106:589–594
  19. Lieber, C. S. (Ed.). (1992). Medical and Nutritional Complications of Alcoholism: Mechanisms and Management (p. 579). New York: Plenum Press.
  20. Lieber CS. Effect of S-adenosyl-l-methionine (SAMe) and other natural compounds in alcoholic and nonalcoholic liver injury. Prog Hepato-Pharmacol. 1997;11:81–92
  21. Lieber CS, Casini A, DeCarli LM, Kim CI, Lowe N, Sasaki R, et al. S-adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology. 1990;11:165–172 a
  22. Lieber CS, DeCarli LM, Mak KM, Kim CI, Leo MA. Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. Hepatology. 1990;12:1390–1398 b
  23. Lieber CS, Leo MA, Aleynik SI, Aleynik MK, DeCarli LM. Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin Exp Res. 1997;21:375–379
  24. Lieber CS, Robins SJ, Leo MA. Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin Exp Res. 1994;18:592–595 a
  25. Lieber CS, Robins SJ, Li J, DeCarli LM, Mak KM, Fasulo JM, et al. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology. 1994;106:152–159 b
  26. Martin-Duce A, Ortiz P, Cabrero C, Mato JM. S-adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology. 1988;8:65–68
  27. Montanari A, Simoni I, Vallisa D, Trifiro A, Colla R, Abbiati R, et al. Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis. Hepatology. 1988;8:1034–1039
  28. Pezzoli C, Stramentinoli G, Galli-Kienle M, Pfaff E. Uptake and metabolism of S-adenosyl-l-methionine by isolated rat hepatocytes. Biochem Biophys Res Commun. 1978;85:1031–1038
  29. Quiram DR, Weinshilboum RM. Catechol-O-methyltransferase in rat erythrocyte and three other tissues (comparison of biochemical properties after removal of inhibitory calcium). J Neurochem. 1976;27:1197–1203
  30. Shaw S, Lieber CS. Plasma amino acid abnormalities in the alcoholic (respective role of alcohol, nutrition, and liver injury). Gastroenterology. 1978;74:677–682
  31. Speisky H, MacDonald A, Giles G, Orrego H, Israel Y. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Turnover studies. Biochem J. 1985;225:565–572
  32. Stramentinoli G, Gualano M, Galli-Kienle M. Intestinal absorption of S-adenosyl-l-methionine. J Pharmacol Exp Ther. 1979;209:323–326
  33. Traver J, Varela I, Mato JM. Effect of exogenous S-adenosyl-l-methionine on phosphatidylcholine synthesis by isolated rat hepatocytes. Biochem Pharmacol. 1984;33:1562–1564
  34. Yamada S, Mak KM, Lieber CS. Chronic ethanol consumption alters rat liver plasma membranes and potentates release of alkaline phosphatase. Gastroenterology. 1985;88:1799–1806
  35. Zappia V, Galletti P, Porcelli M, Ruggiero G, Andreana A. Uptake of adenosylmethionine and related sulfur compounds by isolated rat liver. FEBS Lett. 1978;90:331–335

 Editor: T.R. Jerrells

PII: S0741-8329(02)00230-6

Alcohol
Volume 27, Issue 3 , Pages 173-177 , July 2002