Alcohol
Volume 28, Issue 3 , Pages 181-187 , November 2002

Extremely long recovery time for the sedative effect of clonidine in male type 1 alcohol-dependent subjects in full sustained remission

  • Ulf Berggren

      Affiliations

    • The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, MÖLNDAL, SE-431 80 Mölndal, Sweden
    • ,
  • Matts Eriksson

      Affiliations

    • The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, MÖLNDAL, SE-431 80 Mölndal, Sweden
    • ,
  • Claudia Fahlke

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +46-31-7734289; fax: +46-31-7734628.
    • Department of Psychology, P.O. Box 500, Göteborg University, SE-405 30 Göteborg, Sweden
    • ,
  • Anders Sundkler

      Affiliations

    • The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, MÖLNDAL, SE-431 80 Mölndal, Sweden
    • ,
  • Jan Balldin

      Affiliations

    • The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, MÖLNDAL, SE-431 80 Mölndal, Sweden

Received 1 March 2002 ,Revised 2 August 2002 ,Accepted 20 August 2002.

References 

  1. Alling C, Balldin J, Bokström K, Gottfries CG, Karlsson I, Långström G. Studies on duration of a late recovery period after chronic abuse of ethanol. A cross-sectional study of biochemical and psychiatric indicators. Acta Psychiatr Scand. 1982;66:384–397
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: Author; 1994;
  3. Balldin J, Berggren U, Engel J, Lindstedt G, Sundkler A, Wålinder J. Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal. Biol Psychiatr. 1992;31:712–719
  4. Berggren U, Fahlke C, Norrby A, Zachrisson O, Balldin J. Subsensitive alpha-2-adrenoceptor function in male alcohol-dependent individuals during 6 months of abstinence. Drug Alcohol Depend. 2000;57:255–260
  5. Fahlke C, Berggren U, Balldin J. Mental well-being in alcohol withdrawal (relationship to alpha2-adrenoreceptor function). Alcohol Alcohol. 1999;34:718–725 a
  6. Fahlke C, Berggren U, Balldin J. Cardiovascular responses to clonidine in alcohol withdrawal (are they related to psychopathology and mental well-being?). Alcohol. 2000;21:231–237
  7. Fahlke C, Berggren U, Lundborg C, Balldin J. Psychopathology in alcohol withdrawal (relationship to alpha2-adrenoreceptor function). Alcohol Alcohol. 1999;34:750–759 b
  8. Glue P, Sellman JD, Nicholls MG, Abbott R, Joyce PR, Nutt DJ. Studies of alpha-2-adrenoceptor function in abstinent alcoholics. Br J Addict. 1989;84:97–102
  9. Klimek V, Zhu MY, Dilley G, Konick L, Overholser JC, Meltzer HY, et al. Effects of long-term cigarette smoking on the human locus coeruleus. Arch Gen Psychiatry. 2001;58:821–827
  10. Linnoila M, Mefford I, Nutt D, Adinoff B. Alcohol withdrawal and noradrenergic function. Ann Intern Med. 1987;107:875–889
  11. Maldonado R. Participation of noradrenergic pathways in the expression of opiate withdrawal (biochemical and pharmacological evidence). Neurosci Biobehav Rev. 1997;21:91–104
  12. Matussek N, Ackenheil M, Herz M. The dependence of the clonidine growth hormone test on alcohol drinking habits and the menstrual cycle. Psychoneuroendocrinology. 1984;9:173–177
  13. Müller N, Hoehe M, Klein HE, Nieberle G, Kapfhammer HP, May F, et al. Endocrinological studies in alcoholics during withdrawal and after abstinence. Psychoneuroendocrinology. 1989;14:113–123
  14. Nutt D, Glue P, Molyneux S, Clark E. Alpha-2-adrenoceptor function in alcohol withdrawal (a pilot study of the effects of iv clonidine in alcoholics and normals). Alcohol Clin Exp Res. 1988;12:14–18
  15. Szmigielski A, Szmigielski H, Wejman I. The effect of prolonged ethanol administration on central alpha 2-adrenoceptors sensitivity. Pol J Pharmacol Pharm. 1989;41:263–272
  16. Tulen JHM, van de Wetering BJM, Kruijk MPCW, von Saher RA, Moleman P, Boomsma F, et al. Cardiovascular, neuroendocrine, and sedative responses to four graded doses of clonidine in a placebo-controlled study. Biol Psychiatry. 1992;32:485–500
  17. Vaillant GE. A long-term follow-up of male alcohol abuse. Arch Gen Psychiatry. 1996;53:243–249

☆ Editor: S. Borg

PII: S0741-8329(02)00276-8

Alcohol
Volume 28, Issue 3 , Pages 181-187 , November 2002

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