Alcohol
Volume 28, Issue 3 , Pages 137-149 , November 2002

Review article: Alcohol, injury, and cellular immunity

  • Kelly A.Nordyke Messingham

      Affiliations

    • Present address: Department of Microbiology, 3-502 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA.
  • ,
  • Douglas E. Faunce
  • ,
  • Elizabeth J. Kovacs

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Stritch School of Medicine, Building 110, Room 4221, 2160 South First Avenue, Maywood, IL 60153, USA. Tel.: +1-708-327-2477; fax: +1-708-327-2813.

Received 10 June 2002 ,Accepted 19 July 2002.

References 

  1. Alexander JW. Mechanism of immunologic suppression in burn injury. J Trauma. 1990;30:S70–S75
  2. Annoni G, Weiner FR, Zern MA. Increased transforming growth factor-β 1 gene expression in human liver disease. J Hepatol. 1992;14:259–264
  3. Ayala A, Lehman DL, Herdon CD, Chaudry IH. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release. Arch Surg. 1994;129:1172–1178
  4. Baker CC, Oppenheimer L, Stephens B, Lewis FR, Trunkey DD. Epidemiology of trauma deaths. Am J Surg. 1980;140:144–150
  5. Bankey PE, Williams JG, Guice KS, Taylor SN. Interleukin-6 production after thermal injury (evidence for nonmacrophage sources in the lung and liver). Surgery. 1995;118:431–438
  6. Bautista AP. The role of Kupffer cells and reactive oxygen species in hepatic injury during acute and chronic alcohol intoxication. Alcohol Clin Exp Res. 1998;22:255S–259S
  7. Bautista AP, D'Souza NB, Lang CH, Bagwell J, Spitzer JJ. Alcohol-induced downregulation of superoxide anion release by hepatic phagocytes in endotoxemic rats. Am J Physiol. 1991;260:R969–R976
  8. Bautista AP, D'Souza NB, Lang CH, Spitzer JJ. Modulation of f-met-leu-phe induced chemotactic activity and superoxide production by neutrophils during chronic ethanol intoxication. Alcohol Clin Exp Res. 1992;16:788–794
  9. Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?. Ann Surg. 1996;224:647–664
  10. Blomquist S, Elmer O, Thorne J. Central hemodynamics and pulmonary ventilation after trauma (effect of portacaval transposition). Circ Shock. 1987;23:151–156
  11. Bode C, Ito T, Rollenhagen A, Bode JC. Effect of acute and chronic alcohol feeding on prostaglandin E2 biosynthesis in rat stomach. Dig Dis Sci. 1988;33:814–818
  12. Bone RC. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA. 1992;268:3452–3455
  13. Bone RC. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome (what we do and do not know about cytokine regulation). Crit Care Med. 1996;24:163–172
  14. Branch CD, Wilkins CF, Ross FP. The coagulum contact method of skin grafting in the treatment of burns and wounds. Surgery. 1945;19:460–467
  15. Brezel BS, Kassenbrock JM, Stein JM. Burns in substance abusers and in neurologically and mentally impaired patients. J Burn Care Rehabil. 1988;9:169–171
  16. Brodner RA, Van Gilder JC, Collins WF. Experimental spinal cord trauma (potentiation by alcohol). J Trauma. 1981;21:124–129
  17. Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA. Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans. Crit Care Med. 1992;20:1414–1419
  18. Carrigan TD, Field H, Illingworth RN, Gaffney P, Hamer DW. Toxicological screening in trauma. J Accid Emerg Med. 2000;17:33–37
  19. Choudhry MA, Messingham KAN, Namak S, Colantoni A, Fontanilla CV, Duffner LA, et al. Ethanol exacerbates T cell dysfunction after thermal injury. Alcohol. 2000;21:239–243
  20. Christou NV. The delayed hypersensitivity skin test response, granulocyte function and sepsis in surgical patients. J Burn Care Rehabil. 1985;6:157–166
  21. Colantoni A, Duffner LA, De Maria N, Fontanilla CV, Messingham KAN, Van Thiel DH, et al. Dose-dependent effect of ethanol on hepatic oxidative stress and interleukin-6 production after burn injury in the mouse. Alcohol Clin Exp Res. 2000;24:1443–1448
  22. Conboy K, Welage LS, Walawander CA, Duffy LC, Welliver RC, Zielezny MA, et al. Sepsis syndrome and associated sequelae in patients at high risk for gram-negative sepsis. Pharmacotherapy. 1995;15:66–77
  23. Cook RT. Alcohol abuse, alcoholism, and damage to the immune system—a review. Alcohol Clin Exp Res. 1998;22:1927–1942
  24. Cortese MM, Wolff M, Almeido-Hill J, Reid R, Ketcham J, Santosham M. High incidence rates of invasive pneumococcal disease in the White Mountain Apache population. Arch Intern Med. 1992;152:2277–2282
  25. Davis JM, Dineen P, Gallin JI. Neutrophil degranulation and abnormal chemotaxis after thermal injury. J Immunol. 1980;124:1467–1471
  26. Dawson DA. Heavy drinking and the risk of occupational injury. Accid Anal Prev. 1994;26:655–665
  27. Deaciuc IV, Alappat JM, McDonough KH, D'Souza NB. Effect of chronic alcohol consumption by rats on tumor necrosis factor-alpha and interleukin-6 clearance in vivo and by the isolated, perfused liver. Biochem Pharmacol. 1996;52:891–899
  28. Decker D, Schondorf M, Bidlingmaier F, Hirner A, von Ruecker AA. Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery. 1996;119:316–325
  29. Dehne NE, Mendenhall CL, Roselle GA, Grossman CJ. Cell-mediated immune responses associated with short term alcohol intake (time course and dose dependency). Alcohol Clin Exp Res. 1989;13:201–205
  30. Deitch EA. Bacterial translocation (is it of clinical significance?). Gastroenterology. 1990;98:243–244
  31. Demling RH. Burns. N Engl J Med. 1985;313:1389–1398
  32. Demling RH, LaLonde C, Ikegami K. Pulmonary edema (pathophysiology, methods of measurement, and clinical importance in acute respiratory failure). New Horiz. 1993;1:371–380
  33. Dinkel RH, Lebok U. A survey of nosocomial infections and their influence on hospital mortality rates. J Hosp Infect. 1994;28:297–304
  34. Donnelly RP, Crofford LJ, Freeman SL, Buras J, Remmers E, Wilder RL, et al. Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-κB activity in monocytes and fibroblasts. J Immunol. 1993;151:5603–5612
  35. Drost AC, Burleson DG, Cioffi WG, Jordan BS, Mason AD, Pruitt BA. Plasma cytokines following thermal injury and their relationship with patient mortality, burn size, and time postburn. J Trauma. 1993;35:335–339 a
  36. Drost AC, Burleson DG, Cioffi WG, Mason AD, Pruitt BA. Plasma cytokines after thermal injury and their relationship to infection. Ann Surg. 1993;218:74–78 b
  37. Durbin EA, Gregory MS, Messingham KAN, Fontanilla CV, Duffner LA, Kovacs EJ. The role of interleukin 6 in interferon-gamma production in thermally injured mice. Cytokine. 2000;12:1669–1675
  38. Earnest DL, Abril ER, Jolley CS, Martinez F. Ethanol and diet-induced alterations in Kupffer cell function. Alcohol Alcohol. 1993;28:73–83
  39. Espevik T, Figari IS, Shalaby MR, Lackides GA, Lewis GD, Shepard HM, et al. Inhibition of cytokine production by cyclosporin A and transforming growth factor β. J Exp Med. 1987;166:571–576
  40. Esposito AL. Community-acquired bacteremic pneumococcal pneumonia. Effect of age on manifestations and outcome. Arch Intern Med. 1984;144:945–948
  41. Faist E. The mechanisms of host defense dysfunction following shock and trauma. Curr Top Microbiol Immunol. 1996;216:259–274
  42. Faist E, Mewes A, Strasser T, Walz A, Alkan S, Baker C, et al. Alteration of monocyte function following major injury. Arch Surg. 1988;123:287–292
  43. Faist E, Schinkel C, Zimmer S. Update on the mechanisms of immune suppression of injury and immune modulation. World J Surg. 1996;20:454–459
  44. Faunce DE, Gregory MS, Kovacs EJ. Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury. J Leukoc Biol. 1997;62:733–740
  45. Faunce DE, Gregory MS, Kovacs EJ. Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6. Shock. 1998;10:135–140 a
  46. Faunce DE, Gregory MS, Kovacs EJ. Glucocorticoids protect against suppression of T cell responses in a murine model of acute ethanol exposure and thermal injury by regulating IL-6. J Leukoc Biol. 1998;64:724–732 b
  47. Flamm ES, Demopoulos HB, Seligman ML, Tomasula JJ, De Crescito V, Ransohoff J. Ethanol potentiation of central nervous system trauma. J Neurosurg. 1977;46:328–335
  48. Fontanilla CV, Faunce DE, Gregory MS, Messingham KAN, Durbin EA, Duffner LA, et al. Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma. Alcohol Clin Exp Res. 2000;24:1392–1399
  49. Friedman H. Alcohol effects on cytokine responses by immunocytes. Alcohol Clin Exp Res. 1998;22:184S–187S
  50. Friedman LN, Sullivan GM, Bevilaqua RP, Loscos R. Tuberculosis screening in alcoholics and drug addicts. Am Rev Respir Dis. 1987;136:1188–1192
  51. Fukushima R, Alexander JW, Wu JZ, Mao JX, Szczur K, Stephens AM, et al. Time course of production of cytokines and prostaglandin E2 by macrophages isolated after thermal injury and bacterial translocation. Circ Shock. 1994;42:154–162
  52. Gennari R, Alexander JW, Pyles T, Hartmann S, Ogle CK. Effects of anti-murine interleukin-. 1994;6(on bacterial translocation during gut-derived sepsis. Arch Surg 129):1191–1197
  53. Gentilello LM, Cobean RA, Walker AP, Moore EE, Wertz MJ, Dellinger EP. Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. J Trauma. 1993;34:669–674
  54. Germann G, Barthold U, Lefering R, Raff T, Hartmann B. The impact of risk factors and pre-existing conditions on the mortality of burn patients and the precision of predictive admission scoring systems. Burns. 1997;23:195–203
  55. Girouard L, Mandrekar P, Catalano D, Szabo G. Regulation of monocyte interleukin-12 production by acute alcohol (a role for inhibition by interleukin-10). Alcohol Clin Exp Res. 1998;22:211–216
  56. Goldstein DB. Ethanol-induced adaptation in biological membranes. Ann N Y Acad Sci. 1987;492:103–111
  57. Grbic JT, Mannick JA, Gough DB, Rodrick ML. The role of prostaglandin E2 in immune suppression following injury. Ann Surg. 1991;214:253–263
  58. Gregory MS, Duffner LA, Faunce DE, Kovacs EJ. Estrogen mediates the sex difference in post-burn immunosuppression. J Endocrinol. 2000;164:129–138 a
  59. Gregory MS, Duffner LA, Hahn EL, Tai HH, Faunce DE, Kovacs EJ. Differential production of prostaglandin E2 in male and female mice subjected to thermal injury contributes to the gender difference in immune function (possible role for 15-hydroxyprostaglandin dehydrogenase). Cell Immunol. 2000;205:94–102 b
  60. Gregory MS, Faunce DE, Duffner LA, Kovacs EJ. Gender difference in cell-mediated immunity after thermal injury is mediated, in part, by elevated levels of interleukin-6. J Leukoc Biol. 2000;67:319–326 c
  61. Grobmyer SR, Maniscalco SP, Purdue GF, Hunt JL. Alcohol, drug intoxication, or both at the time of burn injury as a predictor of complications and mortality in hospitalized patients with burns. J Burn Care Rehabil. 1996;17:532–539
  62. Grossman CJ, Mendenhall CL, Roselle GA. Alcohol and immune regulation. I. In vivo effects of ethanol on concanavalin A sensitive thymic lymphocyte function. Int J Immunopharmacol. 1988;10:187–195
  63. Guo Y, Dickerson C, Chrest FJ, Adler WH, Munster AM, Winchurch RA. Increased levels of circulating interleukin 6 in burn patients. Clin Immunol Immunopathol. 1990;54:361–371
  64. Gurney JG, Rivara FP, Mueller BA, Newell DW, Copass MK, Jurkovich GJ. The effects of alcohol intoxication on the initial treatment and hospital course of patients with acute brain injury. J Trauma. 1992;33:709–713
  65. Hansbrough J, Peterson V, Zapata-Sirvent R, Claman HN. Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs. Surgery. 1984;95:290–296
  66. Haum A, Perbix W, Hack HJ, Stark GB, Spilker G, Doehn M. Alcohol and drug abuse in burn injuries. Burns. 1995;21:194–199
  67. Hensler T, Hecker H, Heeg K, Heidecke CD, Bartels H, Barthlen W, et al. Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect Immun. 1997;65:2283–2291
  68. Hoek JB, Rubin E. Alcohol and membrane-associated signal transduction. Alcohol Alcohol. 1990;25:143–156
  69. Honkanen R, Ertama L, Kuosmanen P, Linnoila M, Alha A, Visuri T. The role of alcohol in accidental falls. J Stud Alcohol. 1983;44:231–245
  70. Honkanen R, Visuri T, Kilpio J. Blood alcohol levels in accident victims. Ann Chir Gynaecol Fenn. 1975;64:365–368
  71. Horgan AF, Mendez MV, O'Riordain DS, Holzheimer RG, Mannick JA, Rodrick ML. Altered gene transcription after burn injury results in depressed T-lymphocyte activation. Ann Surg. 1994;220:342–352 a
  72. Horgan AF, O'Riordain DS, Chin DH, Mannick JA, Rodrick ML. The role of cyclic adenosine monophosphate in the suppression of cellular immunity after thermal injury. Arch Surg. 1994;129:1284–1289 b
  73. Howland J, Hingson R. Alcohol as a risk factor for injuries or death due to fires and burns (review of the literature). Public Health Rep. 1987;102:475–483
  74. Hsiung L, Wang J, Waltenbaugh C. Flow cytometric analysis of lymphocyte subsets of mice maintained on an ethanol-containing liquid diet. Alcohol Clin Exp Res. 1994;18:12–20
  75. Huth JF, Maier RV, Simonowitz DA, Herman CM. Effect of acute ethanolism on the hospital course and outcome of injured automobile drivers. J Trauma. 1983;23:494–498
  76. Imhoff M, Gahr RH, Hoffmann P. Delayed cutaneous hypersensitivity after multiple injury and severe burn. Ann Ital Chir. 1990;61:525–528
  77. Jagger J, Fife D, Vernberg K, Jane JA. Effect of alcohol intoxication on the diagnosis and apparent severity of brain injury. Neurosurgery. 1984;15:303–306
  78. Jareo PW, Preheim LC, Gentry MJ. Ethanol ingestion impairs neutrophil bactericidal mechanisms against Streptococcus pneumoniae. Alcohol Clin Exp Res. 1996;20:1646–1652
  79. Jareo PW, Preheim LC, Lister PD, Gentry MJ. The effect of ethanol ingestion on killing of Streptococcus pneumoniae, Staphylococcus aureus and Staphylococcus epidermidis by rat neutrophils. Alcohol Alcohol. 1995;30:311–318
  80. Jayasinghe R, Gianutsos G, Hubbard AK. Ethanol-induced suppression of cell-mediated immunity in the mouse. Alcohol Clin Exp Res. 1992;16:331–335
  81. Jerrells TR, Marietta CA, Eckardt MJ, Majchrowicz E, Weight FF. Effects of ethanol administration on parameters of immunocompetency in rats. J Leukoc Biol. 1986;39:499–510
  82. Jerrells TR, Saad AJ, Domiati-Saad R. Effects of ethanol on parameters of cellular immunity and host defense mechanisms to infectious agents. Alcohol. 1992;9:459–463
  83. Jerrells TR, Saad AJ, Kruger TE. Ethanol-induced suppression of in vivo host defense mechanisms to bacterial infection. Adv Exp Med Biol. 1993;335:153–157
  84. Jones JD, Barber B, Engrav L, Heimbach D. Alcohol use and burn injury. J Burn Care Rehabil. 1991;12:148–152
  85. Jurkovich GJ, Rivara FP, Gurney JG, Flinger C, Ries R, Mueller BA, et al. The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma. JAMA. 1993;270:51–56
  86. Jurkovich GJ, Rivara FP, Gurney JG, Seguin D, Fligner CL, Copass M. Effects of alcohol intoxication on the initial assessment of trauma patients. Ann Emerg Med. 1992;21:704–708
  87. Kahlke V, Dohm C, Brotzmann K, Schreiber S, Schroder J. Gender-related therapy (early IL-10 administration after hemorrhage restores immune function in males but not in females). Shock. 2000;14:354–359
  88. Kawakami M, Meyer AA, Johnson MC, deSerres S, Peterson HD. Chronic ethanol exposure before injury produces greater immune dysfunction after thermal injury in rats. J Trauma. 1990;30:27–31
  89. Kawakami M, Switzer BR, Herzog SR, Meyer AA. Immune suppression after acute ethanol ingestion and thermal injury. J Surg Res. 1991;51:210–215
  90. Kelley D, Lynch JB. Burns in alcohol and drug users result in longer treatment times with more complications. J Burn Care Rehabil. 1992;13:218–220
  91. Kelly JL, Lyons A, Soberg CC, Mannick JA, Lederer JA. Anti-interleukin-10 antibody restores burn-induced defects in T-cell dysfunction. Surgery. 1997;122:146–152
  92. Kimchi A. Cytokine triggered molecular pathways that control cell cycle arrest. J Cell Biochem. 1992;50:1–9
  93. Knott DH, Beard JD. The effect of chronic ethanol administration on the response of the dog to repeated acute hemorrhages. Am J Med Sci. 1967;254:178–188
  94. Koelega HS. Alcohol and vigilance performance (a review). Psychopharmacology. 1995;118:233–249
  95. Kowal-Vern A, Walenga JM, Hoppensteadt D, Sharp-Pucci M, Gamelli RL. Interleukin-2 and interleukin-6 in relation to burn wound size in the acute phase of thermal injury. J Am Coll Surg. 1994;178:357–362
  96. Laskin CA, Vidins E, Blendis LM, Soloninka CA. Autoantibodies in alcoholic liver disease. Am J Med. 1990;89:129–133
  97. Lazaron V, Barke RA. Gram-negative bacterial sepsis and the sepsis syndrome. Urol Clin North Am. 1999;26:687–699
  98. Li G, Keyl PM, Smith GS, Baker SP. Alcohol and injury severity (reappraisal of the continuing controversy). J Trauma. 1997;42:562–569
  99. Loose LD, Megirian R, Turinsky J. Biochemical and functional alterations in macrophages after thermal injury. Infect Immun. 1984;44:554–558
  100. MacGregor RR. Alcohol and immune defense. JAMA. 1986;256:1474–1479
  101. Mandrekar P, Catalano D, Girouard L, Szabo G. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine. 1996;8:567–577
  102. Maull KI, Clapp AR, Ellis LM. Driver behaviour of ethanol-impaired non-vehicular trauma victims. Arch Emerg Med. 1986;3:16–19
  103. McCarter MD, Mack VE, Daly JM, Naama HA, Calvano SE. Trauma-induced alterations in macrophage function. Surgery. 1998;123:96–101
  104. McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis. 1993;13:170–182
  105. McGill V, Kowal-Vern A, Fisher SG, Kahn S, Gamelli RL. The impact of substance use on mortality and morbidity from thermal injury. J Trauma. 1995;38:931–934
  106. Mendenhall CL, Theus SA, Roselle GA, Grossman CJ, Rouster SD. Biphasic in vivo immune function after low-versus high-dose alcohol consumption. Alcohol. 1997;14:255–260
  107. Messingham KAN, Fontanilla CV, Colantoni A, Duffner LA, Kovacs EJ. Cellular immunity after ethanol exposure and burn injury (dose and time dependence). Alcohol. 2000;22:35–44
  108. Messingham KAN, Heinrich SA, Kovacs EJ. Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production. J Leukoc Biol. 2001;70:887–895
  109. Messingham KAN, Heinrich SA, Schilling EM, Kovacs EJ. Interleukin-4 treatment restores cellular immunity after ethanol exposure and burn injury. Alcohol Clin Exp Res. 2002;26:519–526
  110. Mikszta JA, Waltenbaugh C, Kim BS. Impaired antigen presentation by splenocytes of ethanol-consuming C57BL/6 mice. Alcohol. 1995;12:265–271
  111. Miller CL, Baker CC. Changes in lymphocyte activity after thermal injury. The role of suppressor cells. J Clin Invest. 1979;63:202–210
  112. Miller-Graziano CL, Fink M, Wu J-Y, Szabo G, Kodys K. Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch Surg. 1988;123:293–299
  113. Miller-Graziano CL, Szabo G, Griffey K, Mehta B, Kodys K, Catalano D. Role of elevated monocyte transforming growth factor beta (TGF β) production in posttrauma immunosuppression. J Clin Immunol. 1991;11:95–102
  114. Mills CD, Caldwell MD, Gann DS. Evidence of a plasma-mediated “window” of immunodeficiency in rats following trauma. J Clin Immunol. 1989;9:139–150
  115. Moss NM, Gough DB, Jordan AL, Grbic JT, Wood JJ, Rodrick ML, et al. Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery. 1988;104:882–887
  116. Munster AM. Alterations of the host defense mechanism in burns. Surg Clin North Am. 1970;50:1217–1225
  117. Munster AM. Burns of the world. J Burn Care Rehabil. 1996;17:477–484
  118. Munster AM, Eurenius K, Katz RM, Canales L, Foley FD, Mortensen RF. Cell-mediated immunity after thermal injury. Ann Surg. 1973;177:139–143
  119. Nakanishi T, Nishi Y, Sato EF, Ishii M, Hamada T, Inoue M. Thermal injury induces thymocyte apoptosis in the rat. J Trauma. 1998;44:143–148
  120. Napolitano LM, Koruda MJ, Zimmerman K, McCowan K, Chang J, Meyer AA. Chronic ethanol intake and burn injury (evidence for synergistic alteration in gut and immune integrity). J Trauma. 1995;38:198–207
  121. Ninnemann JL, Fisher JC, Frank HA. Prolonged survival of human skin allografts following thermal injury. Transplantation. 1978;25:69–72
  122. Nishimura T, Nishiura T, deSerres S, Nakagawa T, Meyer AA. Transforming growth factor-beta1 and splenocyte apoptotic cell death after burn injuries. J Burn Care Rehabil. 2000;21:128–134
  123. Oberholzer A, Keel M, Zellweger R, Steckholzer U, Trentz O, Ertel W. Incidence of septic complications and multiple organ failure in severely injured patients is sex specific. J Trauma. 2000;48:932–937
  124. Ogle CK, Guo X, Szczur K, Hartmann S, Ogle JD. Production of tumor necrosis factor, interleukin-6 and prostaglandin E2 by LPS-stimulated rat bone marrow macrophages after thermal injury (effect of indomethacin). Inflammation. 1994;18:175–185 a
  125. Ogle CK, Mao JX, Wu JZ, Ogle JD, Alexander JA. The 1994 Lindberg Award. The production of tumor necrosis factor, interleukin-1, interleukin-6, and prostaglandin E2 by isolated enterocytes and gut macrophages (effect of lipopolysaccharide and thermal injury). J Burn Care Rehabil. 1994;15:470–477 b
  126. O'Riordain DS, Mendez MV, Holzheimer RG, Collins K, Mannick JA, Rodrick ML. Interleukin-2 receptor expression and function following thermal injury. Arch Surg. 1995;130:165–170
  127. O'Riordain MG, Collins KH, Pilz M, Saporoschetz IB, Mannick JA, Rodrick ML. Modulation of macrophage hyperactivity improves survival in a burn-sepsis model. Arch Surg. 1992;127:152–157
  128. O'Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, Rodrick ML. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg. 1995;222:482–490
  129. O'Sullivan ST, O'Connor TP. Immunosuppression following thermal injury (the pathogenesis of immunodysfunction). Br J Plast Surg. 1997;50:615–623
  130. Paronetto F. Immunologic reactions in alcoholic liver disease. Semin Liver Dis. 1993;13:183–195
  131. Patel M, Keshavarzian A, Kottapalli V, Badie B, Winship D, Fields JZ. Human neutrophil functions are inhibited in vitro by clinically relevant ethanol concentrations. Alcohol Clin Exp Res. 1996;20:275–283
  132. Patel PJ, Faunce DE, Gregory MS, Duffner LA, Kovacs EJ. Elevation in pulmonary neutrophils and prolonged production of pulmonary macrophage inflammatory protein-2 after burn injury with prior alcohol exposure. Am J Respir Cell Mol Biol. 1999;20:1229–1237
  133. Pennington HL, Hall PM, Wilce PA, Worrall S. Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. J Gastroenterol Hepatol. 1997;12:305–313
  134. Peterson JD, Vasquez K, Waltenbaugh C. Interleukin-12 therapy restores cell-mediated immunity in ethanol-consuming mice. Alcohol Clin Exp Res. 1998;22:245–251
  135. Peterson V, Hansbrough J, Buerk C, Rundus C, Wallner S, Smith H, et al. Regulation of granulopoiesis following severe thermal injury. J Trauma. 1983;23:19–24
  136. Polk HC. Prolongation of xenograft survival in patients with pseudomonas sepsis (a clarification). Surg Forum. 1968;19:514–515
  137. Pories SE, Gamelli RL, Vacek P, Goodwin G, Shinozaki T, Harris F. Intoxication and injury. J Trauma. 1992;32:60–64
  138. Pruitt BA. Infection and the burn patient. Br J Surg. 1990;77:1081–1082
  139. Puyana JC, Pellegrini JD, De AK, Kodys K, Silva WE, Miller CL. Both T-helper-1- and T-helper-2-type lymphokines are depressed in posttrauma anergy. J Trauma. 1998;44:1037–1046
  140. Raff T, Germann G, Barthold U. Factors influencing the early prediction of outcome from burns. Acta Chir Plast. 1996;38:122–127
  141. Ramzy PI, Barret JP, Herndon DN. Thermal injury. Crit Care Clin. 1999;15:333–352
  142. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA. 1995;273:117–123
  143. Rivara FP, Gurney JG, Ries RK, Seguin DA, Copass MK, Jurkovich GJ. A descriptive study of trauma, alcohol, and alcoholism in young adults. J Adolesc Health. 1992;13:663–667
  144. Rivier C. Effect of pretreatment with alcohol on subsequent endocrine and immune responses in the adult male rat. Alcohol Clin Exp Res. 1997;21:1690–1694
  145. Runyan CW, Bangdiwala SI, Linzer MA, Sacks JJ, Butts J. Risk factors for fatal residential fires. N Engl J Med. 1992;327:859–863
  146. Saad AJ, Jerrells TR. Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcohol Clin Exp Res. 1991;15:796–803
  147. Sakai H, Daniels JC, Beathard GA, Lewis SR, Lynch JB, Ritzmann SE. Mixed lymphocyte culture reaction in patients with acute thermal burns. J Trauma. 1974;14:53–57
  148. Sartorelli KH, Silver GM, Gamelli RL. The effect of granulocyte colony-stimulating factor (G-CSF) upon burn-induced defective neutrophil chemotaxis. J Trauma. 1991;31:523–530
  149. Schafer C, Schips I, Landig J, Bode JC, Bode C. Tumor-necrosis-factor and interleukin-6 response of peripheral blood monocytes to low concentrations of lipopolysaccharide in patients with alcoholic liver disease. Z Gastroenterol. 1995;33:503–508
  150. Schluter B, Konig B, Bergmann U, Muller FE, Konig W. Interleukin 6—a potential mediator of lethal sepsis after major thermal trauma (evidence for increased IL-6 production by peripheral blood mononuclear cells). J Trauma. 1991;31:1663–1670
  151. Schodde H, Hurst S, Munroe M, Barrett T, Waltenbaugh C. Ethanol ingestion inhibits cell-mediated immune responses of unprimed T-cell receptor transgenic mice. Alcohol Clin Exp Res. 1996;20:890–899
  152. Schroder J, Kahlke V, Staubach K-H, Zabel P, Stuber F. Gender differences in human sepsis. Arch Surg. 1998;133:1200–1205
  153. Schwacha MG, Somers SD. Thermal injury–induced immunosuppression in mice (the role of macrophage-derived reactive nitrogen intermediates). J Leukoc Biol. 1998;63:51–58
  154. Shirani KZ, Vaughan GM, Mason AD, Pruitt BA. Update on current therapeutic approaches in burns. Shock. 1996;5:4–16
  155. Shoup M, Weisenberger JM, Wang JL, Pyle JM, Gamelli RL, Shankar R. Mechanisms of neutropenia involving myeloid maturation arrest in burn sepsis. Ann Surg. 1998;228:112–122
  156. Slukvin II, Jerrells TR. Different pathways of in vitro ethanol-induced apoptosis in thymocytes and splenic T and B lymphocytes. Immunopharmacology. 1995;31:43–57
  157. Smith GS, Kraus JF. Alcohol and residential, recreational, and occupational injuries (a review of the epidemiologic evidence). Ann Rev Pub Health. 1988;9:99–121
  158. Soderstrom CA, Smith GS, Kufera JA, Dischinger PC, Hebel JR, McDuff DR, et al. The accuracy of the CAGE, the Brief Michigan Alcoholism Screening Test, and the Alcohol Use Disorders Identification Test in screening trauma center patients for alcoholism. J Trauma. 1997;43:962–969
  159. Solomkin JS, Nelson RD, Chenoweth DE, Solem LD, Simmons RL. Regulation of neutrophil migratory function in burn injury by complement activation products. Ann Surg. 1984;200:742–746
  160. Spaite DW, Criss EA, Weist DJ, Valenzuela TD, Judkins D, Meislin HW. A prospective investigation of the impact of alcohol consumption on helmet use, injury severity, medical resource utilization, and health care costs in bicycle-related trauma. J Trauma. 1995;38:287–290
  161. Sparkes BG. Mechanisms of immune failure in burn injury. Vaccine. 1993;11:504–510
  162. Starkenburg S, Munroe ME, Waltenbaugh C. Early alteration in leukocyte populations and Th1/Th2 function in ethanol-consuming mice. Alcohol Clin Exp Res. 2001;25:1221–1230
  163. Szabo G. Monocytes, alcohol use, and altered immunity. Alcohol Clin Exp Res. 1998;22:216S–219S
  164. Szabo G, Mandrekar P, Girouard L, Catalano D. Regulation of human monocyte functions by acute ethanol treatment (decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production). Alcohol Clin Exp Res. 1996;20:900–907
  165. Szabo G, Verma B, Catalano D. Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure (the role of impaired monocyte antigen presentation capacity and mediator production). J Leukoc Biol. 1993;54:534–544
  166. Szabo G, Verma BK, Fogarasi M, Catalano DE. Induction of transforming growth factor-β and prostaglandin E2 production by ethanol in human monocytes. J Leukoc Biol. 1992;52:602–610
  167. Tamura DY, Moore EE, Partrick DA, Johnson JL, Offner PJ, Harbeck RJ, et al. Clinically relevant concentrations of ethanol attenuate primed neutrophil bactericidal activity. J Trauma. 1998;44:320–324
  168. Teodorczyk-Injeyan JA, Sparkes BG, Mills GB, Peters WJ, Falk RE. Impairment of T cell activation in burn patients (a possible mechanism of thermal injury–induced immunosuppression). Clin Exp Immunol. 1986;65:570–581
  169. Thal ER, Bost RO, Anderson RJ. Effects of alcohol and other drugs on traumatized patients. Arch Surg. 1985;120:708–712
  170. Tilg H, Wilmer A, Vogel W, Herold M, Nolchen B, Judmaier G, et al. Serum levels of cytokines in chronic liver diseases. Gastroenterology. 1992;103:264–274
  171. Tonnesen H, Kehlet H. Preoperative alcoholism and postoperative morbidity. Br J Surg. 1999;86:869–874
  172. Tonnesen H, Petersen KR, Hojgaard L, Stokholm KH, Nielsen HJ, Knigge U, et al. Postoperative morbidity among symptom-free alcohol misusers. Lancet. 1992;340:334–337
  173. Tulloh BR, Collopy BT. Positive correlation between blood alcohol level and ISS in road trauma. Injury. 1994;25:539–543
  174. Ueyama M, Maruyama I, Osame M, Sawada Y. Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med. 1992;120:693–698
  175. Vinson DC, Mabe N, Leonard LL, Alexander J, Becker J, Boyer J, et al. Alcohol and injury. A case-crossover study. Arch Fam Med. 1995;4:505–511
  176. Wahl SM. Transforming growth factor beta (TGF-beta) in inflammation (a cause and a cure). J Clin Immunol. 1992;12:61–74
  177. Waller PF, Stewart JR, Hansen AR, Stutts JC, Popkin CL, Rodgman EA. The potentiating effects of alcohol on driver injury. JAMA. 1986;256:1461–1466
  178. Waltenbaugh C, Peterson JD. Ethanol impairs the induction of delayed hypersensitivity in C57BL/6 mice. Alcohol. 1997;14:149–153
  179. Waltenbaugh C, Vasquez K, Peterson JD. Alcohol consumption alters antigen-specific Th1 responses (mechanisms of deficit and repair). Alcohol Clin Exp Res. 1998;22:220S–223S
  180. Ward RE, Flynn TC, Miller PW, Blaisdell WF. Effects of ethanol ingestion on the severity and outcome of trauma. Am J Surg. 1982;144:153–157
  181. Warda L, Tenenbein M, Moffatt ME. House fire injury prevention update. Part I. A review of risk factors for fatal and non-fatal house fire injury. Inj Prev. 1999;5:145–150
  182. Watson JS. Illegal blood alcohol levels and traffic death rates. Percept Mot Skills. 1994;79:82
  183. Winkelstein A. What are the immunological alterations induced by burn injury?. J Trauma. 1984;24:S72–S83
  184. Wolfe JH, Wu AV, O'Connor NE, Saporoschetz I, Mannick JA. Anergy, immunosuppressive serum, and impaired lymphocyte blastogenesis in burn patients. Arch Surg. 1982;117:1266–1271
  185. Wu JZ, Ogle CK, Mao JX, Szczur K, Fischer JE, Ogle JD. The increased potential for the production of inflammatory cytokines by Kupffer cells and splenic macrophages eight days after thermal injury. Inflammation. 1995;19:529–541
  186. Yamagishi Y, Horie Y, Kato S, Kajihara M, Tamai H, Granger DN, et al. Ethanol modulates gut ischemia/reperfusion-induced liver injury in rats. Am J Physiol Gastrointest Liver Physiol. 2002;282:G640–G646
  187. Yang L, Hsu B. The roles of macrophage (M phi) and PGE-2 in postburn immunosuppression. Burns. 1992;18:132–136
  188. Zedler S, Bone RC, Baue AE, von Donnersmarck GH, Faist E. T-cell reactivity and its predictive role in immunosuppression after burns. Crit Care Med. 1999;27:66–72
  189. Zeldin G, Yang SQ, Yin M, Lin HZ, Rai R, Diehl AM. Alcohol and cytokine-inducible transcription factors. Alcohol Clin Exp Res. 1996;20:1639–1645
  190. Zhou D, Munster A, Winchurch RA. Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-β. FASEB J. 1991;5:2582–2585
  191. Zhou DH, Munster AM, Winchurch RA. Inhibitory effects of interleukin 6 on immunity. Possible implications in burn patients. Arch Surg. 1992;127:65–68
  192. Zink BJ, Feustel PJ. Effects of ethanol on respiratory function in traumatic brain injury. J Neurosurg. 1995;82:822–828

 Editor: T.R. Jerrells

☆☆ Editor's Note: This Review Article, as with all submissions to Alcohol, was subjected to peer-review. As with all other published material in Alcohol, the authors of this Review Article satisfactorily addressed the concerns of the reviewers. Therefore, this Review Article should be considered as a peer-reviewed publication.

PII: S0741-8329(02)00278-1

Alcohol
Volume 28, Issue 3 , Pages 137-149 , November 2002