Alcohol
Volume 28, Issue 3 , Pages 169-179 , November 2002

Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat

  • Michael F. Stromberg

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-215-823-4325; fax: +1-215-823-5171.
    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
    • ,
  • Till Sengpiel

      Affiliations

    • Philipps-University of Marberg, Marberg 35043, Germany
    • ,
  • Scott A. Mackler

      Affiliations

    • Department of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
    • ,
  • Joseph R. Volpicelli

      Affiliations

    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
    • ,
  • Charles P. O'Brien

      Affiliations

    • Center For Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    • Philadelphia VAMC, Philadelphia, PA 19104, USA
    • ,
  • Wolfgang H. Vogel

      Affiliations

    • Thomas Jefferson University, Philadelphia, PA 19104, USA

Received 11 January 2002 ,Revised 22 July 2002 ,Accepted 29 July 2002.

References 

  1. Acquas E, Meloni M, Di Chiara G. Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release. Eur J Pharmacol. 1993;230:239–241
  2. Altshuler HL, Phillips PE, Feinhandler DA. Alteration of ethanol self-administration by naltrexone. Life Sci. 1980;26:679–688
  3. Benjamin D, Grant ER, Pohorecky LA. Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. Brain Res. 1993;621:137–140
  4. Brodie MS, Shefner SA, Dunwiddie TV. Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res. 1990;508:65–69
  5. Carroll ME, Lac ST, Walker MJ, Kragh R, Newman T. Effects of naltrexone on intravenous cocaine self-administration in rats during food satiation and deprivation. J Pharmacol Exp Ther. 1986;238:1–7
  6. Corrigall WA, Coen KM. Opiate antagonists reduce cocaine but not nicotine self-administration. Psychopharmacology (Berl). 1991;104:167–170
  7. Criado JR, Lee RS, Berg GI, Henriksen SJ. Sensitivity of nucleus accumbens neurons in vivo to intoxicating doses of ethanol. Alcohol Clin Exp Res. 1995;19:164–169
  8. Critcher EC, Lin CI, Patel J, Myers RD. Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone. Pharmacol Biochem Behav. 1983;18:225–229
  9. De Vry J, Donselaar I, Van Ree JM. Food deprivation and acquisition of intravenous cocaine self-administration in rats (effect of naltrexone and haloperidol). J Pharmacol Exp Ther. 1989;251:735–740
  10. Di Chiara G, Imperato A. Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats. Eur J Pharmacol. 1985;115:131–132
  11. Ettenberg A, Pettit HO, Bloom FE, Koob GF. Heroin and cocaine intravenous self-administration in rats (mediation by separate neural systems). Psychopharmacology (Berl). 1982;78:204–209
  12. Froehlich JC, Harts J, Lumeng L, Li T-K. Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol Biochem Behav. 1990;35:385–390
  13. Glick SD, Cox RS, Crane AM. Changes in morphine self-administration and morphine dependence after lesions of the caudate nucleus in rats. Psychopharmacologia. 1975;41:219–224
  14. Gonzales RA, Weiss F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in nucleus accumbens. J Neurosci. 1998;18:10663–10671
  15. Gorelick DA. Alcohol and cocaine (clinical and pharmacological interactions). In:  Galanter M editors. Recent Developments in Alcoholism, Vol. 10 (Alcohol and Cocaine: Similarities and Differences). New York: Plenum Press; 1992;p. 37–56
  16. Hall WC, Talbert RL, Ereshefsky L. Cocaine abuse and its treatment. Pharmacotherapy. 1990;10:47–65
  17. Hemby SE, Smith JE, Dworkin SI. The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats. J Pharmacol Exp Ther. 1996;277:1247–1258
  18. Hersh D, Van Kirk JR, Kranzler HR. Naltrexone treatment of comorbid alcohol and cocaine use disorders. Psychopharmacology (Berl). 1998;139:44–52
  19. Hubbell CL, Czirr SA, Hunter GA, Beaman CM, LeCann NC, Reid LD. Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations. Alcohol. 1986;3:39–54
  20. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  21. Koob, G. F. (1992). Neural mechanisms of drug reinforcement. In P. W. Kalivas, & H. H. Samson (Eds.), The Neurobiology of Drug and Alcohol Addiction (vol. 654; p. 171). New York: New York Academy of Sciences.
  22. Ma F, Falk JL, Lau CE. Cocaine pharmacodynamics after intravenous and oral administration in rats (relation to pharmacokinetics). Psychopharmacology (Berl). 1999;144:323–332
  23. Mello NK, Lukas SE, Mendelson JH, Drieze J. Naltrexone–buprenorphine interactions (effects on cocaine self-administration). Neuropsychopharmacology. 1993;9:211–224
  24. Miller NS, Millman RB, Keskinen S. The diagnosis of alcohol, cocaine, and other drug dependence in an inpatient treatment population. J Subst Abuse Treat. 1989;6:37–40
  25. Myers RD, Critcher EC. Naloxone alters alcohol drinking induced in the rat by tetrahydropapaveroline (THP) infused ICV. Pharmacol Biochem Behav. 1982;16:827–836
  26. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatry. 1992;49:881–887
  27. Oslin DW, Pettinati HM, Volpicelli JR, Wolf AL, Kampman KM, O'Brien CP. The effects of naltrexone on alcohol and cocaine use in dually addicted patients. J Subst Abuse Treat. 1999;16:163–167
  28. Perez-Reyes M, Jeffcoat AR. Ethanol/cocaine interaction (cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects). Life Sci. 1992;51:553–563
  29. Ramsey NF, Gerrits MA, Van Ree JM. Naltrexone affects cocaine self-administration in naive rats through the ventral tegmental area rather than dopaminergic target regions. Eur Neuropsychopharmacol. 1999;9:93–99
  30. Reid LD, Delconte JD, Nichols ML, Bilsky EJ, Hubbell CL. Tests of opioid deficiency hypothesis of alcoholism. Alcohol. 1991;8:247–257
  31. Reith MEA, Meisler BE, Sershen H, Lajtha A. Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior. Biochem Pharmacol. 1986;35:1123–1129
  32. Revusky SH, Bedarf EW. Association of illness with prior ingestion of novel foods. Science. 1967;155:219–220
  33. Rounsaville BJ, Anton SF, Carroll K, Budde D, Prusoff BA, Gawin F. Psychiatric diagnoses of treatment-seeking cocaine abusers. Arch Gen Psychiatry. 1991;48:43–51
  34. Schmitz JM, Stotts AL, Rhoades HM, Grabowski J. Naltrexone and relapse prevention treatment for cocaine-dependent patients. Addict Behav. 2001;26:167–180
  35. Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP, Dewey SL. The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat. Pharmacol Biochem Behav. 2001;68:291–299
  36. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry. 1992;49:876–880
  37. Volpicelli JR, Davis MA, Olgin JE. Naltrexone blocks the post-shock increase of ethanol consumption. Life Sci. 1986;38:841–847
  38. Volpicelli JR, O'Brien CP, Alterman AI, Hayshida M. Naltrexone and the treatment of alcohol dependence (initial observations). In:  Reid LD editors. Opioids, Bulimia, and Alcohol Abuse & Alcoholism. New York: Springer-Verlag; 1990;p. 195–214
  39. Volpicelli JR, Rhines KC, Rhines JS, Volpicelli LA, Alterman AI, O'Brien CP. Naltrexone and alcohol dependence. Role of subject compliance. Arch Gen Psychiatry. 1997;54:737–742
  40. Volpicelli JR, Watson NT, King AC, Sherman CE, O'Brien CP. Effect of naltrexone on alcohol “high” in alcoholics. Am J Psychiatry. 1995;152:613–615
  41. Walsh SL, Sullivan JT, Preston KL, Garner JE, Bigelow GE. Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans. J Pharmacol Exp Ther. 1996;279:524–538
  42. Weiss F, Lorang MT, Bloom FE, Koob GF. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens; genetic and motivational determinants. J Pharmacol Exp Ther. 1993;267:250–258
  43. Williams KL, Woods JH. Conditioned effects produced by naltrexone doses that reduce ethanol-reinforced responding in rhesus monkeys. Alcohol Clin Exp Res. 1999;23:708–715
  44. Wise RA, Bozarth MA. A psychomotor stimulant theory of addiction. Psychol Rev. 1987;94:469–492
  45. Yoshimoto K, McBride WJ, Lumeng L, Li T-K. Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol. 1992;9:17–22

☆ Editor: T.R. Jerrells

PII: S0741-8329(02)00280-X

Alcohol
Volume 28, Issue 3 , Pages 169-179 , November 2002

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