Alcohol
Volume 29, Issue 2 , Pages 83-90 , February 2003

Effects of chronic ethanol treatment on the angiotensin II–mediated p42/p44 mitogen-activated protein kinase and phosphorylase a activation in rat hepatocytes

  • Yu-I Weng

      Affiliations

    • Present address: Department of Ophthalmology, University of Cincinnati, Suite 350 HPB, 3223 Eden Avenue, Cincinnati, OH 45267, USA.
  • ,
  • Shivendra D Shukla

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-573-882-2740; fax: +1-573-884-4558.

Received 12 December 2001 ,Revised 20 November 2002 ,Accepted 22 November 2002.

References 

  1. Blackmore PF, Exton JH. Assessment of effects of vasopressin, angiotensin II, and glucagon on Ca2+ fluxes and phosphorylase activity in liver. Methods Enzymol. 1985;109:550–558
  2. Chen J, Bao H, Sawyer S, Kunos G, Gao B. Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver. Biochem Biophys Res Commun. 1997;239:666–669
  3. Chen J, Clemens DL, Cederbaum AI, Gao B. Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells (evidence for a lack of involvement of ethanol metabolism). Clin Biochem. 2001;34:203–209
  4. Clauser E, Curnow KM, Davies E, Conchon S, Teutsch B, Vianello B, et al. Angiotensin II receptors (protein and gene structures, expression and potential pathological involvements). Eur J Endocrinol. 1996;134:403–411
  5. Dajani OF, Rottingen JA, Sandnes D, Horn RS, Refsnes M, Thoresen GH, et al. Growth-promoting effects of Ca2+-mobilizing agents in hepatocytes (lack of correlation between the acute activation of phosphoinositide-specific phospholipase C and the stimulation of DNA synthesis by angiotensin II, vasopressin, norepinephrine, and prostaglandin F). J Cell Physiol. 1996;168:608–617
  6. Dent P, Lavoinne A, Nakielny S, Caudwell FB, Watt P, Cohen P. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature. 1990;348:302–308
  7. Garrison JC, Borland MK, Florio VA, Twible DA. The role of calcium ion as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes. J Biol Chem. 1979;254:7147–7156
  8. González-Espinosa C, Garcı́a-Sáinz JA. Angiotensin II and active phorbol esters induce proto-oncogene expression in isolated rat hepatocytes. Biochim Biophys Acta. 1992;1136:309–314
  9. Hems DA. Short-term hormonal control of hepatic carbohydrate and lipid catabolism. FEBS Lett. 1977;80:237–245
  10. Hems DA, Rodrigues LM, Whitton PD. Rapid stimulation by vasopressin, oxytocin and angiotensin II of glycogen degradation in hepatocyte suspensions. Biochem J. 1978;172:311–317
  11. Hoek JB, Taraschi TF, Higashi K, Rubin E, Thomas AP. Phospholipase C activation by ethanol in rat hepatocytes is unaffected by chronic ethanol feeding. Biochem J. 1990;272:59–64
  12. Jamaluddin M, Meng T, Sun J, Boldogh I, Han Y, Brasier AR. Angiotensin II induces nuclear factor (NF)-kappaB1 isoforms to bind the angiotensinogen gene acute-phase response element (a stimulus-specific pathway for NF-kappaB activation). Mol Endocrinol. 2000;14:99–113
  13. Klett C, Nobiling R, Gierschik P, Hackenthal E. Angiotensin II stimulates the synthesis of angiotensinogen in hepatocytes by inhibiting adenylylcyclase activity and stabilizing angiotensinogen mRNA. J Biol Chem. 1993;268:25095–25107
  14. Lavoie L, Band CJ, Kong M, Bergeron JJM, Posner BI. Regulation of glycogen synthase in rat hepatocytes. Evidence for multiple signaling pathways. J Biol Chem. 1999;274:28279–28285
  15. Lazar DF, Wiese RJ, Brady MJ, Mastick CC, Waters SB, Yamauchi K, et al. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem. 1995;270:20801–20807
  16. Lieber CS, DeCarli LM. The feeding of alcohol in liquid diets (two decades of applications and 1982 update). Alcohol Clin Exp Res. 1982;6:523–531
  17. O'Rourke MF, Tuma DJ, Casey CA. Decreased binding and autophosphorylation of the epidermal growth factor receptor in ethanol-fed rats. Biochem Pharmacol. 1997;53:1445–1450
  18. Resnicoff M, Rubini M, Baserga R, Rubin R. Ethanol inhibits insulin-like growth factor-1-mediated signaling and proliferation of C6 rat glioblastoma cells. Lab Invest. 1994;71:657–662
  19. Rovinski, B., & Hosein, E. A. (1984). Chronic maternal ethanol administration in the rat decreases the stimulation by (-) epinephrine of glycogen phosphorylase a in the livers of the progeny during development. Subst Alcohol Actions Misuse 5, 77–85.
  20. Sandnes D, Dajani O, Bjorneby A, Christoffersen T. The relationship between activation of phosphoinositide-specific phospholipase C and growth stimulation by Ca2+-mobilizing hormones in hepatocytes. Pharmacol Toxicol. 1999;84:234–240
  21. Vlachogiannakos J, Tang AKW, Patch D, Burroughs AK. Angiotensin converting enzyme inhibitors and angiotensin II antagonists as therapy in chronic liver disease. Gut. 2001;49:303–308
  22. Weng Y, Shukla SD. Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes (agonist selectivity and ethanol metabolic independence). Eur J Pharmacol. 2000;398:323–331
  23. Weng Y-I, Shukla SD. Angiotensin II activation of focal adhesion kinase and pp60c-Srcin relation to mitogen-activated protein kinases in hepatocytes. Biochim Biophys Acta. 2002;1589:285–297
  24. Yang SQ, Lin HZ, Yin M, Albrecht JH, Diehl AM. Effects of chronic ethanol consumption on cytokine regulation of liver regeneration. Am J Physiol. 1998;275(4 Pt 1):G696–G704
  25. Zhang BH, Farrell GC. Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-γ1 (relevance to impaired hepatocyte proliferation). Biochem Biophys Res Commun. 1999;257:89–94
  26. Zhang SL, Chen X, Filep JG, Tang SS, Ingelfinger JR, Chan JS. Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells. Endocrinology. 1999;140:5285–5292

 Editor: T.R. Jerrells

PII: S0741-8329(02)00325-7

doi: 10.1016/S0741-8329(02)00325-7

Alcohol
Volume 29, Issue 2 , Pages 83-90 , February 2003