Alcohol
Volume 29, Issue 2 , Pages 101-108 , February 2003

Stable preference for high ethanol concentrations after ethanol deprivation in Sardinian alcohol-preferring (sP) rats

  • Salvatore Serra

      Affiliations

    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • C.N.R. Institute of Neurogenetics and Neuropharmacology, I-09042 Monserrato Cagliari, Italy
  • ,
  • Giuliana Brunetti

      Affiliations

    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • C.N.R. Institute of Neurogenetics and Neuropharmacology, I-09042 Monserrato Cagliari, Italy
  • ,
  • Giovanni Vacca

      Affiliations

    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • C.N.R. Institute of Neurogenetics and Neuropharmacology, I-09042 Monserrato Cagliari, Italy
  • ,
  • Carla Lobina

      Affiliations

    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • C.N.R. Institute of Neurogenetics and Neuropharmacology, I-09042 Monserrato Cagliari, Italy
  • ,
  • Mauro A.M. Carai

      Affiliations

    • Neuroscienze S.c.a r.l., I-09123 Cagliari, Italy
    • “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, I-09042 Monserrato Cagliari, Italy
  • ,
  • Gian Luigi Gessa
  • ,
  • Giancarlo Colombo

      Affiliations

    • C.N.R. Institute of Neurogenetics and Neuropharmacology, I-09042 Monserrato Cagliari, Italy
    • Corresponding Author InformationCorresponding author. C.N.R. Institute of Neurogenetics and Neuropharmacology, c/o “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, S.S. 554, km. 4.5, I-09042 Monserrato Cagliari, Italy. Tel.: +39-070-675-4325; fax: +39-070-675-4320

Received 3 June 2002 ,Revised 11 November 2002 ,Accepted 10 December 2002.

References 

  1. Agabio R, Carai MAM, Lobina C, Pani M, Reali R, Bourov I, et al. Dissociation of ethanol and saccharin preference in sP and sNP rats. Alcohol Clin Exp Res. 2000;24:24–29
  2. Agabio R, Carai MAM, Lobina C, Pani M, Reali R, Vacca G, et al. Development of short-lasting alcohol deprivation effect in Sardinian alcohol-preferring rats. Alcohol. 2000;21:59–62
  3. Bell RL, Rodd-Henricks ZA, Hsu CC, Murphy JM, Lumeng L, Li T-K, et al. Expression of an alcohol deprivation effect by alcohol non-preferring (NP) rats given concurrent access to multiple concentrations of ethanol. Alcohol Clin Exp Res. 2002;26(Suppl):61A
  4. Boening JA, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, et al. Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcohol Clin Exp Res. 2001;25(5 Suppl ISBRA):127S–131S
  5. Colombo G. Ethanol drinking behaviour in Sardinian alcohol-preferring rats. Alcohol Alcohol. 1997;32:443–453
  6. Colombo G, Agabio R, Diaz G, Fa M, Lobina C, Reali R, et al. Sardinian alcohol-preferring rats prefer chocolate and sucrose over ethanol. Alcohol. 1997;14:611–615
  7. Heyser CJ, Schulteis G, Koob GF. Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res. 1997;21:784–791
  8. Hölter SM, Engelmann M, Kirschke C, Liebsch G, Landgraf R, Spanagel R. Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behav Pharmacol. 1998;9:41–48
  9. Hölter SM, Linthorst ACE, Reul JMHM, Spanagel R. Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats. Pharmacol Biochem Behav. 2000;66:143–151
  10. Kampov-Polevoy AB, Matthews DB, Gause L, Morrow AL, Overstreet DH. P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking. Alcohol Clin Exp Res. 2000;24:278–284
  11. Koros E, Piasecki J, Kostowski W, Bienkowski P. Development of alcohol deprivation effect in rats: lack of correlation with saccharin drinking and locomotor activity. Alcohol Alcohol. 1999;34:542–550
  12. Lankford MF, Roscoe AK, Pennington SN, Myers RD. Drinking of high concentrations of ethanol versus palatable fluids in alcohol-preferring (P) rats: valid animal model of alcoholism. Alcohol. 1991;8:293–299
  13. Lumeng L, Hawkins TD, Li T-K. New strains of rats with alcohol preference and non-preference. In:  Thurman RG,  Williamson JR,  Drott H,  Chance B editor. Alcohol and Aldehyde Metabolizing Systems. Vol. 3:New York: Academic Press; 1977;p. 537–544
  14. McKinzie DL, Nowak KL, Yorger L, McBride WJ, Murphy JM, Lumeng L, et al. The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions. Alcohol Clin Exp Res. 1998;22:1170–1176
  15. Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, et al. Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats. Alcohol Clin Exp Res. 2001;25:1140–1150
  16. Rodd-Henricks ZA, McKinzie DL, Edmundson VE, Dagon CL, Murphy JM, McBride WJ, et al. Effects of 5-HT3 receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol. 2000;21:73–85
  17. Rodd-Henricks ZA, McKinzie DL, Murphy JM, McBride WJ, Lumeng L, Li T-K. The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations. Alcohol Clin Exp Res. 2000;24:747–753
  18. Rodd-Henricks ZA, McKinzie DL, Shaikh SR, Murphy JM, McBride WJ, Lumeng L, et al. Alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations. Alcohol Clin Exp Res. 2000;24:8–16
  19. Sinclair JD, Li T-K. Long and short alcohol deprivation: effects on AA and P alcohol-preferring rats. Alcohol. 1989;6:505–509
  20. Sinclair JD, Senter RJ. Increased preference for ethanol in rats following alcohol deprivation. Psychon Sci. 1967;8:11–12
  21. Sinclair JD, Tiihonen K. Lack of alcohol-deprivation effect in AA rats. Alcohol. 1988;5:85–87
  22. Vacca G, Serra S, Brunetti G, Carai MAM, Samson HH, Gessa GL, et al. Operant self-administration of ethanol in Sardinian alcohol-preferring rats. Alcohol Clin Exp Res. 2002;26:1678–1685
  23. Waller MB, McBride WJ, Lumeng L, Li T-K. Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats. Pharmacol Biochem Behav. 1982;16:501–507
  24. Wolffgramm J, Heyne A. From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res. 1995;70:77–94

PII: S0741-8329(03)00003-X

doi: 10.1016/S0741-8329(03)00003-X

Alcohol
Volume 29, Issue 2 , Pages 101-108 , February 2003