Alcohol
Volume 29, Issue 3 , Pages 183-186, April 2003

No acute effect of red wine on the coagulation pathway in healthy men☆

  • Pierre M van Golde

      Affiliations

    • Department of Internal Medicine, Meander Medical Center, P.O. Box 1502, 3800 BM Amersfoort, The Netherlands
    • ,
  • Rob J Kraaijenhagen

      Affiliations

    • Department of Clinical Chemistry, Meander Medical Center, 3800 BM Amersfoort, The Netherlands
    • ,
  • Bonno N Bouma

      Affiliations

    • Department of Hematology, University Medical Center, 3508 GA Utrecht, The Netherlands
    • ,
  • Albert van de Wiel

      Affiliations

    • Department of Internal Medicine, Meander Medical Center, P.O. Box 1502, 3800 BM Amersfoort, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31-33-4222444; fax: +31-33-4222695

Received 6 August 2002; received in revised form 7 January 2003; accepted 13 January 2003.

Editor: S. Borg

Abstract 

Binge drinking is associated with an increased risk of cardiovascular events. Those events often happen within hours after alcohol is consumed. Apart from arrhythmias and changes in blood pressure, these events may be caused by an acute (i.e., occurring within a 24-h period) shift of the hemostatic balance in a thrombogenic direction. Alcohol can influence platelet aggregation and inhibit fibrinolysis, but little is known about its direct effect on coagulation. In the current study, parameters of coagulation, reflecting either stimulation or inhibition, were measured 5 and 15 h after the consumption of four (62.5 g of alcohol) and eight (125 g of alcohol) glasses of red wine. Both doses had no direct effect on activated cephalin time, thrombin–antithrombin complexes, factors VII and VIII, and von Willebrand factor. In contrast with the observed effects on thrombocytes and fibrinolysis, the consumption of large amounts of wine does not influence the coagulation pathway.

Keywords:  Alcohol, Binge drinking, Coagulation, Hemostasis, Cardiovascular disease, Wine

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☆ In this article, the term acute—used in reference to, for example, a ‘shift in hemostatic balance, effect or effects on a phenomenon, and alcohol intake—reflects what is observed or occurs within a 24-h period. The term chronic—used in reference to alcohol consumption—reflects a pattern of drinking in terms of years but at least longer than 3 months.

PII: S0741-8329(03)00016-8

doi:10.1016/S0741-8329(03)00016-8

Alcohol
Volume 29, Issue 3 , Pages 183-186, April 2003

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