Alcohol
Volume 29, Issue 2 , Pages 117-124 , February 2003

Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area

  • Päivi Tuomainen

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, POB 33, 00251 Helsinki, Finland
    • ,
  • Anton Patsenka

      Affiliations

    • Institute of Biochemistry, National Academy of Sciences of Belarus, 50 BLK, Grodno 230017, Belarus
    • ,
  • Petri Hyytiä

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, POB 33, 00251 Helsinki, Finland
    • ,
  • Vladimir Grinevich

      Affiliations

    • Institute of Biochemistry, National Academy of Sciences of Belarus, 50 BLK, Grodno 230017, Belarus
    • ,
  • Kalervo Kiianmaa

      Affiliations

    • Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, POB 33, 00251 Helsinki, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358-9-4744-8111; fax: +358-9-4744-8133

Received 29 April 2002 ,Revised 23 December 2002 ,Accepted 13 January 2003.

References 

  1. Ahtee L, Eriksson K. Dopamine and noradrenaline content in the brain of rat strains selected for their alcohol intake. Acta Physiol Scand. 1975;93:563–565
  2. Brodie MS, Appel SB. The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcohol Clin Exp Res. 1998;22:236–244
  3. Brodie MS, Pesold C, Appel SB. Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcohol Clin Exp Res. 1999;23:1848–1852
  4. Carlsson A, Lindqvist M. Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo. J Pharm Pharmacol. 1973;25:437–440
  5. Di Chiara G. The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend. 1995;38:95–137
  6. Engel JA, Enerback C, Fahlke C, Hulthe P, Hård E, Johanessen K, et al. Serotonergic and dopaminergic involvement in ethanol intake. In:  Naranjo CA,  Sellers EM editor. Novel Pharmacological Interventions for Alcoholism. New York: Springer Verlag; 1992;p. 68–82
  7. Eriksson K. Genetic selection for voluntary alcohol consumption in the albino rat. Science. 1968;159:739–741
  8. Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G. Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res. 1985;348:201–203
  9. Gonzales RA, McNabb J, Yim HJ, Ripley T, Bungay PM. Quantitative microdialysis of ethanol in rat striatum. Alcohol Clin Exp Res. 1998;22:858–867
  10. Imperato A, Di Chiara G. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther. 1986;239:219–228
  11. Kiianmaa K, Hyytiä P, Sinclair JD. Development of an animal model of ethanol abuse: genetic approach. In:  Boulton AA,  Baker GB,  Wu PH editor. Animal Models of Drug Addiction, (Neuromethods Series - Vol. 24). Totowa, NJ: Humana Press; 1992;p. 29–63
  12. Kiianmaa K, Nurmi M, Nykänen I, Sinclair JD. Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats. Pharmacol Biochem Behav. 1995;52:29–34
  13. Kiianmaa K, Stenius K, Sinclair JD. Determinants of alcohol preference in the AA and ANA rat lines selected for differential ethanol intake. Alcohol Alcohol Suppl. 1991;1:115–120
  14. Kiianmaa K, Tabakoff B. Neurochemical correlates of tolerance and strain differences in the neurochemical effects of ethanol. Pharmacol Biochem Behav. 1983;18(Suppl 1):383–388
  15. Kiianmaa K, Tabakoff B. Catecholaminergic correlates of genetic differences in ethanol sensitivity. In:  Usdin E,  Carlsson A,  Dahlström A,  Engel J editor. Catecholamines (Part B: Neuropharmacology and Central Nervous System - Theoretical Aspects (Neurology and Neurobiology Series - Vol. 8)). New York: Alan R. Liss; 1984;p. 145–151
  16. Koob GF, Caine SB, Hyytiä P, Markou A, Parsons LH, Roberts AJ, et al. Neurobiology of drug addic-tion. In:  Glantz MD,  Hartel CR editor. Drug Abuse: Origins and Interventions. Washington, DC: American Psychological Association; 1999;p. 161–190
  17. Malila A. Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake. Pharmacol Biochem Behav. 1978;8:197–201
  18. Murphy JM, McBride WJ, Gatto GJ, Lumeng L, Li T-K. Effects of acute ethanol administration on monoamine and metabolite content in forebrain regions of ethanol-tolerant and -nontolerant alcohol-preferring (P) rats. Pharmacol Biochem Behav. 1988;29:169–174
  19. Nurmi M, Ashizawa T, Sinclair JD, Kiianmaa K. Effect of prior ethanol experience on dopamine overflow in accumbens of AA and ANA rats. Eur J Pharmacol. 1996;315:277–283
  20. Nurmi M, Kiianmaa K, Sinclair JD. Brain ethanol in AA, ANA, and Wistar rats monitored with one-minute microdialysis. Alcohol. 1994;11:315–321
  21. Nurmi M, Sinclair JD, Kiianmaa K. Dopamine release during ethanol drinking in AA rats. Alcohol Clin Exp Res. 1998;22:1628–1633
  22. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. San Diego, CA: Academic Press; 1998;
  23. Robinson DL, Lara JA, Brunner LJ, Gonzales RA. Quantification of ethanol concentrations in the extracellular fluid of the rat brain: in vivo calibration of microdialysis probes. J Neurochem. 2000;75:1685–1693
  24. Rodd-Henricks ZA, McKinzie DL, Crile RS, Murphy JM, McBride WJ. Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats. Psychopharmacology (Berl). 2000;149:217–224
  25. Sällström-Baum S, Hill R, Kiianmaa K, Rommelspacher H. Effect of ethanol on (R)- and (S)-salsolinol, salsoline, and THP in the nucleus accumbens of AA and ANA rats. Alcohol. 1999;18:165–169
  26. Sinclair JD, Lê AD, Kiianmaa K. The AA and ANA rat lines, selected for differences in voluntary alcohol consumption. Experientia. 1989;45:798–805
  27. Weiss F, Lorang MT, Bloom FE, Koob GF. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther. 1993;267:250–258
  28. Widdowson PS, Holman RB. Ethanol-induced increase in endogenous dopamine release may involve endogenous opiates. J Neurochem. 1992;59:157–163
  29. Wise RA. Drug-activation of brain reward pathways. Drug Alcohol Depend. 1998;51:13–22
  30. Wozniak KM, Pert A, Mele A, Linnoila M. Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study. Brain Res. 1991;540:31–40
  31. Yim HJ, Gonzales RA. Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition. Alcohol. 2000;22:107–115
  32. Yim HJ, Schallert T, Randall PK, Bungay PM, Gonzales RA. Effect of ethanol on extracellular dopamine in rat striatum by direct perfusion with microdialysis. J Neurochem. 1997;68:1527–1533
  33. Yim HJ, Schallert T, Randall PK, Gonzales RA. Comparison of local and systemic ethanol effects on extracellular dopamine concentration in rat nucleus accumbens by microdialysis. Alcohol Clin Exp Res. 1998;22:367–374
  34. Yoshimoto K, McBride WJ, Lumeng L, Li T-K. Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol. 1991;9:17–22
  35. Yoshimoto K, McBride WJ, Lumeng L, Li T-K. Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats. Alcohol Clin Exp Res. 1992;16:781–785

PII: S0741-8329(03)00017-X

doi: 10.1016/S0741-8329(03)00017-X

Alcohol
Volume 29, Issue 2 , Pages 117-124 , February 2003

Article Tools

* Image Usage & Resolution