Alcohol
Volume 29, Issue 2 , Pages 55-60 , February 2003

High-priority communication I Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

Received 26 August 2002 ,Revised 15 January 2003 ,Accepted 18 January 2003.

References 

  1. Andrews N, File SE. Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety. Eur J Pharmacol. 1993;235:109–112
  2. Annis HM, Sklar SM, Moser AE. Gender in relation to relapse crisis situations, coping, and outcome among treated alcoholics. Addict Behav. 1998;23:127–131
  3. Baldwin HA, Rassnick S, Rivier J, Koob GF, Britton KT. CRF antagonist reverses the “anxiogenic” response to ethanol withdrawal in the rat. Psychopharmacology (Berl). 1991;103:227–232
  4. Begleiter H, Porjesz B. Persistence of a “subacute withdrawal syndrome” following chronic ethanol intake. Drug Alcohol Depend. 1979;4:353–357
  5. Britton KT, Lee G, Dana R, Risch SC, Koob GF. Activating and ‘anxiogenic’ effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone. Life Sci. 1986;39:1281–1286
  6. Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science. 1987;236:410–416
  7. Cruz AP, Frei F, Graeff FG. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav. 1994;49:171–176
  8. De Soto CB, O'Donnell WE, Allred LJ, Lopes CE. Symptomatology in alcoholics at various stages of abstinence. Alcohol Clin Exp Res. 1985;9:505–512
  9. Dunn AJ, Berridge CW. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?. Brain Res Brain Res Rev. 1990;15:71–100
  10. Ehlers CL, Chaplin RI. Chronic ethanol exposure potentiates the locomotor-activating effects of corticotropin-releasing factor (CRF) in rats. Regul Pept. 1987;19:345–353
  11. Grant I, Reed R, Adams KM. Diagnosis of intermediate-duration and subacute organic mental disorders in abstinent alcoholics. J Clin Psychiatry. 1987;48:319–323
  12. Heinrichs SC, Menzaghi F, Pich EM, Baldwin HA, Rassnick S, Britton KT, et al. Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity. Neuropsychopharmacology. 1994;11:179–186
  13. Hershon HI. Alcohol withdrawal symptoms and drinking behavior. J Stud Alcohol. 1977;38:953–971
  14. Hölter SM, Engelmann M, Kirschke C, Liebsch G, Landgraf R, Spanagel R. Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behav Pharmacol. 1998;9:41–48
  15. Institute of Laboratory Animal Resources , Commission on Life Sciences , National Research Council . Guide for the Care and Use of Laboratory Animals. Washington: National Academy Press; 1996;
  16. Koob GF. Corticotropin-releasing factor, norepinephrine, and stress. Biol Psychiatry. 1999;46:1167–1180
  17. Koob GF, Heinrichs SC. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res. 1999;848:141–152
  18. Koob GF, Heinrichs SC, Menzaghi F, Pich EM, Britton KT. Corticotropin releasing factor, stress, and behavior. Semin Neurosci. 1994;6:221–229
  19. Koob GF, Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science. 1997;278:52–58
  20. Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology. 2001;24:97–129
  21. Menzaghi F, Howard RL, Heinrichs SC, Vale W, Rivier J, Koob GF. Characterization of a novel and potent corticotropin-releasing factor antagonist in rats. J Pharmacol Exp Ther. 1994;269:564–572
  22. Merlo-Pich E, Lorang M, Yeganeh M, Rodriguez de Fonseca F, Raber J, Koob GF, et al. Increase of extracellular corticotropin-releasing factor like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci. 1995;15:5439–5447
  23. Möller C, Wiklund L, Sommer W, Thorsell A, Heilig M. Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res. 1997;760:94–101
  24. Mormede P, Razafimanalina N, Courvoisier H, Ramos A, Berton O, Chaouloff F. QTLs for temperament traits in rats: relevance for alcohol drinking. (Abstract) Alcohol Clin Exp Res. 1998;22(Suppl):151A
  25. Pellegrino LJ, Pellegrino AS, Cushman AJ. A Stereotaxic Atlas of the Rat Brain. New York: Plenum Press; 1979;
  26. Pollard GT, Howard JL. Effects of drugs on punished behavior: pre-clinical test for anxiolytics. Pharmacol Ther. 1990;45:403–424
  27. Rasmussen DD, Mitton DR, Green J, Puchalski S. Chronic daily ethanol and withdrawal: 2. behavioral changes during prolonged abstinence. Alcohol Clin Exp Res. 2001;25:999–1005
  28. Rassnick S, Heinrichs SC, Britton KT, Koob GF. Micro-injection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res. 1993;605:25–32
  29. Richter RM, Weiss F. In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats. Synapse. 1999;32:254–261
  30. Roelofs SM. Hyperventilation, anxiety, craving for alcohol: a subacute alcohol withdrawal syndrome. Alcohol. 1985;2:501–505
  31. Schulteis G, Hyytia P, Heinrichs SC, Koob GF. Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats. Alcohol Clin Exp Res. 1996;20:164–171
  32. Slawecki CJ, Somes C, Ehlers CL. Effects of chronic ethanol exposure on neurophysiological responses to corticotropin-releasing factor and neuropeptide Y. Alcohol Alcohol. 1999;34:289–299
  33. Spina MG, Basso AM, Zorrilla EP, Heyser CJ, Rivier J, Vale W, et al. Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology. 2000;22:230–239
  34. Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, et al. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res. 2002;26:1494–1501
  35. Vale W, Rivier C, Brown MR, Spiess J, Koob G, Swanson L, et al. Chemical and biological characterization of corticotropin releasing factor. Recent Prog Horm Res. 1983;39:245–270
  36. Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981;213:1394–1397
  37. Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002;952:188–199
  38. Zorrilla EP, Valdez GR, Weiss F. Changes in levels of regional CRF-like immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats. Psychopharmacology (Berl). 2001;158:374–381

PII: S0741-8329(03)00020-X

doi: 10.1016/S0741-8329(03)00020-X

Alcohol
Volume 29, Issue 2 , Pages 55-60 , February 2003