Alcohol
Volume 29, Issue 3 , Pages 165-171 , April 2003

Blood ethanol concentration profiles: a comparison between rats and mice

  • Daniel J. Livy

      Affiliations

    • Division of Anatomy, Faculty of Medicine and Dentistry, 5.01 Medical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
  • ,
  • Scott E. Parnell

      Affiliations

    • Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center,College Station, TX 77843-1114, USA
  • ,
  • James R. West

      Affiliations

    • Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center,College Station, TX 77843-1114, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-979-845-4991; fax: +1-979-845-0790

Received 22 February 2002 ,Revised 17 February 2003 ,Accepted 17 February 2003.

References 

  1. Abel EL. Behavioral teratology of alcohol (animal model studies of the fetal alcohol syndrome). In:  Abel EL editors. Fetal Alcohol Syndrome, Vol. III. Animal Studies. Boca Raton, FL: CRC Press; 1982;p. 59–81
  2. Alcohol use and abuse: a pediatric concern. Pediatrics. 2001;108:185–189
  3. Balak KJ, Keith RH, Felder MR. Genetic and developmental regulation of mouse liver alcohol dehydrogenase. J Biol Chem. 1982;257:15000–15007
  4. Baraona E, Abittan CS, Dohmen K, Moretti M, Pozzato G, Chayes ZW, et al. Gender differences in pharmacokinetics of alcohol. Alcohol Clin Exp Res. 2001;25:502–507
  5. Bonthius DJ, Goodlett CR, West JR. Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration. Alcohol. 1988;5:209–214
  6. Bonthius DJ, Tzouras G, Karacay B, Mahoney J, Hutton A, McKim R, et al. Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. Dev Brain Res. 2002;138:45–59
  7. Bonthius DJ, West JR. Blood alcohol concentration and microencephaly: a dose-response study in the neonatal rat. Teratology. 1988;37:223–231
  8. Bonthius DJ, West JR. Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure. Alcohol Clin Exp Res. 1990;14:107–118
  9. Bossoni G, Colasanti P, Bianchi S, Riva M, Usardi MM. Influence of species specificity on gastric emptying rate and blood levels of carisoprodol. Pharmacol Res Commun. 1979;11:693–702
  10. Bourne DWA, Triggs EJ, Eadie MJ. Pharmacokinetics for the Non-Mathematical. Lancaster: MTP Press, Ltd; 1986;
  11. Crabb DW, Stein PM, Dipple KM, Hittle JB, Sidhu R, Qulali M, et al. Structure and expression of the rat class I alcohol dehydrogenase gene. Genomics. 1989;5:906–914
  12. Desiderio MA. Effects of acute, oral ethanol on cardiovascular performance before and after experimental blunt cardiac trauma. J Trauma. 1987;27:267–277
  13. Desiderio MA. Effect of rate of rise of blood alcohol on outcome of cardiac injury. J Trauma. 1988;28:765–771
  14. Desroches D, Orevillo C, Verina D. Sex- and strain-related differences in first-pass alcohol metabolism in mice. Alcohol. 1995;12:221–226
  15. DeWit DJ, Adlaf EM, Offord DR, Ogborne AC. Age at first alcohol use: a risk factor for the development of alcohol disorders. Am J Psychiatry. 2000;157:745–750
  16. Frezza M, di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med. 1990;322:95–99
  17. Keilin D, Hartree EF. Properties of catalase: catalysis of coupled oxidation of alcohols. Biochem J. 1945;39:293–301
  18. Kelly SJ, Bonthius DJ, West JR. Developmental changes in alcohol pharmacokinetics in rats. Alcohol Clin Exp Res. 1987;11:281–286
  19. Lieber CS. Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. New York: Plenum Press; 1992;
  20. Lieber CS. Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968–1998)—a review. Alcohol Clin Exp Res. 1999;23:991–1007
  21. Lieber CS. Ethnic and gender differences in ethanol metabolism. Alcohol Clin Exp Res. 2000;24:417–418
  22. Lieber CS, DeCarli LM. Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Science. 1968;162:917–918
  23. Lieber CS, DeCarli LM. Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. J Biol Chem. 1970;245:2505–2512
  24. Lim RT, Gentry RT, Ito D, Yokoyama H, Baraona E, Lieber CS. First-pass metabolism of ethanol is predominantly gastric. Alcohol Clin Exp Res. 1993;17:1337–1344
  25. Livy DJ, Maier SE, West JR. Long-term alcohol exposure prior to conception results in lower fetal body weights. Alcohol Clin Exp Res. 2001;25(Suppl):71A
  26. Middaugh LD, Frackelton WF, Boggan WO, Onofrio A, Shepherd CL. Gender differences in the effects of ethanol on C57BL/6 mice. Alcohol. 1992;9:257–260
  27. Ogilvie K, Lee S, Rivier C. Effect of three different modes of alcohol administration on the activity of the rat hypothalamic-pituitary-adrenal axis. Alcohol Clin Exp Res. 1997;21:467–476
  28. Ott JF, Hunter BE, Walker DW. The effect of age on ethanol metabolism and on the hypothermic and hypnotic responses to ethanol in the Fischer 344 rat. Alcohol Clin Exp Res. 1985;9:59–65
  29. Pan W-J, Hedaya MA. Cocaine and alcohol interactions in the rat: effect of cocaine and alcohol pretreatments on cocaine pharmacokinetics and pharmacodynamics. J Pharm Sci. 1999;88:1266–1274
  30. Pastino GM, Asgharian B, Roberts K, Medinsky MA, Bond JA. A comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats, and humans. Toxicol Appl Pharmacol. 1997;145:147–157
  31. Pastino GM, Sultatos LG, Flynn EJ. Development and application of a physiologically based pharmacokinetic model for ethanol in the mouse. Alcohol Alcohol. 1996;31:365–374
  32. Penton Z. Gas-chromatographic determination of ethanol in blood with 0.53-mm fused-silica open tubular columns. Clin Chem. 1987;33:2094–2095
  33. Pierce DR, West JR. Blood alcohol concentration: a critical factor for producing fetal alcohol effects. Alcohol. 1986;3:269–272
  34. Roine R, Gentry RT, Hernandez-Munoz R, Baraona E, Lieber CS. Aspirin increases blood alcohol concentrations in humans after ingestion of ethanol. JAMA. 1990;264:2406–2408
  35. Seitz HK, Egerer G, Simanowski UA, Waldherr R, Eckey R, Agarwal DP, et al. Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. Gut. 1993;34:1433–1437
  36. Smith ME. Interrelations in ethanol and methanol metabolism. J Pharmacol Exp Ther. 1961;134:233–237
  37. Sutherland I, Shepherd JP. The prevalence of alcohol, cigarette and illicit drug use in a stratified sample of English adolescents. Addiction. 2001;96:637–640
  38. Webster WS, Walsh DA, McEwen SE, Lipson AH. Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome. Teratology. 1983;27:231–243

PII: S0741-8329(03)00025-9

doi: 10.1016/S0741-8329(03)00025-9

Alcohol
Volume 29, Issue 3 , Pages 165-171 , April 2003