Alcohol
Volume 30, Issue 1 , Pages 19-28 , May 2003

Prenatal exposure to ethanol increases ethanol consumption: a conditioned response?

Received 15 November 2002 ,Revised 28 February 2003 ,Accepted 17 March 2003.

References 

  1. Abate P, Spear NE, Molina JC. Fetal and infantile alcohol-mediated associative learning in the rat. Alcohol Clin Exp Res. 2001;25:989–998
  2. Acquas E, Meloni M, Di Chiara G. Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release. Eur J Pharmacol. 1993;230:239–241
  3. Arnold HM, Robinson SR, Spear NE, Smotherman WP. Conditioned opioid activity in the rat fetus. Behav Neurosci. 1993;107:963–969
  4. Bannoura MD, Kraebel KS, Spear LP, Spear NE. Effects of preweanling ethanol odor exposure on ethanol preference. Alcohol. 1998;15:213–217
  5. Blass EM, Pedersen PE. Surgical manipulation of the uterine environment of rat fetuses. Physiol Behav. 1980;25:993–995
  6. Chotro MG, Alonso G. Stimulus preexposure reduces generalization of conditioned taste aversions between alcohol and nonalcohol flavors in infant rats. Behav Neurosci. 2003;117:113–122
  7. Chotro MG, Córdoba NE, Molina JC. Acute prenatal experience with alcohol in the amniotic fluid: interactions with aversive and appetitive alcohol orosensory learning in the rat pup. Dev Psychobiol. 1991;24:431–451
  8. Chotro MG, Kraebel KS, McKinzie DL, Molina JC, Spear N. Prenatal and postnatal ethanol exposure influences preweanling rats' behavioral and autonomic responding to ethanol odor. Alcohol. 1996;13:377–385
  9. Chotro MG, Molina JC. Acute ethanol contamination of the amniotic fluid during gestational day 21: postnatal changes in alcohol responsiveness in rats. Dev Psychobiol. 1990;23:535–547
  10. Chotro MG, Spear NE. Repeated exposure to moderate doses of alcohol in the rat fetus: evidence of sensitization to toxic and chemosensory aspects of alcohol. Alcohol Clin Exp Res. 1997;21:360–367
  11. Critcher EC, Lin CI, Patel J, Myers RD. Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone. Pharmacol Biochem Behav. 1983;18:225–229
  12. Domı́nguez HD, López MF, Chotro MG, Molina JC. Perinatal responsiveness to alcohol's chemosensory cues as a function of prenatal alcohol administration during gestational days 17–20 in the rat. Neurobiol Learn Mem. 1996;65:103–112
  13. Domı́nguez HD, López MF, Molina JC. Neonatal responsiveness to alcohol odor and infant intake as a function of alcohol experience during late gestation. Alcohol. 1998;16:109–117
  14. Ferraro FM, Hill KG, Kaczmarek HJ, Coonfield DL, Kiefer SW. Naltrexone modifies the palatability of basic tastes and alcohol in outbred male rats. Alcohol. 2002;27:107–114
  15. Goodwin FLW, Campisi M, Babinska I, Amit Z. Effects of naltrexone on the intake of ethanol and flavored solutions in rats. Alcohol. 2001;25:9–19
  16. Hall WG, Rosenblatt G. Suckling behavior and intake control in the developing rat pup. J Comp Physiol Psychol. 1977;91:1232–1247
  17. Hill KG, Kiefer SW. Naltrexone treatment increases the aversiveness of alcohol for outbred rats. Alcohol Clin Exp Res. 1997;21:637–641
  18. Hunt PS, Molina JC, Spear LP, Spear NE. Ethanol-mediated taste aversions and state-dependency in preweanling (16-day-old) rats. Behav Neural Biol. 1990;54:300–322
  19. Korthank AJ, Robinson SR. Effects of amniotic fluid on opioid activity and fetal responses to chemosensory stimuli. Dev Psychobiol. 1998;33:235–248
  20. Misanin JR, Blatt LA, Hinderliter CF. Age dependency in neophobia: its influence on taste-aversion learning and the flavor-preexposure effect in rats. Anim Learn Behav. 1985;13:69–76
  21. Molina JC, Chotro MG. Acute alcohol intoxication paired with appetitive reinforcement: effects upon ethanol intake in infant rats. Behav Neural Biol. 1989;51:326–345
  22. Molina JC, Chotro MG. Acute alcohol intoxication paired with aversive reinforcement: ethanol odor as a conditioned reinforcer in rat pups. Behav Neural Biol. 1989;52:1–19
  23. Molina JC, Chotro MG. Association between chemosensory stimuli and cesarean delivery in rat fetuses: neonatal presentation of similar stimuli increases motor activity. Behav Neural Biol. 1991;55:42–60
  24. Molina JC, Chotro MG, Domı́nguez HD. Fetal alcohol learning resulting from alcohol contamination of the prenatal environment. In:  Lecanuet JP,  Fifer WP,  Krasnegor NA,  Smotherman WP editor. Fetal Development: A Psychobiological Perspective. Hillsdale, NJ: Lawrence Erlbaum Associates; 1995;p. 419–438
  25. Molina JC, Chotro MG, Spear NE. Early (preweanling) recognition of alcohol's orosensory cues resulting from acute ethanol intoxication. Behav Neural Biol. 1989;51:307–325
  26. Molina JC, Serwatka J, Spear NE. Changes in alcohol intake resulting from prior experiences with alcohol odor in young rats. Pharmacol Biochem Behav. 1984;21:387–391
  27. Pedersen P, Greer C, Shepherd G. Early development of olfactory function. In:  Blass EM editors. Handbook of Behavioral Neurobiology, Vol. 8. Vol. 8:New York: Plenum Press; 1986;p. 163–203
  28. Pedersen PE, Stewart WB, Greer CA, Shepherd GM. Evidence for olfactory function in utero. Science. 1983;221:478–480
  29. Reid LD, Hunter GA, Beaman CM, Hubbell CL. Toward understanding ethanol's capacity to be reinforcing: a conditioned place preference following injections of ethanol. Pharmacol Biochem Behav. 1985;22:483–487
  30. Roberts AJ, McDonald JS, Heyser CJ, Kieffer BL, Matthes HWD, Koob GF, et al. mu-Opioid receptor knockout mice do not self-administer alcohol. J Pharmacol Exp Ther. 2000;293:1002–1008
  31. Robinson DL, Brunner LJ, Gonzales RA. Effect of gender and estrous cycle on the pharmacokinetics of ethanol in the rat brain. Alcohol Clin Exp Res. 2002;26:165–172
  32. Smotherman WP. In utero chemosensory experience alters taste preferences and corticosterone responsiveness. Behav Neural Biol. 1982;36:61–68
  33. Smotherman WP. Odor aversion learning by the rat fetus. Physiol Behav. 1982;29:769–771
  34. Smotherman WP. Classical conditioning in the rat fetus: involvement of mu and kappa opioid systems in the conditioned response. Dev Psychobiol. 2002;40:104–115
  35. Smotherman WP. Classical conditioning in the rat fetus: temporal characteristics and behavioral correlates of the conditioned response. Dev Psychobiol. 2002;40:116–130
  36. Smotherman WP, Robinson SR. The rat fetus in its environment: behavioral adjustments to novel, familiar, aversive, and conditioned stimuli presented in utero. Behav Neurosci. 1985;99:521–530
  37. Smotherman WP, Robinson SR. Behavior of rat fetuses following chemical or tactile stimulation. Behav Neurosci. 1988;102:24–34
  38. Smotherman WP, Robinson SR. The uterus as environment: the ecology of fetal behavior. In:  Blass EM editors. Handbook of Behavioral Neurobiology, Vol. 9. Vol. 9:New York: Plenum Press; 1988;p. 149–196
  39. Smotherman WP, Robinson SR. The prenatal origins of behavioral organization. Psychol Sci. 1990;1:97–106
  40. Smotherman WP, Robinson SR. Habituation and classical conditioning in the rat fetus: opioid involvements. In:  Lecanuet JP,  Fifer WP,  Krasnegor NA,  Smotherman WP editor. Fetal Development: A Psychobiological Perspective. Hillsdale, NJ: Lawrence Erlbaum Associates; 1995;p. 295–314
  41. Smotherman WP, Simonik DK, Andersen SL, Robinson SR. Mu and kappa opioid systems modulate responses to cutaneous perioral stimulation in the fetal rat. Physiol Behav. 1993;53:751–756
  42. Stickrod G, Kimble DP, Smotherman WP. In utero taste/odor aversion conditioning in the rat. Physiol Behav. 1982;28:5–7
  43. Stromberg MF, Casale M, Volpicelli L, Volpicelli JR, O'Brien CP. A comparison of the effects of the opioid antagonists naltrexone, naltrindole and β-funaltrexamine on ethanol consumption in the rat. Alcohol. 1998;15:281–289
  44. Szeto HH. Maternal–fetal pharmacokinetics and fetal doseresponse relationships. Ann N Y Acad Sci. 1989;562:42–55
  45. Teicher MH, Blass EM. First suckling response of the newborn albino rat: the roles of olfaction and amniotic fluid. Science. 1977;198:635–636
  46. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry. 1992;49:876–880
  47. Wu M-F. Naloxone reduces fluid consumption: relationship of this effect to conditioned taste aversion and morphine dependence. Bull Psychon Soc. 1979;14:323–325

PII: S0741-8329(03)00037-5

doi: 10.1016/S0741-8329(03)00037-5

Alcohol
Volume 30, Issue 1 , Pages 19-28 , May 2003

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