Alcohol
Volume 30, Issue 1 , Pages 81-85, May 2003

Circadian activity rhythms in high-alcohol-preferring and low-alcohol-preferring mice

  • John R Hofstetter

      Affiliations

    • Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    • Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • Corresponding Author InformationCorresponding author. 116A, Roudebush Department of Veterans Affairs Medical Center, Indianapolis, IN 46202, USA. Tel.: +1-317-554-0000, ext. 4510; fax: +1-317-554-0056
    • ,
  • Nicholas J Grahame

      Affiliations

    • Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • ,
  • Aimee R Mayeda

      Affiliations

    • Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    • Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Received 6 September 2002; received in revised form 21 April 2003; accepted 3 May 2003.

Editor: T.R. Jerrells

Abstract 

The circadian periods of high-alcohol-preferring (HAP) and low-alcohol-preferring (LAP) selected lines of mice were compared. The mice were ethanol-naive. Circadian periods were calculated from records of running-wheel activity in constant dark. The number of daily wheel revolutions and body weights of the two lines of mice were also compared. The HAP line had a shorter period of wheel running than that of the LAP lines. The HAP mice also had a tendency to run more on wheels than did LAP mice. These findings support the suggestion that genes affecting ethanol consumption in mice have pleiotropic effects on circadian period.

Keywords:  Wheel-running, Daily rhythm, Locomotor activity, Free-running period, Selected lines, Drugs of abuse

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PII: S0741-8329(03)00095-8

doi:10.1016/S0741-8329(03)00095-8

Alcohol
Volume 30, Issue 1 , Pages 81-85, May 2003

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