Alcohol
Volume 30, Issue 3 , Pages 193-200 , July 2003

Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study

  • Ronald E Dahl

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    • ,
  • Douglas E Williamson

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-412-624-4526; fax: +1-412-624-0223.
    • ,
  • Michele A Bertocci

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    • ,
  • Mary V Stolz

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    • ,
  • Neal D Ryan

      Affiliations

    • Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    • ,
  • Cindy L Ehlers

      Affiliations

    • Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, CVN-14, La Jolla, CA 92037, USA

Received 10 December 2002 ,Revised 28 May 2003 ,Accepted 4 June 2003.

References 

  1. Alper KR, Chabot RJ, Kim AH, Prichep LS, John ER. Quantitative EEG correlates of crack cocaine dependence. Psychiatry Res. 1990;35:95–105
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. (3rd ed. revised). Washington, DC: Author; 1987;
  3. Bauer LO, Hesselbrock VM. EEG, autonomic and subjective correlates of the risk for alcoholism. J Stud Alcohol. 1993;54:577–589
  4. Bauer LO, Hesselbrock VM. Lateral asymmetries in the frontal brain: effects of depression and a family history of alcoholism in female adolescents. Alcohol Clin Exp Res. 2002;26:1662–1668
  5. Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992;49:651–668
  6. Birmaher B, Dahl RE, Williamson DE, Perel JM, Brent DA, Axelson DA, et al. Growth hormone secretion in children and adolescents at high risk for major depressive disorder. Arch Gen Psychiatry. 2000;57:867–872
  7. Brower KJ. Alcohol's effects on sleep in alcoholics. Alcohol Res Health. 2001;25:110–125
  8. Brower KJ, Aldrich MS, Hall JM. Polysomnographic and subjective sleep predictors of alcoholic relapse. Alcohol Clin Exp Res. 1998;22:1864–1871
  9. Brower KJ, Aldrich MS, Robinson EAR, Zuker RA, Greden JF. Insomnia, self-medication, and relapse to alcoholism. Am J Psychiatry. 2001;158:399–404
  10. Clark CP, Gillin JC, Golshan S, Demodena A, Smith TL, Danowski S, et al. Increased REM sleep density at admission predicts relapse by three months in primary alcoholics with a lifetime diagnosis of secondary depression. Biol Psychiatry. 1998;43:601–607
  11. Cohen HL, Porjesz B, Begleiter H. EEG characteristics in males at risk for alcoholism. Alcohol Clin Exp Res. 1991;15:858–861
  12. Cohen J. Statistical Power Analysis for the Behavioral Sciences. (2nd ed.). Mahwah, NJ: Lawrence Erlbaum Associates; 1988;
  13. Costa L, Bauer L. Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence. Drug Alcohol Depend. 1997;46:87–93
  14. Dahl RE, Birmaher B, Williamson DE, Dorn L, Perel J, Kaufman J, et al. Low growth hormone response to growth hormone–releasing hormone in child depression. Biol Psychiatry. 2000;48:981–988
  15. Dahl RE, Ryan ND, Birmaher B, al-Shabbout M, Williamson DE, Neidig M, et al. Electroencephalographic sleep measures in prepubertal depression. Psychiatry Res. 1991;38:201–214
  16. Dahl RE, Ryan ND, Matty MK, Birmaher B, al-Shabbout M, Williamson DE, et al. Sleep onset abnormalities in depressed adolescents. Biol Psychiatry. 1996;39:400–410
  17. Devor EJ, Cloninger CR. Genetics of alcoholism. Annu Rev Genet. 1989;23:19–36
  18. Drummond SP, Gillin JC, Smith TL, DeModena A. The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse. Alcohol Clin Exp Res. 1998;22:1796–1802
  19. Ehlers CL. Alcohol and sleep. In: Review of NIAAA's Neuroscience and Behavioral Research Portfolio. Washington, DC: NIAAA; 2000;p. 417–433 Research Monograph No. 34
  20. Ehlers CL, Chaplin RI. EEG and ERP response to chronic ethanol exposure in rats. Psychopharmacology (Berl). 1991;104:67–74
  21. Ehlers CL, Garcia-Andrade C, Wall TL, Cloutier D, Phillips E. Electroencephalographic responses to alcohol challenge in Native American Mission Indians. Biol Psychiatry. 1999;45:776–787
  22. Ehlers CL, Havstad JW. Characterization of drug effects on the EEG by power spectral band time series analysis. Psychopharmacol Bull. 1982;18:43–47
  23. Ehlers CL, Kaneko WM, Wall TL, Chaplin RI. Effects of dizocilpine (MK-801) and ethanol on the EEG and event-related potentials (ERPS) in rats. Neuropharmacology. 1992;31:369–378
  24. Ehlers CL, Kupfer DJ. Effects of age on delta and REM sleep parameters. Electroencephalogr Clin Neurophysiol. 1989;72:118–125
  25. Ehlers CL, Kupfer DJ, Buysse DJ, Cluss PA, Miewald JM, Bisson EF, et al. The Pittsburgh study of normal sleep in young adults: focus on the relationship between waking and sleeping EEG spectral patterns. Electroencephalogr Clin Neurophysiol. 1998;106:199–205
  26. Ehlers CL, Phillips E. EEG low-voltage alpha and alpha power in African American young adults: relation to family history of alcoholism. Alcohol Clin Exp Res. 2003;27:765–772
  27. Ehlers CL, Phillips E, Parry BL. Electrophysiological findings during the menstrual cycle in women with and without late luteal phase dysphoric disorder: relationship to risk for alcoholism?. Biol Psychiatry. 1996;39:720–732
  28. Ehlers CL, Schuckit MA. EEG response to ethanol in sons of alcoholics. Psychopharmocol Bull. 1988;24:434–437
  29. Ehlers CL, Schuckit MA. EEG fast frequency activity in the sons of alcoholics. Biol Psychiatry. 1990;27:631–641
  30. Ehlers CL, Schuckit MA. Evaluation of EEG alpha activity in sons of alcoholics. Neuropsychopharmacology. 1991;4:199–205
  31. Ehlers CL, Slawecki CJ. Effects of chronic ethanol exposure on sleep in rats. Alcohol. 2000;20:173–179
  32. Ehlers CL, Wall TL, Schuckit MA. EEG spectral characteristics following ethanol administration in young men. Electroencephalogr Clin Neurophysiol. 1989;73:179–187
  33. Finn PR, Justus A. Reduced EEG alpha power in the male and female offspring of alcoholics. Alcohol Clin Exp Res. 1999;23:256–262
  34. Foster JH, Peters TJ. Impaired sleep in alcohol misusers and dependent alcoholics and the impact upon outcome. Alcohol Clin Exp Res. 1999;23:1044–1051
  35. Gabrielli WF, Mednick SA, Volavka J, Pollock VE, Schulsinger F, Itil TM. Electroencephalograms in children of alcoholic fathers. Psychophysiology. 1982;19:404–407
  36. Gillin JC, Smith TL, Irwin M, Butters N, Demodena A, Schuckit M. Increased pressure for rapid eye movement sleep at time of hospital admission predicts relapse in nondepressed patients with primary alcoholism at 3-month follow-up. Arch Gen Psychiatry. 1994;51:189–197
  37. Gillin JC, Smith TL, Irwin M, Kripke DF, Brown S, Schuckit M. Short REM latency in primary alcoholic patients with secondary depression. Am J Psychiatry. 1990;147:106–109
  38. Gillin JC, Smith TL, Irwin M, Kripke DF, Schuckit M. EEG sleep studies in “pure” primary alcoholism during subacute withdrawal: relationships to normal controls, age, and other clinical variables. Biol Psychiatry. 1990;27:477–488
  39. Goldman D. Recent developments in alcoholism: genetic transmission. Recent Dev Alcohol. 1993;11:231–248
  40. Irwin M, Miller C, Gillin JC, Demodena A, Ehlers CL. Polysomnographic and spectral sleep EEG in primary alcoholics: an interaction between alcohol dependence and African-American ethnicity. Alcohol Clin Exp Res. 2000;24:1376–1384
  41. Johnson JE. Insomnia, alcohol, and over-the-counter drug use in old-old urban women. J Community Health Nurs. 1997;14:181–188
  42. Kupfer DJ, Ehlers CL. Two roads to rapid eye movement latency. Arch Gen Psychiatry. 1989;46:945–948
  43. Kupfer DJ, Foster FG. The sleep of psychotic patients: does it all look alike?. Res Publ Assoc Res Nerv Ment Dis. 1975;54:143–164
  44. Pollock VE, Earleywine M, Gabrielli WF. Personality and EEG beta in older adults with alcoholic relatives. Alcohol Clin Exp Res. 1995;19:37–43
  45. Prichep LS, Alper KR, Kowalik S, Merkin H, Tom M, John ER, et al. Quantitative electroencephalographic characteristics of crack cocaine dependence. Biol Psychiatry. 1996;40:986–993
  46. Propping P, Kruger J, Mark N. Genetic disposition to alcoholism. An EEG study in alcoholics and their relatives. Hum Genet. 1981;59:51–59
  47. Rao U, Ryan ND, Dahl RE, Birmaher B, Rao R, Williamson DE, et al. Factors associated with the development of substance use disorder in depressed adolescents. J Am Acad Child Adolesc Psychiatry. 1999;38:1109–1117
  48. In:  Rechtschaffen A,  Kales A editor. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Los Angeles: Brain Information Service/Brain Research Institute, University of California; 1968;
  49. Roemer RA, Cornwell A, Dewart D, Jackson P, Ercegovac DV. Quantitative electroencephalographic analyses in cocaine-preferring polysubstance abusers during abstinence. Psychiatry Res. 1995;58:247–257
  50. Ryan ND, Dahl RE, Birmaher B, Williamson DE, Iyengar S, Nelson B, et al. Stimulatory tests of growth hormone secretion in prepubertal major depression: depressed versus normal children. J Am Acad Child Adolesc Psychiatry. 1994;33:824–833
  51. Schuckit MA. Genetics and the risk for alcoholism. JAMA. 1985;254:2614–2617
  52. Sher JK. Children of Alcoholics: A Critical Appraisal of Theory and Research. Chicago: University of Chicago Press; 1991;
  53. Slawecki CJ, Somes C, Ehlers CL. Effects of chronic ethanol exposure on neurophysiological responses to corticotropin-releasing factor and neuropeptide Y. Alcohol Alcohol. 1999;34:289–299
  54. Spitzer RL, Endicott J, Robins E. Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry. 1978;35:773–782
  55. Wechsler D. The Wechsler Intelligence Scale for Children (WISC). San Antonio, TX: Psychological Corporation; 1974;
  56. West MO, Prinz RJ. Parental alcoholism and childhood psychopathology. Psychol Bull. 1987;102:204–218
  57. Williamson DE, Dahl RE, Birmaher B, Goetz RR, Nelson B, Ryan ND. Stressful life events and EEG sleep in depressed and normal control adolescents. Biol Psychiatry. 1995;37:859–865
  58. Williamson DE, Ryan ND, Dahl RE, Jeannette L. Hamilton depression scores can be extracted from the K-SADS-P in adolescents. J Child Adolesc Psychopharmacol. 1992;2:175–181

PII: S0741-8329(03)00138-1

doi: 10.1016/j.alcohol.2003.06.001

Alcohol
Volume 30, Issue 3 , Pages 193-200 , July 2003

Article Tools