Alcohol
Volume 31, Issue 1 , Pages 31-38 , August 2003

Ethanol increases phosphodiesterase 4 activity in bovine bronchial epithelial cells

  • Mary A. Forgèt

      Affiliations

    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE, 68198-5300, USA
    • ,
  • Joseph H. Sisson

      Affiliations

    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE, 68198-5300, USA
    • ,
  • John R. Spurzem

      Affiliations

    • Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE, 68198-5300, USA
    • ,
  • Todd A. Wyatt

      Affiliations

    • Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    • Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE, 68198-5300, USA
    • Corresponding Author InformationCorresponding author. Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE, 68198-5300, USA. Tel.: +1-402-559-3817; fax: 1-402-559-8210.

Received 13 March 2003 ,Revised 14 June 2003 ,Accepted 20 June 2003.

References 

  1. Barnes PJ. Cyclic nucleotides and phosphodiesterases and airway function. Eur Respir J. 1995;8:457–462
  2. Beavo JA, Conti M, Heaslip RJ. Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol. 1994;46:399–405
  3. Belleville J. The French paradox: possible involvement of ethanol in the protective effect against cardiovascular diseases. Nutrition. 2002;18:173–177
  4. Francis SH, Turko IV, Corbin JD. Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol. 2001;65:1–52
  5. Fuhrmann M, Jahn H-U, Seybold J, Neurohr C, Barnes PJ, Hippenstiel S, et al. Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells. Am J Respir Cell Mol Biol. 1999;20:292–302
  6. Guidot DM, Roman J. Chronic ethanol ingestion increases susceptibility to acute lung injury: role of oxidative stress and tissue remodeling. Chest. 2002;122(6 Suppl):309S–314S
  7. Harper JF, Brooker G. Alcohol potentiation of isoproterenol-stimulated cyclic AMP accumulation in rat parotid. J Cyclic Nucleotide Res. 1980;6:51–62
  8. Jain B, Rubinstein I, Robbins RA, Leise KL, Sisson JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun. 1993;191:83–88
  9. Jiang H, Colbran JL, Francis SH, Corbin JD. Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem. 1992;267:1015–1019
  10. Karppanen H, Puurunen J, Kairaluoma M, Larmi T. Effects of ethyl alcohol on the adenosine 3′,5′-monophosphate system of the human gastric mucosa. Scand J Gastroenterol. 1976;11:603–607
  11. Kultgen PL, Byrd SK, Ostrowski LE, Milgram SL. Characterization of an A-kinase anchoring protein in human ciliary axonemes. Mol Biol Cell. 2002;13:4156–4166
  12. Lansley AB, Sanderson MJ, Dirksen ER. Control of the beat cycle of respiratory tract cilia by Ca2+ and cAMP. Am J Physiol. 1992;263(2 Pt 1):L232–L242
  13. Lebowitz MD. Respiratory symptoms and disease related to alcohol consumption. Am Rev Resp Dis. 1981;123:16–19
  14. Li D, Shirakami G, Zhan X, Johns RA. Regulation of ciliary beat frequency by the nitric oxide–cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells. Am J Respir Cell Mol Biol. 2000;23:175–181
  15. Murray RP, Istvan JA, Daniels K, Beaudoin CM. Alcohol and morbidity in the Lung Health Study. J Stud Alcohol. 1998;59:250–257
  16. Potter JJ, MacDougald OA, Mezey E. Regulation of rat alcohol dehydrogenase by cyclic AMP in primary hepatocyte culture. Arch Biochem Biophys. 1995;321:329–335
  17. Redmond EM, Sitzmann JV, Cahill PA. Potential mechanisms for cardiovascular protective effect of ethanol. Acta Pharmacol Sin. 2000;21:385–390
  18. Sisson JH. Ethanol stimulates apparent nitric oxide–dependent ciliary beat frequency in bovine airway epithelial cells. Am J Physiol. 1995;268(4 Pt 1):L596–L600
  19. Sisson JH, May K, Wyatt TA. Nitric oxide–dependent ethanol stimulation of ciliary motility is linked to cAMP-dependent protein kinase (PKA) activation in bovine bronchial epithelium. Alcohol Clin Exp Res. 1999;23:1528–1533
  20. Sisson JH, Mommsen J, Spurzem JR, Wyatt TA. Localization of PKA and PKG in bovine bronchial epithelial cells and axonemes. Am J Respir Crit Care Med. 2000;161:449A; (Abstract)
  21. Soderling SH, Beavo JA. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol. 2000;12:174–179
  22. Suzuki N, Tanaka H, Arima M. [Activity of 2′,3′-cyclic nucleotide 3′-phosphohydrolase in the central nervous system of rat fetal alcohol syndrome during development (author's transl)]. No To Shinkei. 1981;33:1207–1212
  23. Tabak C, Smit HA, Rasanen L, Fidanza F, Menotti A, Nissinen A, et al. Alcohol consumption in relation to 20-year COPD mortality and pulmonary function in middle-aged men from three European countries. Epidemiology. 2001;12:239–245
  24. Wyatt TA, Naftilan AJ, Francis SH, Corbin JD. ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells. Am J Physiol. 1998;274(2 Pt 2):H448–H455
  25. Wyatt TA, Sisson JH. Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2001;281:L575–L581
  26. Wyatt TA, Spurzem JR, May K, Sisson JH. Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells. Am J Physiol. 1998;275(4 Pt 1):L827–L835
  27. Zakaroff-Girard A, El Bawab S, Nemoz G, Lagarde M, Prigent AF. Relationships between phosphatidic acid and cyclic nucleotide phosphodiesterases in activated human blood mononuclear cells. J Leukoc Biol. 1999;65:381–390

PII: S0741-8329(03)00164-2

doi: 10.1016/j.alcohol.2003.06.005

Alcohol
Volume 31, Issue 1 , Pages 31-38 , August 2003

Article Tools

* Image Usage & Resolution