Alcohol
Volume 31, Issue 1 , Pages 63-69 , August 2003

Acetaldehyde-reinforcing effects: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats

Received 5 May 2003 ,Revised 1 July 2003 ,Accepted 6 July 2003.

References 

  1. Agarwal DP, Goedde HW. Human aldehyde dehydrogenases: their role in alcoholism. Alcohol. 1989;6:517–523
  2. Brown ZW, Amit Z, Rockman GE. Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats. Psychopharmacology (Berl). 1979;64:271–276
  3. Brown ZW, Amit Z, Smith B. Intraventricular self-administration of acetaldehyde and voluntary consumption of ethanol in rats. Behav Neural Biol. 1980;28:150–155
  4. Brown ZW, Amit Z, Smith B, Rockman GE. Differential effects on conditioned taste aversion learning with peripherally and centrally administered acetaldehyde. Neuropharmacology. 1978;17:931–935
  5. Cassel JC, Pacteau C, Will BE. Ethanol intoxication fails to affect sprouting induced entorhinal cortex lesions. Alcohol. 1987;4:367–372
  6. Davis VE, Walsh MJ. Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction. Science. 1970;167:1005–1007
  7. Dewey SL, West JR. Organization of the commissural projection to the dentate gyrus is unaltered by heavy ethanol exposure during gestation. Alcohol. 1985;2:617–622
  8. Duncan CC, Fernando PW. Effects of tetrahydropapaveroline in the nucleus accumbens and the ventral tegmental area on ethanol preference in the rat. Alcohol. 1991;8:87–90
  9. Eriksson CJP. Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference. Biochem Pharmacol. 1973;22:2283–2292
  10. Eriksson CJP, Marselos M, Koivula T. Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo. Biochem J. 1975;152:709–712
  11. Eriksson CJP, Sippel HW, Forsander OA. The determination of acetaldehyde in biological samples by head-space gas chromatography. Anal Biochem. 1977;80:116–124
  12. Eriksson K. Genetic selection for voluntary alcohol consumption in the albino rat. Science. 1968;159:739–741
  13. Giovine A, Renis M, Bertolino A. In vivo and in vitro studies on the effect of tetrahydropapaveroline and salsolinol on COMT and MAO activity in rat brain. Pharmacology. 1976;14:86–94
  14. Heikkila R, Cohen G, Dembiec D. Tetrahydroisoquinoline alkaloids: uptake by rat brain homogenates and inhibition of catecholamine uptake. J Pharmacol Exp Ther. 1971;179:250–258
  15. Hunt WA. Role of acetaldehyde in the actions of ethanol on the brain—a review. Alcohol. 1996;13:147–151
  16. Koivisto T, Eriksson CJP. Hepatic aldehyde and alcohol dehydrogenases in alcohol-preferring and alcohol-avoiding rat lines. Biochem Pharmacol. 1994;48:1551–1558
  17. Koivula T, Koivusalo M, Lindros KO. Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preference. Biochem Pharmacol. 1975;24:1807–1811
  18. Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci. 1992;13:177–184
  19. Mardones J, Segovia-Riquelme N. Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav Toxicol Teratol. 1983;5:171–178
  20. McBride WJ, Li T-K, Deitrich RA, Zimatkin S, Smith BR, Rodd-Henricks ZA. Involvement of acetaldehyde in alcohol addiction. Alcohol Clin Exp Res. 2002;26:114–119
  21. Mizoi Y, Taisuno Y, Adachi J, Kogame M, Fukunaga T, Fujiwara S, et al. Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese. Pharmacol Biochem Behav. 1983;18(Suppl 1):127–133
  22. Myers RD. Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism. Alcohol Clin Exp Res. 1978;2:145–154
  23. Myers RD, Melchior CL. Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain. Science. 1977;196:554–556
  24. Paez X, Myers RD. Alcohol-induced poikilothermia sleep and motor impairment: actions on brain of EGTA and verapamil. Alcohol. 1989;6:489–498
  25. Peng GS, Wang MF, Chen CY, Luu SU, Chou HC, Li T-K, et al. Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics. 1999;9:463–476
  26. Quertemont E, De Witte P. Conditioned stimulus preference after acetaldehyde but not ethanol injections. Pharmacol Biochem Behav. 2001;68:449–454
  27. Quintanilla ME, Callejas O, Tampier L. Aversion to acetaldehyde: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats. Alcohol. 2002;26:69–74
  28. Quintanilla ME, Tampier L. Acetaldehyde metabolism by brain mitochondria from UChA and UChB rats. Alcohol. 1995;12:519–524
  29. Sapag A, Tampier L, Valle-Prieto A, Quintanilla ME, Moncada C, Israel Y. Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats. Pharmacogenetics. 2003;13:509–515
  30. Smith BR, Amit Z, Splawinsky J. Conditioned place preference induced by intraventricular infusions of acetaldehyde. Alcohol. 1984;1:193–195
  31. Socaransky SM, Aragon CMG, Amit Z, Blander A. Higher correlation of ethanol consumption with brain than liver aldehyde dehydrogenase in three strains of rats. Psychopharmacology (Berl). 1984;84:250–253
  32. Tabakoff B, Anderson RA, Ritzmann RF. Brain acetaldehyde after ethanol administration. Biochem Pharmacol. 1976;25:1305–1309
  33. Tampier L, Quintanilla ME, Mardones J. Effect of nicotinamide administration on ethanol consumption and on liver and brain acetaldehyde oxidation rate by UChB rats. Addict Biol. 1999;4:191–195
  34. Tampier L, Sanchez E, Quintanilla ME. Acetaldehyde metabolism by liver mitochondrial ALDH from UChA and UChB rats: effect of inhibitors. Addict Biol. 1996;1:379–384
  35. Teng YS. Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: gene deletion and its possible implications in alcohol metabolism. Biochem Genet. 1981;19:107–114
  36. Tu GC, Israel Y. Alcohol consumption by Orientals in North America is predicted largely by a single gene. Behav Genet. 1995;25:59–65
  37. Yoshida A, Huang IY, Ikawa M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A. 1984;81:258–261
  38. Yoshida A, Ikawa M, Hsu LC, Tani K. Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. Alcohol. 1985;2:103–106

PII: S0741-8329(03)00188-5

doi: 10.1016/j.alcohol.2003.07.001

Alcohol
Volume 31, Issue 1 , Pages 63-69 , August 2003

Article Tools

* Image Usage & Resolution