Alcohol
Volume 31, Issue 1 , Pages 71-76 , August 2003

Ethanol inhibition of recombinant NR1/2A receptors: effects of heavy metal chelators and a zinc-insensitive NR2A mutant

Received 28 April 2003 ,Revised 10 July 2003 ,Accepted 14 July 2003.

References 

  1. Anders DL, Blevins T, Smothers CT, Woodward JJ. Reduced ethanol inhibition of N-methyl-d-aspartate receptors by deletion of the NR1 C0 domain or overexpression of α-actinin-2 proteins. J Biol Chem. 2000;275:15019–15024
  2. Blevins T, Mirshahi T, Chandler LJ, Woodward JJ. Effects of acute and chronic ethanol exposure on heteromeric N-methyl-d-aspartate receptors expressed in HEK 293 cells. J Neurochem. 1997;69:2345–2354
  3. Buller AL, Larson HC, Morrisett RA, Monaghan DT. Glycine modulates ethanol inhibition of heteromeric N-methyl-d-aspartate receptors expressed in Xenopus oocytes. Mol Pharmacol. 1995;48:717–723
  4. Chen N, Moshaver A, Raymond LA. Differential sensitivity of recombinant N-methyl-d-aspartate receptor subtypes to zinc inhibition. Mol Pharmacol. 1997;51:1015–1023
  5. Choi Y-B, Lipton SA. Identification and mechanism of action of two histidine residues underlying the high-affinity Zn2+ inhibition of the NMDA receptor. Neuron. 1999;23:171–180
  6. Chu B, Anantharam V, Treistman SN. Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem. 1995;65:140–148
  7. Cik M, Chazot PL, Stephenson FA. Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: a biochemical characterization. Biochem J. 1993;296(Pt 3):877–883
  8. Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev. 1999;51:7–61
  9. Fayyazuddin A, Villarroel A, Le Goff A, Lerma J, Neyton J. Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors. Neuron. 2000;25:683–694
  10. Kuner T, Schoepfer R, Korpi ER. Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. Neuroreport. 1993;5:297–300
  11. Lovinger DM. Developmental decrease in ethanol inhibition of N-methyl-d-aspartate receptors in rat neocortical neurons: relation to the actions of ifenprodil. J Pharmacol Exp Ther. 1995;274:164–172
  12. Lovinger DM. Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn Schmiedebergs Arch Pharmacol. 1997;356:267–282
  13. Masood K, Wu C, Brauneis U, Weight FF. Differential ethanol sensitivity of recombinant N-methyl-d-aspartate receptor subunits. Mol Pharmacol. 1994;45:324–329
  14. Mirshahi T, Woodward JJ. Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg2+-insensitive mutants. Neuropharmacology. 1995;34:347–355
  15. Paoletti P, Ascher P, Neyton J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci. 1997;17:5711–5725
  16. Traynelis SF, Burgess MF, Zheng F, Lyuboslavsky P, Powers JL. Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. J Neurosci. 1998;18:6163–6175
  17. Williams K. Separating dual effects of zinc at recombinant N-methyl-d-aspartate receptors. Neurosci Lett. 1996;215:9–12
  18. Woodward JJ. Ethanol and NMDA receptor signaling. Crit Rev Neurobiol. 2000;14:69–89
  19. Zheng F, Gingrich MB, Traynelis SF, Conn PJ. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci. 1998;1:185–191

PII: S0741-8329(03)00189-7

doi: 10.1016/j.alcohol.2003.07.002

Alcohol
Volume 31, Issue 1 , Pages 71-76 , August 2003

Article Tools

* Image Usage & Resolution