Alcohol
Volume 31, Issue 3 , Pages 137-147 , November 2003

Immune response modulation in acutely ethanol-intoxicated, acutely diabetic male and female rats

  • Joseph O Olubadewo

      Affiliations

    • College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-504-520-7435; fax: +1-504-520-7930.
    • ,
  • Judy A Spitzer

      Affiliations

    • Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA

Received 11 July 2003 ,Revised 29 September 2003 ,Accepted 30 September 2003.

References 

  1. Avogaro A, Fontana P, Valerio A, Trevisan R, Riccio A, Del Prato S, et al. Alcohol impairs insulin sensitivity in normal subjects. Diabetes Res. 1987;5:23–27
  2. Bagdade JD, Root RK, Bulgar RJ. Impaired leukocytic function in patients with poorly controlled diabetes. Diabetes. 1974;23:9–15
  3. Basista MH, Gavaler J, Stieffenhofer A, Love K, Rosenblum E, Dindzans VJ. Effect of ethanol on Kupffer cell function. Alcohol Clin Exp Res. 1993;17:556–560
  4. Bautista AP, Elliot KE. Acute ethanol intoxication regulates f-met-leu-phe-induced chemotaxis and superoxide release by neutrophils and Kupffer cells through modulation of the formyl peptide receptor in the rat. Life Sci. 1994;54:721–730
  5. Briscoe HF, Allison F. Diabetes and host resistance (I. Effect of alloxan diabetes upon the phagocytic and bactericidal efficiency of rat leukocytes for Pneumococcus). J Bacteriol. 1965;90:1537–1541
  6. Bukara M, Bautista AP. Acute alcohol intoxication and gadolinium chloride attenuate endotoxin-induced release of CC chemokines in the rat. Alcohol. 2000;20:193–203
  7. Cruickshank AJ. Resistance to infection in the alloxan diabetic rabbit. J Pathol Bacteriol. 1954;67:323–334
  8. Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol. 1999;26:259–265
  9. Institute of Laboratory Animal Resources , Commission on Life Sciences , National Research Council . Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996;
  10. Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP. Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity. 1999;31:1–14
  11. Kato S, Kurose I, Higuchi H, Ebinuma H, Saito H, Miura S, et al. Effect of chronic ethanol feeding on Kupffer cell–mediated antitumor cell activity. Alcohol Clin Exp Res. 1996;20(1 Suppl):66A–68A
  12. Koo DJ, Chaudry IH, Wang P. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J Surg Res. 1999;83:151–157
  13. Kukreja A, Maclaren NK. Autoimmunity and diabetes. J Clin Endocrinol Metab. 1999;84:4371–4378
  14. Leksowski W, Kawalaski H, Czuba Z, Krol W, Gorczyca P, Dworniczak S, et al. Immunological parameters in patients suffering from alcohol-dependence syndrome. Immunopharmacology. 2000;46:65–70
  15. Liu BF, Miyata S, Kojima H, Uriuhara A, Kusunoki H, Suzuki K, et al. Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products. Diabetes. 1999;48:2074–2082
  16. Lohmann T, Laue S, Nietzschmann U, Kapellen TM, Lehmann I, Schroeder S, et al. Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Diabetes. 2002;51:2474–2480
  17. Nakano K, Yoshida T, Kondo M, Muramatsu S. Immune responsiveness and phagocytic activity of macrophages in streptozotocin (SZ)-induced diabetic mice. Endocrinol Jpn. 1984;31:15–22
  18. O'Farrelly C, Crispe IN. Prometheus through the looking glass: reflections on the hepatic immune system. Immunol Today. 1999;20:394–398
  19. Okuda K, Tadokoro I, Noguchi Y. Nitroblue tetrazolium (NBT)-dye test and the myeloperoxidase reaction of human leukocytes. Jpn J Microbiol. 1974;18:337–342
  20. Okuda K, Tadokoro I, Noguchi Y. Intraleukocytic bactericidal activity in patients receiving corticosteroid and radiation therapy, and in patients with diabetes mellitus. Jpn J Microbiol. 1975;19:97–103
  21. Orie NN, Aloamaka CP. Duration-dependent variability in the responses of diabetic rat aorta to noradrenaline and 5-hydroxytryptamine. Gen Pharmacol. 1993;24:243–246
  22. Palmer DL. Host defense impairment in the alcoholic. Immunocompromised Host. 1989;6:2–15
  23. Phillips GB, Safrit HF. Alcoholic diabetes. Induction of glucose intolerance with alcohol. JAMA. 1971;217:1513–1519
  24. Richardson R. Immunity in diabetes (IV. Measurements of phagocytic activity in diabetes mellitus). Am J Med Sci. 1942;204:29–36
  25. Saiki O, Negoro S, Tsuyuguchi I, Yamamura Y. Depressed immunological defense mechanisms in mice with experimentally induced diabetes. Infect Immun. 1980;28:127–131
  26. Shiratori Y, Teraoka H, Matano S, Matsumoto K, Kamii K, Tanaka M. Kupffer cell function in chronic ethanol-fed rats. Liver. 1989;9:351–359
  27. Spangler JG, Konen JC, McGann KP. Prevalence and predictors of problem drinking among primary care diabetic patients. J Fam Pract. 1993;37:370–375
  28. Spitzer JA, Spitzer JJ. Lipopolysaccharide tolerance and ethanol modulate hepatic nitric oxide production in a gender-dependent manner. Alcohol. 2000;21:27–35
  29. Spitzer JA, Zhang P. Hepatic cellular interactions in endotoxaemia and sepsis. Biochem Soc Trans. 1995;23:993–998
  30. Spitzer JA, Zhang P. Gender difference in phagocytic responses in the blood and liver, and the generation of cytokine induced neutrophil chemoattractant in the liver of acutely ethanol-intoxicated rats. Alcohol Clin Exp Res. 1996;20:914–920
  31. Spitzer JA, Zhang P. Gender differences in neutrophil function and cytokine induced neutrophil chemoattractant generation in endotoxic rats. Inflammation. 1996;20:485–498
  32. Spitzer JA, Zhang P, Bagby GJ, Stouwe CV, Nelson S. Sex differences in the modulation by ethanol of lung chemotaxis. Alcohol. 2002;28:95–102
  33. Spitzer JJ, Bautista A. Alcohol, cytokines and immunodeficiency. In:  Friedman H,  Klein TW,  Spector S editor. Drugs of Abuse, Immunity and AIDS. vol. 335:New York: Plenum Press; 1993;p. 159–164
  34. Szabo G. Consequences of alcohol consumption on host defense. Alcohol Alcohol. 1999;34:830–841
  35. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Connor HD, Adachi Y, et al. Role of Kupffer cells, endotoxin and free radicals in hepatotoxicity due to prolonged alcohol consumption: studies in female and male rats. J Nutr. 1997;127(5 Suppl):903S–906S
  36. Ulich TR, Howard SC, Remick DG, Wittwer A, Yi ES, Yin S, et al. Intratracheal administration of endotoxin and cytokines (VI. Antiserum to CINC inhibits acute inflammation). Am J Physiol. 1995;268(2 Pt 1):L245–L250
  37. Wittwer AJ, Carr LS, Zagorski J, Dolecki GJ, Crippes BA, De Larco JE. High-level expression of cytokine-induced neutrophil chemoattractant (CINC) by a metastatic rat cell line: purification and production of blocking antibodies. J Cell Physiol. 1993;156:421–427
  38. Yokoyama A, Matsushita S, Ishii H, Tagaki T, Maruyama K, Tsuchiya M. The impact of diabetes mellitus on the prognosis of alcoholics. Alcohol Alcohol. 1994;29:181–186
  39. Zhang P, Xie M, Spitzer JA. Hepatic neutrophil sequestration in early sepsis: enhanced expression of adhesion molecules and phagocytic activity. Shock. 1994;2:133–140
  40. Zhang P, Xie M, Zagorski J, Spitzer JA. Attenuation of hepatic neutrophil sequestration by anti-CINC antibody in endotoxic rats. Shock. 1995;4:262–268

PII: S0741-8329(03)00218-0

doi: 10.1016/j.alcohol.2003.09.004

Alcohol
Volume 31, Issue 3 , Pages 137-147 , November 2003

Article Tools

* Image Usage & Resolution